{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:04Z","timestamp":1751485204904,"version":"3.41.0"},"reference-count":9,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>A 53-year-old man with multiple liver metastasis of esophageal cancer underwent four courses of chemotherapy. After four courses of chemotherapy, positron emission tomography showed progressive disease. Because it was difficult to control the cancer only by chemotherapy, we performed proton beam therapy (PBT) combined with chemotherapy. The irradiated parts were the primary tumor, liver metastases (S2\/S4\/S6), and mediastinal lymph nodes. The primary tumor including the mediastinal lymph nodes and the S2\/S4\/S6 metastases received proton beam irradiation at a total dose of 68.2 Gy in 31 fractions and 66.0 Gy in 30 fractions, respectively, according to tumor location. This resulted in a complete response as shown by positron emission tomography. In our experience, PBT exerted a curative effect on liver metastases of esophageal cancer. It is thought that PBT may be effective in the treatment of esophageal cancer. This is the first report about PBT for liver metastases of esophageal cancer.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00188.1","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T19:06:34Z","timestamp":1421435194000},"page":"180-184","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of Proton Beam Therapy on Liver Metastases of Esophageal Cancer: Report of a Case"],"prefix":"10.9738","volume":"100","author":[{"given":"Hiroto","family":"Muroi","sequence":"first","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Domeki","sequence":"additional","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Murakami","sequence":"additional","affiliation":[{"name":"Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Southern Tohoku Proton Therapy Center, Koriyama, Fukushima, 963-8563, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Takada","sequence":"additional","affiliation":[{"name":"Southern Tohoku Proton Therapy Center, Koriyama, Fukushima, 963-8563, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"3","key":"i0020-8868-100-1-180-b01","series-title":"Int J Radiat Oncol Biol Phys","first-page":"805","article-title":"Proton beam therapy for aged patients with hepatocellular carcinoma","volume":"69","author":"Hata\n              M,","year":"2007","unstructured":"Hata\n              M, \n            \n              Tokuuye\n              K, \n            \n              Sugahara\n              S, \n            \n              Tohno\n              E, \n            \n              Nakayama\n              H, \n            \n              Fukumitsu\n              N\n            \n            et al\n          . Proton beam therapy for aged patients with hepatocellular carcinoma. Int J Radiat Oncol Biol Phys2007;69(3):805\u2013812"},{"issue":"50","key":"i0020-8868-100-1-180-b02","series-title":"Hepatogastroenterology","first-page":"532","article-title":"Conformal radiation therapy for liver metastasis of esophageal carcinoma","volume":"50","author":"Ikeda\n              Y,","year":"2003","unstructured":"Ikeda\n              Y, \n            \n              Niimi\n              M, \n            \n              Kan\n              S, \n            \n              Shatari\n              T, \n            \n              Takami\n              H, \n            \n              Kodaira\n              S\n            \n            et al\n          . Conformal radiation therapy for liver metastasis of esophageal carcinoma. Hepatogastroenterology2003;50(50):532\u2013534"},{"issue":"10","key":"i0020-8868-100-1-180-b03","series-title":"Clin Cancer Res","first-page":"3799","article-title":"Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162patients","volume":"11","author":"Chiba\n              T,","year":"2005","unstructured":"Chiba\n              T, \n            \n              Tokuuye\n              K, \n            \n              Matsuzaki\n              Y, \n            \n              Sugahara\n              S, \n            \n              Chuganji\n              Y, \n            \n              Kagei\n              K\n            \n            et al\n          . Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162patients. 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Cancer2011;117(13):3053\u20133059"},{"issue":"3","key":"i0020-8868-100-1-180-b05","series-title":"Int J Radiat Oncol Biol Phys","first-page":"e529","article-title":"Evaluation of liver function after proton beam therapy for hepatocellular carcinoma","volume":"82","author":"Mizumoto\n              M,","year":"2012","unstructured":"Mizumoto\n              M, \n            \n              Okumura\n              T, \n            \n              Hashimoto\n              T, \n            \n              Fukuda\n              K, \n            \n              Oshiro\n              Y, \n            \n              Fukumitsu\n              N\n            \n            et al\n          . Evaluation of liver function after proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys2012;82(3):e529\u2013e535"},{"issue":"9","key":"i0020-8868-100-1-180-b06","series-title":"J Clin Oncol","first-page":"1839","article-title":"PhaseIIstudy of radiotherapy employing proton beam for hepatocellular carcinoma","volume":"23","author":"Kawashima\n              M,","year":"2005","unstructured":"Kawashima\n              M, \n            \n              Furuse\n              J, \n            \n              Nishio\n              T, \n            \n              Konishi\n              M, \n            \n              Ishii\n              H, \n            \n              Kinoshita\n              T\n            \n            et al\n          . PhaseIIstudy of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol2005;23(9):1839\u20131846"},{"issue":"2","key":"i0020-8868-100-1-180-b07","series-title":"CA Cancer J Clin","first-page":"74","article-title":"Global cancer statistics 2002","volume":"55","author":"Parkin\n              DM,","year":"2005","unstructured":"Parkin\n              DM, \n            \n              Bray\n              F, \n            \n              Ferlay\n              J, \n            \n              Pisani\n              P. \n          \n          Global cancer statistics 2002. CA Cancer J Clin2005;55(2):74\u2013108"},{"issue":"12","key":"i0020-8868-100-1-180-b08","series-title":"Strahlenther Onkol","first-page":"713","article-title":"Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis","volume":"182","author":"Hata\n              M,","year":"2006","unstructured":"Hata\n              M, \n            \n              Tokuuye\n              K, \n            \n              Sugahara\n              S, \n            \n              Fukumitsu\n              N, \n            \n              Hashimoto\n              T, \n            \n              Ohnishi\n              K\n            \n            et al\n          . Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis. Strahlenther Onkol2006;182(12):713\u2013720"},{"issue":"2","key":"i0020-8868-100-1-180-b09","series-title":"J Thorac Oncol","first-page":"370","article-title":"Results of proton beam therapy without concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer","volume":"7","author":"Oshiro\n              Y,","year":"2012","unstructured":"Oshiro\n              Y, \n            \n              Mizumoto\n              M, \n            \n              Okumura\n              T, \n            \n              Hashimoto\n              T, \n            \n              Fukumitsu\n              N, \n            \n              Ohkawa\n              A\n            \n            et al\n          . Results of proton beam therapy without concurrent chemotherapy for patients with unresectable stage III non-small cell lung cancer. J Thorac Oncol2012;7(2):370\u2013375"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/100\/1\/article-p180.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/100\/1\/180\/2216239\/intsurg-d-13-00188_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/100\/1\/article-p180.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/100\/1\/article-p180.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:10:06Z","timestamp":1751483406000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/100\/1\/article-p180.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":9,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-13-00188.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}