{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:18:06Z","timestamp":1751516286305,"version":"3.41.0"},"reference-count":23,"publisher":"International College of Surgeons","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>To clarify the physiologic function of the enteric nervous system (ENS) in the elongated sigmoid colon (ESC) of patients with sigmoid volvulus (SV), we examined the enteric nerve responses in lesional and normal longitudinal muscle strips (LMS) derived from patients with ESC and patients who underwent colon resection for colonic cancers. Thirty preparations of LMS were taken from the lesional sigmoid colons of 10 ESC patients with SV (8 men and 2 women, aged 53 to 80 years, mean 66.2 years). Forty preparations of LMS were taken from the normal sigmoid colons (NSC) of 20 patients with colonic cancer (12 men and 8 women, aged 55 to 76 years, mean 62.3 years). A mechanographic technique was used to evaluate in vitro muscle responses to electrical field stimulation (EFS) before and after treatment with various autonomic nerve blockers. Response to EFS before blockade of the adrenergic and cholinergic nerves was as follows: NSC and ESC significantly demonstrated relaxation reaction rather than contraction reaction (<jats:italic>P<\/jats:italic> = 0.0253, <jats:italic>P<\/jats:italic> &lt; 0.0001, respectively). ESC showed relaxation reaction more than NSC (<jats:italic>P<\/jats:italic> = 0.1138). Response to EFS after blockade of the adrenergic and cholinergic nerves was as follows: NSC and ESC significantly demonstrated relaxation reaction via nonadrenergic noncholinergic (NANC) inhibitory nerves rather than contraction reaction via NANC excitatory nerves (<jats:italic>P<\/jats:italic> &lt; 0.0001, <jats:italic>P<\/jats:italic> &lt; 0.0001, respectively). ESC with SV significantly showed relaxation reaction more than NSC (<jats:italic>P<\/jats:italic> = 0.0092). An increased response of relaxation mediated NANC inhibitory nerves may play a role in impaired motility in the ESC of patients with SV.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00198.1","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:06:49Z","timestamp":1417478809000},"page":"699-704","source":"Crossref","is-referenced-by-count":0,"title":["Role of the Enteric Nervous System in the Elongated Sigmoid Colon of Patients With Sigmoid Volvulus"],"prefix":"10.9738","volume":"99","author":[{"given":"Ryouichi","family":"Tomita","sequence":"first","affiliation":[{"name":"Department of Surgery, Nippon Dental University Hospital at Tokyo, Japan"},{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiminobu","family":"Sugitou","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugumichi","family":"Koshinaga","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-99-6-699-b01","series-title":"Int Surg","first-page":"107","article-title":"Acute volvulus of the megasigmoid and its treatment","volume":"54","author":"Friedlaender\n              E.","year":"1970","unstructured":"Friedlaender\n              E. \n          \n          Acute volvulus of the megasigmoid and its treatment. Int Surg1970;54(2):107\u2013111"},{"issue":"1","key":"i0020-8868-99-6-699-b02","series-title":"Int Surg","first-page":"46","article-title":"Mini-invasive surgery for sigmoid volvulus","volume":"84","author":"Sarli\n              L,","year":"1999","unstructured":"Sarli\n              L, \n            \n              Pietra\n              N, \n            \n              Costi\n              R. \n          \n          Mini-invasive surgery for sigmoid volvulus. Int Surg1999;84(1):46\u201348"},{"issue":"11","key":"i0020-8868-99-6-699-b03","series-title":"Am J Gastroenterol","first-page":"3362","article-title":"Colonic spasm and pseudo-obstruction in an elongated colon secondary to physical exertion: diagnosis by stress barium enema","volume":"94","author":"McMahon\n              JM,","year":"1999","unstructured":"McMahon\n              JM, \n            \n              Underwood\n              ES, \n            \n              Kirby\n              WE. \n          \n          Colonic spasm and pseudo-obstruction in an elongated colon secondary to physical exertion: diagnosis by stress barium enema. Am J Gastroenterol1999;94(11):3362\u20133364"},{"issue":"3","key":"i0020-8868-99-6-699-b04","series-title":"Am