{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:47:39Z","timestamp":1785498459287,"version":"3.56.0"},"reference-count":28,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Twenty percent of colon cancers present as an emergency. However, the association between emergency presentation and disease-free survival (DFS) remains uncertain. Consecutive patients who underwent elective (CC) and emergent (eCC) resection for colon cancer were included in the analysis. Survival outcomes were compared between the 2 groups in univariate\/multivariate analyses. A total of 439 patients underwent colonic resection for colon cancer during the interval 2000\u22122010; 97 (22.1%) presented as an emergency. eCC tumors were more often located at the splenic flexure (<jats:italic>P<\/jats:italic> = 0.017) and descending colon (<jats:italic>P<\/jats:italic> = 0.004). The eCC group displayed features of more advanced disease with a higher proportion of T4 (<jats:italic>P<\/jats:italic> = 0.009), N2 tumors (<jats:italic>P<\/jats:italic> &lt; 0.01) and lymphovascular invasion (<jats:italic>P<\/jats:italic>&lt; 0.01). eCC was associated with adverse locoregional recurrence (<jats:italic>P<\/jats:italic> = 0.02) and adverse DFS (<jats:italic>P<\/jats:italic> &lt; 0.01 ) on univariate analysis. eCC remained an independent predictor of adverse locoregional recurrence (HR 1.86, 95% CI 1.50\u20133.30, <jats:italic>P<\/jats:italic> = 0.03) and DFS (HR 1.30, 95% CI 0.88\u20131.92, <jats:italic>P<\/jats:italic> = 0.05) on multivariate analysis. eCC was not associated with adverse overall survival and systemic recurrence. eCC is an independent predictor of adverse locoregional recurrence and DFS.<\/jats:p>","DOI":"10.9738\/intsurg-d-13-00281.1","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T19:06:34Z","timestamp":1421435194000},"page":"77-86","source":"Crossref","is-referenced-by-count":48,"title":["Emergency Presenting Colon Cancer Is an Independent Predictor of Adverse Disease-Free Survival"],"prefix":"10.9738","volume":"100","author":[{"given":"John","family":"Hogan","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Samaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Hoong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoghan","family":"Condon","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Calvin","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, University Hospital Limerick, Ireland"},{"name":"Centre for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"7","key":"i0020-8868-100-1-77-b01","series-title":"Colorectal Dis","first-page":"663","article-title":"The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer","volume":"10","author":"Canna\n              K,","year":"2008","unstructured":"Canna\n              K, \n            \n              Hilmy\n              M, \n            \n              McMillan\n              DC, \n            \n              Smith\n              GW, \n            \n              McKee\n              RF, \n            \n              McArdle\n              CS\n            \n            et al\n          . The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Colorectal Dis2008;10(7):663\u2013667"},{"key":"i0020-8868-100-1-77-b02","article-title":"Bowel cancer statistics","year":"2014","unstructured":"Bowel Cancer UK. Bowel cancer statistics. Bowel Cancer UK. Available at: http:\/\/www.bowelcanceruk.org.uk\/resources\/bowel-cancer-facts-figures. Accessed March 31, 2014."},{"issue":"4","key":"i0020-8868-100-1-77-b03","series-title":"Dis Colon Rectum","first-page":"678","article-title":"Emergency first presentation of colorectal cancer predicts significantly poorer outcomes","volume":"52","author":"Bass\n              G,","year":"2009","unstructured":"Bass\n              G, \n            \n              Flemming\n              C, \n            \n              Conneely\n              J, \n            \n              Martin\n              M, \n            \n              Mealy\n              K. \n          \n          Emergency first presentation of colorectal cancer predicts significantly poorer outcomes. Dis Colon Rectum2009;52(4):678\u2013684"},{"issue":"6","key":"i0020-8868-100-1-77-b04","series-title":"World J Surg Oncol","first-page":"90","article-title":"Bucher P, Konrad B, Morel P. Results of emergency Hartmann's operation for obstructive or perforated left-sided colorectal cancer","volume":"23","author":"Charbonnet\n              P,","year":"2008","unstructured":"Charbonnet\n              P, \n            \n              Gervaz\n              P, \n            \n              Andres\n              A, \n          \n          Bucher P, Konrad B, Morel P. Results of emergency Hartmann's operation for obstructive or perforated left-sided colorectal cancer. World J Surg Oncol. 