{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:18:47Z","timestamp":1773065927613,"version":"3.50.1"},"reference-count":15,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>We present a rare case of dedifferentiated liposarcoma confined to the spleen and splenic hilum. An 81-year-old man was referred to our hospital with a large asymptomatic splenic tumor. The patient underwent splenectomy, and the adipose tissue surrounding the splenic hilum was also resected. Microscopically, the tumor mainly consisted of high-grade spindle cells similar to those seen in undifferentiated pleomorphic liposarcoma. In the splenic hilum, scattered atypical cells were detected in the sclerosing component and adipose tissue. Immunohistochemically, both the spindle cells in the spleen and the atypical cells in the splenic hilum were positive for MDM2 and CDK4. The histopathologic diagnosis was dedifferentiated liposarcoma derived from an atypical lipomatous tumor\/well-differentiated liposarcoma of the adipose tissue in the splenic hilum with extension into the spleen. Dedifferentiated liposarcoma in the spleen and splenic hilum should be considered as a differential diagnosis of splenic tumors.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00203.1","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T19:06:34Z","timestamp":1421435194000},"page":"128-132","source":"Crossref","is-referenced-by-count":5,"title":["Dedifferentiated Liposarcoma Involving the Spleen and Splenic Hilum: A Report of a Case With a Rare Growth Pattern"],"prefix":"10.9738","volume":"100","author":[{"given":"Gen","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Minamiguchi","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ogiso","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tethushi","family":"Otani","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Ikai","sequence":"additional","affiliation":[{"name":"Division of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"2","key":"i0020-8868-100-1-128-b01","series-title":"West J Med","first-page":"88","article-title":"Splenomegaly in 2,505 patients at a large university medical center from 1913 to 1995. 1963 to 1995: 449 patients","volume":"169","author":"O'Reilly\n              RA.","year":"1998","unstructured":"O'Reilly\n              RA. \n          \n          Splenomegaly in 2,505 patients at a large university medical center from 1913 to 1995. 1963 to 1995: 449 patients. West J Med1998;169(2):88\u201397"},{"issue":"11","key":"i0020-8868-100-1-128-b02","series-title":"Cancer","first-page":"2001","article-title":"The spleen as a diagnostic specimen: a review of 10 years' experience at two tertiary care institutions","volume":"91","author":"Kraus\n              MD,","year":"2001","unstructured":"Kraus\n              MD, \n            \n              Fleming\n              MD, \n            \n              Vonderheide\n              RH. \n          \n          The spleen as a diagnostic specimen: a review of 10 years' experience at two tertiary care institutions. Cancer2001;91(11):2001\u20132009"},{"issue":"4","key":"i0020-8868-100-1-128-b03","series-title":"Radiographics","first-page":"1137","article-title":"From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation","volume":"24","author":"Abbott\n              RM,","year":"2004","unstructured":"Abbott\n              RM, \n            \n              Levy\n              AD, \n            \n              Aguilera\n              NS, \n            \n              Gorospe\n              L, \n            \n              Thompson\n              WM. \n          \n          From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. 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