Surg","first-page":"271","article-title":"The twisted colon: a review of sigmoid volvulus","volume":"78","author":"Osiro\n              SB,","year":"2012","unstructured":"Osiro\n              SB, \n            \n              Cunningham\n              D, \n            \n              Shoja\n              MM, \n            \n              Tubbs\n              RS, \n            \n              Gielecki\n              J, \n            \n              Loukas\n              M. \n          \n          The twisted colon: a review of sigmoid volvulus. Am Surg2012;78(3):271\u2013278"},{"issue":"5","key":"i0020-8868-99-6-699-b05","series-title":"Gastroenterology","first-page":"1459","article-title":"Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon","volume":"123","author":"Wedel\n              T,","year":"2002","unstructured":"Wedel\n              T, \n            \n              Spiegler\n              J, \n            \n              Soellner\n              S, \n            \n              Roblick\n              UJ, \n            \n              Schiedeck\n              THK, \n            \n              Bruch\n              HP\n            \n            et al\n          . Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. Gastroenterology2002;123(5):1459\u20131467"},{"issue":"3","key":"i0020-8868-99-6-699-b06","series-title":"Am J Surg Pathol","first-page":"460","article-title":"The enteric nervous system in chagasic and idiopathic megacolon","volume":"31","author":"Iantorno\n              G,","year":"2007","unstructured":"Iantorno\n              G, \n            \n              Bassotti\n              G, \n            \n              Kogan\n              Z, \n            \n              Lumi\n              CM, \n            \n              Cabanne\n              AM, \n            \n              Fisogni\n              S\n            \n            et al\n          . The enteric nervous system in chagasic and idiopathic megacolon. Am J Surg Pathol2007;31(3):460\u2013468"},{"issue":"1","key":"i0020-8868-99-6-699-b07","series-title":"J Pediatr Gastroenterol Nutr","first-page":"22","article-title":"Van den Berg MM, Lorenzo CD, Mousa HM, Benninga MA, Boeckxstaens GEE, Luquette M. Morphological changes of enteric nervous system, interstitial cells of Cajal, and smooth muscle in children with colonic motility disorders","volume":"48","year":"2008","unstructured":"Van den Berg MM, Lorenzo CD, Mousa HM, Benninga MA, Boeckxstaens GEE, Luquette M. Morphological changes of enteric nervous system, interstitial cells of Cajal, and smooth muscle in children with colonic motility disorders. J Pediatr Gastroenterol Nutr2008;48(1):22\u201329"},{"issue":"7","key":"i0020-8868-99-6-699-b08","series-title":"J Pediatr Surg","first-page":"14","article-title":"How common is colonic elongation in children with slow-transit constipation or anorectal retention?","volume":"47","author":"Yik\n              YI,","year":"2012","unstructured":"Yik\n              YI, \n            \n              Cook\n              DJ, \n            \n              Veysey\n              DM, \n            \n              Tudball\n              CF, \n            \n              Cain\n              TM, \n            \n              Southwell\n              BR\n            \n            et al\n          . How common is colonic elongation in children with slow-transit constipation or anorectal retention?J Pediatr Surg2012;47(7):14\u201320"},{"issue":"12","key":"i0020-8868-99-6-699-b09","series-title":"Surg Today","first-page":"1115","article-title":"Surgical treatment of a sigmoid voluvulus associated with megacolon: Report of a case","volume":"30","author":"Kudaka\n              M,","year":"2000","unstructured":"Kudaka\n              M, \n            \n              Kudaka\n              H, \n            \n              Tomiyama\n              T, \n            \n              Yogi\n              M, \n            \n              Inafuku\n              Y, \n            \n              Kawano\n              K\n            \n            et al\n          . Surgical treatment of a sigmoid voluvulus associated with megacolon: Report of a case. Surg Today2000;30(12):1115\u20131117"},{"issue":"1","key":"i0020-8868-99-6-699-b10","series-title":"World J