{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:10:45Z","timestamp":1773403845492,"version":"3.50.1"},"reference-count":25,"publisher":"International College of Surgeons","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Hematogenous metastasis of esophageal adenocarcinoma to the skeletal muscle is uncommon. We report a rare case of esophageal adenocarcinoma with metastasis to the skeletal muscle. During pretherapeutic examination, a painful mass was detected in the left thigh of a 49-year-old man. Endoscopic biopsy identified poorly differentiated, advanced esophageal adenocarcinoma. Computed tomography (CT) revealed wall thickening in the distal esophagus. Two enlarged lymph nodes were detected\u2014the middle thoracic paraesophageal lymph node in the mediastinum and the right cardiac lymph node. <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) positron emission tomography demonstrated left thigh metastasis, which had not been detected by CT 3 weeks previously, with increased accumulation of FDG. Therefore, ultrasound-guided core-needle biopsy was performed. Histologic and immunohistochemical findings supported a diagnosis of poorly differentiated adenocarcinoma. The final diagnosis was primary esophageal adenocarcinoma with distant metastasis to the skeletal (left thigh) muscle. The rate of disease progression in this case emphasizes the malignant potential of esophageal adenocarcinoma. A few cases of skeletal metastasis from advanced esophageal adenocarcinoma have been previously reported. However, rapid metastasis to a distant skeletal muscle with no other hematogenous metastasis is quite rare. Early detection and rapid treatment are especially important in cases of esophageal adenocarcinoma.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00166.1","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T16:00:08Z","timestamp":1418054408000},"page":"650-655","source":"Crossref","is-referenced-by-count":10,"title":["Primary Esophageal Adenocarcinoma With Distant Metastasis to the Skeletal Muscle"],"prefix":"10.9738","volume":"99","author":[{"given":"Makoto","family":"Sohda","sequence":"first","affiliation":[{"name":"Gunma General Prefectural Cancer Center, Ohta, Japan"},{"name":"Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ojima","sequence":"additional","affiliation":[{"name":"Gunma General Prefectural Cancer Center, Ohta, Japan"},{"name":"Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Sano","sequence":"additional","affiliation":[{"name":"Gunma General Prefectural Cancer Center, Ohta, Japan"},{"name":"Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Fukai","sequence":"additional","affiliation":[{"name":"Gunma General Prefectural Cancer Center, Ohta, Japan"},{"name":"Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"8","key":"i0020-8868-99-5-650-b01","series-title":"Cancer","first-page":"1820","article-title":"National Cancer Data Base report on esophageal carcinoma","volume":"78","author":"Daly\n              JM,","year":"1996","unstructured":"Daly\n              JM, \n            \n              Karnell\n              LH, \n            \n              Menck\n              HR. \n          \n          National Cancer Data Base report on esophageal carcinoma. Cancer1996;78(8):1820\u20131828"},{"issue":"9","key":"i0020-8868-99-5-650-b02","series-title":"Ann Oncol","first-page":"951","article-title":"Oesophageal cancer treatment: studies, strategies and facts","volume":"9","author":"Wobst\n              A,","year":"1998","unstructured":"Wobst\n              A, \n            \n              Audisio\n              RA, \n            \n              Colleoni\n              M, \n            \n              Geraghty\n              JG. \n          \n          Oesophageal cancer treatment: studies, strategies and facts. 