{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:03Z","timestamp":1751485203888,"version":"3.41.0"},"reference-count":24,"publisher":"International College of Surgeons","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Cronkhite-Canada syndrome (CCS) is a very rare disease which may cause malignant transformation. A combination regimen including corticosteroids are common therapy for CCS, however the decrease of medicine may lead to CCS relapse and also may contribute to malignant transformation of the polyps in gastrointestinal tract. We retrospectively analyze one case of recurrent CCS from the first time of treatment after resection of colon cancer and readjust the usage of corticoids, the patient recovered well. The nine months follow-up showed non gastrointestinal tumor occurred or relapsed. We believe close follow-up should be taken when CCS patients are making medicine dosage alteration and tumor marker such as CEA may be included in the surveillance examination. When improvement using conservative treatment can be neither obtained nor is expected, the use of surgery should be considered.<\/jats:p>","DOI":"10.9738\/intsurg-d-14-00003.1","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T22:39:23Z","timestamp":1426718363000},"page":"402-407","source":"Crossref","is-referenced-by-count":6,"title":["A Case of Recurrent Cronkhite-Canada Syndrome Containing Colon Cancer"],"prefix":"10.9738","volume":"100","author":[{"given":"Xi","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Urology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Friendship Hospital affiliated with Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"24","key":"i0020-8868-100-3-402-b01","series-title":"N Engl J Med","first-page":"1011","article-title":"Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia","volume":"252","author":"Cronkhite\n              LJ,","year":"1955","unstructured":"Cronkhite\n              LJ, \n            \n              Canada\n              WJ. \n          \n          Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia. 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Gastric Cancer2000;3(3):156\u2013160"},{"issue":"2\u20133","key":"i0020-8868-100-3-402-b04","series-title":"Digestion","first-page":"96","article-title":"Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells","volume":"75","author":"Riegert-Johnson\n              DL,","year":"2007","unstructured":"Riegert-Johnson\n              DL, \n            \n              Osborn\n              N, \n            \n              Smyrk\n              T, \n            \n              Boardman\n              LA. \n          \n          Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells. Digestion2007;75(2\u20133):96\u201397"},{"issue":"5","key":"i0020-8868-100-3-402-b05","series-title":"Medicine (Baltimore)","first-page":"293","article-title":"The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients","volume":"61","author":"Daniel\n              ES,","year":"1982","unstructured":"Daniel\n              ES, \n            \n              Ludwig\n              SL, \n            \n              Lewin\n              KJ, \n            \n              Ruprecht\n              RM, \n            \n              Rajacich\n              GM, \n            \n              Schwabe\n              AD. \n          \n          The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. 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Gut Liver2009;3(4):271\u2013275"},{"issue":"8","key":"i0020-8868-100-3-402-b17","series-title":"J Gastroenterol","first-page":"791","article-title":"Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis","volume":"38","author":"Takeuchi\n              Y,","year":"2003","unstructured":"Takeuchi\n              Y, \n            \n              Yoshikawa\n              M, \n            \n              Tsukamoto\n              N, \n            \n              Shiroi\n              A, \n            \n              Hoshida\n              Y, \n            \n              Enomoto\n              Y\n            \n            et al\n          . Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. 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Am J Clin Pathol2005;123(3):329\u2013330"},{"issue":"3","key":"i0020-8868-100-3-402-b20","series-title":"Digestive Endoscopy","first-page":"255","article-title":"Diagnosis of neoplastic changes by magnifying colonoscopy in a patient with Cronkhite\u2013Canada Syndrome: a case report","volume":"12","author":"Satoh\n              H,","year":"2000","unstructured":"Satoh\n              H, \n            \n              Togashi\n              K, \n            \n              Konishi\n              F, \n            \n              Sakuma\n              K, \n            \n              Nagai\n              H. \n          \n          Diagnosis of neoplastic changes by magnifying colonoscopy in a patient with Cronkhite\u2013Canada Syndrome: a case report. 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