Surg","first-page":"88","article-title":"Role of ganglion cells in sigmoid volvulus","volume":"29","author":"Furuya\n              Y,","year":"2005","unstructured":"Furuya\n              Y, \n            \n              Yasuhara\n              H, \n            \n              Yanagie\n              H, \n            \n              Naka\n              S, \n            \n              Takenoue\n              T, \n            \n              Shinkawa\n              H\n            \n            et al\n          . Role of ganglion cells in sigmoid volvulus. World J Surg2005;29(1):88\u201391"},{"issue":"867","key":"i0020-8868-99-6-699-b11","series-title":"Philos Trans R Soc Lond B Biol Sci","first-page":"123","article-title":"The nervous release and action of substances which affect intestinal through neither adrenoreceptors nor cholinoreceptors","volume":"265","author":"Furness\n              JB,","year":"1973","unstructured":"Furness\n              JB, \n            \n              Costa\n              M. \n          \n          The nervous release and action of substances which affect intestinal through neither adrenoreceptors nor cholinoreceptors. Philos Trans R Soc Lond B Biol Sci1973;265(867):123\u2013133"},{"issue":"12","key":"i0020-8868-99-6-699-b12","series-title":"Dig Dis Sci","first-page":"2719","article-title":"Cholinergic stimulation and nonadrenergic, noncholinergic relaxation of human colonic circular muscle in idiopathic chronic constipation","volume":"43","author":"Mitolo-Chieppa\n              D,","year":"1998","unstructured":"Mitolo-Chieppa\n              D, \n            \n              Mansi\n              G, \n            \n              Rinaldi\n              R, \n            \n              Montagnani\n              M, \n            \n              Potenza\n              MA, \n            \n              Genualdo\n              M\n            \n            et al\n          . Cholinergic stimulation and nonadrenergic, noncholinergic relaxation of human colonic circular muscle in idiopathic chronic constipation. Dig Dis Sci1998;43(12):2719\u20132726"},{"issue":"7","key":"i0020-8868-99-6-699-b13","series-title":"Neurogastroenterol Motil","first-page":"685","article-title":"A comparison of the organization of longitudinal and circular contractions during pendular and segmental activity in the duodenum of the rat and guinea pig","volume":"24","author":"Lentle\n              RG,","year":"2012","unstructured":"Lentle\n              RG, \n            \n              Loubent\n              C, \n            \n              Hulls\n              C, \n            \n              Janssen\n              PW, \n            \n              Golding\n              MD, \n            \n              Chambers\n              J. \n          \n          A comparison of the organization of longitudinal and circular contractions during pendular and segmental activity in the duodenum of the rat and guinea pig. Neurogastroenterol Motil2012;24(7):685\u2013695"},{"issue":"35","key":"i0020-8868-99-6-699-b14","series-title":"Hepatogastroenterology","first-page":"1280","article-title":"Management of sigmoid colon volvulus","volume":"47","author":"Dulger\n              M,","year":"2000","unstructured":"Dulger\n              M, \n            \n              Canturk\n              NZ, \n            \n              Utkan\n              NZ, \n            \n              Gonullu\n              NN. \n          \n          Management of sigmoid colon volvulus. Hepatogastroenterology2000;47(35):1280\u20131283"},{"issue":"6","key":"i0020-8868-99-6-699-b15","series-title":"World J Gastroenterol","first-page":"921","article-title":"Clinical considerations and therapeutic strategy for sigmoid volvulus in the elderly: A study of 33 cases","volume":"13","author":"Safioleas\n              M,","year":"2007","unstructured":"Safioleas\n              M, \n            \n              Chatziconstantinou\n              C, \n            \n              Felekouras\n              E, \n            \n              Stamatakos\n              M, \n            \n              Papaconstantinou\n              I, \n            \n              Smirnis\n              A\n            \n            et al\n          . Clinical considerations and therapeutic strategy for sigmoid volvulus in the elderly: A study of 33 cases. World J Gastroenterol2007;13(6):921\u2013924"},{"issue":"2","key":"i0020-8868-99-6-699-b16","series-title":"J Surg Res","first-page":"385","article-title":"Loss of ganglion cells and marked attenuation of bowel wall in cecal dilatation","volume":"60","author":"Culloure\n              DW,","year":"1996","unstructured":"Culloure\n              DW, \n            \n              Hameer\n              HR. \n          \n          Loss of ganglion cells and marked attenuation of bowel wall in cecal dilatation. J Surg Res1996;60(2):385\u2013388"},{"issue":"1","key":"i0020-8868-99-6-699-b17","series-title":"Curr Opin Gastroenterol","first-page":"22","article-title":"Mediators and regulation of peristalsis","volume":"15","author":"Grider\n              JR,","year":"1999","unstructured":"Grider\n              JR, \n            \n              Foxx-Orenstein\n              AE. \n          \n          Mediators and regulation of peristalsis. Curr Opin Gastroenterol1999;15(1):22\u201325"},{"issue":"6","key":"i0020-8868-99-6-699-b18","series-title":"J Am Coll Surg","first-page":"717","article-title":"Sigmoid volvulus in children and adolescents","volume":"190","author":"Salas\n              S,","year":"2000","unstructured":"Salas\n              S, \n            \n              Angel\n              CA, \n            \n              Salas\n              N, \n            \n              Murillo\n              C, \n            \n              Swischuk\n              L. \n          \n          Sigmoid volvulus in children and adolescents. J Am Coll Surg2000;190(6):717\u2013716"},{"issue":"4","key":"i0020-8868-99-6-699-b19","series-title":"Can J Surg","first-page":"449","article-title":"Volvulus of the sigmoid, with special reference to the role of ganglion deficiency as an etiological factor","volume":"10","author":"Hildebrand\n              HD,","year":"1967","unstructured":"Hildebrand\n              HD, \n            \n              Wilson\n              JW. \n          \n          Volvulus of the sigmoid, with special reference to the role of ganglion deficiency as an etiological factor. Can J Surg1967;10(4):449\u2013454"},{"issue":"2","key":"i0020-8868-99-6-699-b20","series-title":"J Surg Res","first-page":"3385","article-title":"Loss of ganglion cell, marked attenuation of bowel wall in cecal dilatation","volume":"60","author":"Collure\n              DW,","year":"1996","unstructured":"Collure\n              DW, \n            \n              Hameer\n              HR. \n          \n          Loss of ganglion cell, marked attenuation of bowel wall in cecal dilatation. J Surg Res1996;60(2):3385\u2013388"},{"issue":"5","key":"i0020-8868-99-6-699-b21","series-title":"Dis Colon Rectum","first-page":"593","article-title":"Role of nitric oxide in the colon of patients with slow-transit constipation","volume":"45","author":"Tomita\n              R,","year":"2002","unstructured":"Tomita\n              R, \n            \n              Fujisaki\n              S, \n            \n              Ikeda\n              T, \n            \n              Fukuzawa\n              M. \n          \n          Role of nitric oxide in the colon of patients with slow-transit constipation. Dis Colon Rectum2002;45(5):593\u2013600"},{"issue":"1","key":"i0020-8868-99-6-699-b22","series-title":"Exp Physiol","first-page":"20","article-title":"Purinergic cotransmission","volume":"94","author":"Burnstook\n              G.","year":"2009","unstructured":"Burnstook\n              G. \n          \n          Purinergic cotransmission. Exp Physiol2009;94(1):20\u201324"},{"issue":"8","key":"i0020-8868-99-6-699-b23","series-title":"Neurogastroenterol Motil","first-page":"883","article-title":"Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation","volume":"22","author":"King\n              SK,","year":"2010","unstructured":"King\n              SK, \n            \n              Sutcliffe\n              JR, \n            \n              Ong\n              SY, \n            \n              Lee\n              M, \n            \n              Koh\n              TL, \n            \n              Wong\n              SQ\n            \n            et al\n          . Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation. 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