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J Craniofac Surg2011;22(2):736\u2013737"},{"issue":"12","key":"i0020-8868-99-5-650-b04","series-title":"Clin Nucl Med","first-page":"810","article-title":"Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging","volume":"31","author":"Heffernan\n              E,","year":"2006","unstructured":"Heffernan\n              E, \n            \n              Fennelly\n              D, \n            \n              Collins\n              CD. \n          \n          Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging. Clin Nucl Med2006;31(12):810\u2013811"},{"issue":"5","key":"i0020-8868-99-5-650-b05","series-title":"Clin Nucl Med","first-page":"335","article-title":"PET detection of solitary distant skeletal muscle metastasis of esophageal adenocarcinoma","volume":"30","author":"Wu\n              G,","year":"2005","unstructured":"Wu\n              G, \n            \n              Bybel\n              B, \n            \n              Brunken\n              R, \n            \n              Lin\n              H, \n            \n              Neumann\n              D. \n          \n          PET detection of solitary distant skeletal muscle metastasis of esophageal adenocarcinoma. Clin Nucl Med2005;30(5):335\u2013337"},{"issue":"9","key":"i0020-8868-99-5-650-b06","series-title":"South Med J","first-page":"1076","article-title":"Metastatic gastroesophageal adenocarcinoma to skeletal muscle: a unique event","volume":"95","author":"Rehman\n              SU,","year":"2002","unstructured":"Rehman\n              SU, \n            \n              Cope\n              DW, \n            \n              Basile\n              JN. \n          \n          Metastatic gastroesophageal adenocarcinoma to skeletal muscle: a unique event. South Med J2002;95(9):1076\u20131078"},{"issue":"3","key":"i0020-8868-99-5-650-b07","series-title":"J Gastrointestin Liver Dis","first-page":"371","article-title":"An unusual presentation of metastatic esophageal adenocarcinoma presenting as thigh pain","volume":"18","author":"Norris\n              WE,","year":"2009","unstructured":"Norris\n              WE, \n            \n              Perry\n              JL, \n            \n              Moawad\n              FJ, \n            \n              Horwhat\n              JD. \n          \n          An unusual presentation of metastatic esophageal adenocarcinoma presenting as thigh pain. J Gastrointestin Liver Dis2009;18(3):371\u2013374"},{"issue":"8","key":"i0020-8868-99-5-650-b08","series-title":"Scand J Gastroenterol","first-page":"1000","article-title":"Metastasis to skeletal muscle from esophageal adenocarcinoma","volume":"40","author":"Heyer\n              CM,","year":"2005","unstructured":"Heyer\n              CM, \n            \n              Rduch\n              GJ, \n            \n              Zgoura\n              P, \n            \n              Stachetzki\n              U, \n            \n              Voigt\n              E, \n            \n              Nicolas\n              V. \n          \n          Metastasis to skeletal muscle from esophageal adenocarcinoma. Scand J Gastroenterol2005;40(8):1000\u20131004"},{"issue":"5","key":"i0020-8868-99-5-650-b09","series-title":"Am J Epidemiol","first-page":"582","article-title":"Australian Cancer Study. 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Gut2008;57(2):173\u2013180"},{"issue":"8","key":"i0020-8868-99-5-650-b11","series-title":"JAMA","first-page":"961","article-title":"Utility of endoscopic screening for upper gastrointestinal adenocarcinoma","volume":"284","author":"Lagergren\n              J,","year":"2000","unstructured":"Lagergren\n              J, \n            \n              Ye\n              W, \n            \n              Bergstr\u00f6m\n              R, \n            \n              Nyr\u00e9n\n              O. \n          \n          Utility of endoscopic screening for upper gastrointestinal adenocarcinoma. JAMA2000;284(8):961\u2013962"},{"issue":"1","key":"i0020-8868-99-5-650-b12","series-title":"Gastroenterology","first-page":"73","article-title":"Australian Cancer Study. 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Helicobacter pylori infection and the risks of Barrett's oesophagus: a population-based case-control study","volume":"130","author":"Thrift\n              AP,","year":"2012","unstructured":"Thrift\n              AP, \n            \n              Pandeya\n              N, \n            \n              Smith\n              KJ, \n            \n              Green\n              AC, \n            \n              Hayward\n              NK, \n            \n              Webb\n              PM\n            \n          \n          et al. Helicobacter pylori infection and the risks of Barrett's oesophagus: a population-based case-control study. Int J Cancer2012;130(10):2407\u20132416"},{"key":"i0020-8868-99-5-650-b14","series-title":"Guidelines for the Clinical and Pathological Studies on Carcinoma of the Esophagus [in Japanese]. 