2008;23(6):90"},{"issue":"5","key":"i0020-8868-100-1-77-b05","series-title":"Br J Surg","first-page":"605","article-title":"Emergency presentation of colorectal cancer is associated with poor 5-year survival","volume":"91","author":"McArdle\n              CS,","year":"2004","unstructured":"McArdle\n              CS, \n            \n              Hole\n              DJ. \n          \n          Emergency presentation of colorectal cancer is associated with poor 5-year survival. Br J Surg2004;91(5):605\u2013609"},{"issue":"7","key":"i0020-8868-100-1-77-b06","series-title":"J Gastrointest Surg","first-page":"1213","article-title":"Clinicopathologic characteristics and outcomes of patients with obstructive colorectal cancer","volume":"15","author":"Zuli\n              Y,","year":"2011","unstructured":"Zuli\n              Y, \n            \n              Wang\n              L, \n            \n              Kang\n              L, \n            \n              Xiang\n              Y, \n            \n              Peng\n              J, \n            \n              Cui\n              J\n            \n            et al\n          . Clinicopathologic characteristics and outcomes of patients with obstructive colorectal cancer. J Gastrointest Surg2011;15(7):1213\u20131222"},{"issue":"8","key":"i0020-8868-100-1-77-b07","series-title":"Colorectal Dis","first-page":"775","article-title":"The impact of spontaneous tumor perforation on outcome following colon cancer surgery","volume":"10","author":"Abdelrazeq\n              AS,","year":"2008","unstructured":"Abdelrazeq\n              AS, \n            \n              Scott\n              N, \n            \n              Thorn\n              C, \n            \n              Verbeke\n              CS, \n            \n              Ambrose\n              NS, \n            \n              Botelli\n              ID\n            \n            et al\n          . The impact of spontaneous tumor perforation on outcome following colon cancer surgery. Colorectal Dis2008;10(8):775\u2013780"},{"key":"i0020-8868-100-1-77-b08","series-title":"BMC Cancer","first-page":"587","article-title":"Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin","volume":"10","author":"Pinheiro\n              M,","year":"2010","unstructured":"Pinheiro\n              M, \n            \n              Ahlquist\n              T, \n            \n              Danielsen\n              SA, \n            \n              Lind\n              GE, \n            \n              Veiga\n              I, \n            \n              Pinto\n              C\n            \n            et al\n          . Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin. BMC Cancer2010;10:587."},{"issue":"1","key":"i0020-8868-100-1-77-b09","series-title":"J Surg Oncol","first-page":"8","article-title":"Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival","volume":"97","author":"Rosenberg\n              R,","year":"2008","unstructured":"Rosenberg\n              R, \n            \n              Nekarda\n              H, \n            \n              Zimmermann\n              F, \n            \n              Becker\n              K, \n            \n              Lordick\n              F, \n            \n              Hofler\n              H\n            \n            et al\n          . Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival. 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Clin Cancer Res2004;10(12 Pt 1):4015\u20134021"},{"issue":"3","key":"i0020-8868-100-1-77-b12","series-title":"Am J Surg","first-page":"376","article-title":"Presentation, treatment, and multivariate analysis of risk factors for obstructive and perforative colorectal carcinoma","volume":"190","author":"Alvarez\n              JA,","year":"2005","unstructured":"Alvarez\n              JA, \n            \n              Baldonedo\n              RF, \n            \n              Bear\n              IG, \n            \n              Tru\u00e1n\n              N, \n            \n              Pire\n              G, \n            \n              Alvarez\n              P. \n          \n          Presentation, treatment, and multivariate analysis of risk factors for obstructive and perforative colorectal carcinoma. 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Surg Oncol2006;15(2):71\u201378"},{"issue":"2","key":"i0020-8868-100-1-77-b23","series-title":"Ann Surg Oncol","first-page":"434","article-title":"Loco-regional recurrence from colon cancer: a population based study","volume":"14","author":"Sjovall\n              A,","year":"2007","unstructured":"Sjovall\n              A, \n            \n              Granath\n              F, \n            \n              Cedermark\n              B, \n            \n              Glimelius\n              B, \n            \n              Holm\n              T. \n          \n          Loco-regional recurrence from colon cancer: a population based study. 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