10th ed","year":"2008","unstructured":"Japanese Society for Esophageal Disease. 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Clin Orthop Relat Res1998;(355):272\u2013281"},{"issue":"6","key":"i0020-8868-99-5-650-b16","series-title":"J Nucl Med","first-page":"980","article-title":"Detection of distant metastases in esophageal cancer with (18)F-FDG PET","volume":"45","author":"Heeren\n              PA,","year":"2004","unstructured":"Heeren\n              PA, \n            \n              Jager\n              PL, \n            \n              Bongaerts\n              F, \n            \n              van Dullemen\n              H, \n            \n              Sluiter\n              W, \n            \n              Plukker\n              JT. \n          \n          Detection of distant metastases in esophageal cancer with (18)F-FDG PET. J Nucl Med2004;45(6):980\u2013987"},{"issue":"6","key":"i0020-8868-99-5-650-b17","series-title":"Onkologie","first-page":"282","article-title":"Skeletal muscle metastases from pancreatic cancer","volume":"11","author":"Larson\n              DA,","year":"1988","unstructured":"Larson\n              DA, \n            \n              Bottles\n              K, \n            \n              Federle\n              M, \n            \n              Fippin\n              L, \n            \n              Luce\n              J. \n          \n          Skeletal muscle metastases from pancreatic cancer. Onkologie1988;11(6):282\u2013285"},{"issue":"729","key":"i0020-8868-99-5-650-b18","series-title":"Br J Radiol","first-page":"849","article-title":"Metastatic adenocarcinoma of the paraspinal muscles","volume":"61","author":"O'Keeffe\n              D,","year":"1988","unstructured":"O'Keeffe\n              D, \n            \n              Gholkar\n              A. \n          \n          Metastatic adenocarcinoma of the paraspinal muscles. Br J Radiol1988;61(729):849\u2013851"},{"issue":"1","key":"i0020-8868-99-5-650-b19","series-title":"Am J Gastroenterol","first-page":"76","article-title":"Gastric adenocarcinoma presenting with soft tissue masses","volume":"8","author":"Porile\n              JL,","year":"1990","unstructured":"Porile\n              JL, \n            \n              Olopade\n              OI, \n            \n              Hoffman\n              PC. \n          \n          Gastric adenocarcinoma presenting with soft tissue masses. 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Dis Colon Rectum1987;30(10):805\u2013808"},{"issue":"8","key":"i0020-8868-99-5-650-b21","series-title":"Cancer","first-page":"1530","article-title":"Skeletal muscle metastases from lung cancer","volume":"5","author":"Sridhar\n              KS,","year":"1987","unstructured":"Sridhar\n              KS, \n            \n              Rao\n              RK, \n            \n              Kunhardt\n              B. \n          \n          Skeletal muscle metastases from lung cancer. Cancer1987;59(8):1530\u20131534"},{"issue":"4","key":"i0020-8868-99-5-650-b22","series-title":"Jpn J Clin Oncol","first-page":"210","article-title":"Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases","volume":"34","author":"Tuoheti\n              Y,","year":"2004","unstructured":"Tuoheti\n              Y, \n            \n              Okada\n              K, \n            \n              Osanai\n              T, \n            \n              Nishida\n              J, \n            \n              Ehara\n              S, \n            \n              Hashimoto\n              M\n            \n            et al\n          . Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol2004;34(4):210\u2013214"},{"issue":"11","key":"i0020-8868-99-5-650-b23","series-title":"Clin Radiol","first-page":"883","article-title":"Skeletal muscle metastasis from transitional cell carcinoma of the urinary bladder: clinicoradiological features","volume":"58","author":"Nabi\n              G,","year":"2003","unstructured":"Nabi\n              G, \n            \n              Gupta\n              NP, \n            \n              Gandhi\n              D. \n          \n          Skeletal muscle metastasis from transitional cell carcinoma of the urinary bladder: clinicoradiological features. 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