{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:03:32Z","timestamp":1785769412516,"version":"3.56.0"},"reference-count":13,"publisher":"International College of Surgeons","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>No reports have been published to date regarding primary gastric granulocyte colony\u2013stimulating factor (G-CSF)\u2013producing histiocytic sarcoma. We encountered a case of primary gastric histiocytic sarcoma that also fulfilled the criteria for a G-CSF\u2013producing tumor. A 75-year-old man was diagnosed with gastric cancer with poorly differentiated adenocarcinoma. The patient's white blood cell count was elevated to 20,700\/\u03bcL, and the G-CSF level was elevated to 380 pg\/mL. A computed tomography scan showed hepatic infiltration; therefore, a preoperative diagnosis of T4 (liver) N2H0M0 cStage IV gastric cancer was made, and surgery was performed. No. 11d lymphatic metastasis was noted, resulting in invasion of the pancreatic tail, and combined resection of the liver, pancreas, and spleen was conducted with complete gastrectomy. The results of hematoxylin-eosin and immunohistochemical staining were subsequently assessed. On discharge, the G-CSF level had fallen to 22.7 pg\/mL. Currently, the patient is still alive and has experienced no recurrence approximately 4 years after the operation.<\/jats:p>","DOI":"10.9738\/intsurg-d-14-00023.1","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T22:39:23Z","timestamp":1426718363000},"page":"568-573","source":"Crossref","is-referenced-by-count":10,"title":["A Case of G-CSF\u2013Producing Histiocytic Sarcoma of the Stomach"],"prefix":"10.9738","volume":"100","author":[{"given":"Toshiharu","family":"Hanaoka","sequence":"first","affiliation":[{"name":"Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Jingu","sequence":"additional","affiliation":[{"name":"Kuki General Hospital, Kuki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tochigi","sequence":"additional","affiliation":[{"name":"Kuki General Hospital, Kuki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Uematu","sequence":"additional","affiliation":[{"name":"Kuki General Hospital, Kuki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisahiro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"key":"i0020-8868-100-3-568-b01","series-title":"World Health Organization Classification of Tumours of Haematopoeitic and Lymphoid Tissues","first-page":"356","article-title":"Histiocytic sarcoma","author":"Grogan\n              TM,","year":"2008","unstructured":"Grogan\n              TM, \n            \n              Pileri\n              SA, \n            \n              Chan\n              JK, \n            \n              Weiss\n              LM, \n            \n              Fletcher\n              CD. \n          \n          Histiocytic sarcoma. In: SwerdlowSH, CampoE, HarrisNL, JaffeES, PileriSA, SteinHet al, eds. World Health Organization Classification of Tumours of Haematopoeitic and Lymphoid Tissues. Lyon, France: IARC Press2008:356\u2013357"},{"issue":"9","key":"i0020-8868-100-3-568-b02","series-title":"Am J Surg Pathol","first-page":"1133","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy","volume":"28","author":"Hornick\n              JL,","year":"2004","unstructured":"Hornick\n              JL, \n            \n              Jaffe\n              ES, \n            \n              Fletcher\n              CD. \n          \n          Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol2004;28(9):1133\u20131144"},{"issue":"5","key":"i0020-8868-100-3-568-b03","series-title":"Blood","first-page":"845","article-title":"Demonstration of granulopoietic factor in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue","volume":"49","author":"Asano\n              S,","year":"1977","unstructured":"Asano\n              S, \n            \n              Urabe\n              A, \n            \n              Okada\n              T, \n            \n              Sato\n              N, \n            \n              Kondo\n              Y. \n          \n          Demonstration of granulopoietic factor in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood1977;49(5):845\u2013852"},{"issue":"2","key":"i0020-8868-100-3-568-b04","series-title":"Gastric Cancer","first-page":"101","article-title":"Japanese classification of gastric carcinoma: 3rd English edition","volume":"14","author":"Sano\n              T","year":"2011","unstructured":"Sano\n              T\n            and KoderaY. \n          Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer2011;14(2):101\u2013112"},{"issue":"5","key":"i0020-8868-100-3-568-b05","series-title":"Ann Oncol","first-page":"397","article-title":"Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma","volume":"5","author":"Rohatiner\n              A,","year":"1994","unstructured":"Rohatiner\n              A, \n            \n              d'Amore\n              F, \n            \n              Coiffier\n              B, \n            \n              Crowther\n              D, \n            \n              Gospodarowicz\n              M, \n            \n              Isaacson\n              P\n            \n            et al\n          . Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol1994;5(5):397\u2013400"},{"issue":"2","key":"i0020-8868-100-3-568-b06","series-title":"J Histchem Cytochem","first-page":"283","article-title":"Establishment of specific monoclonal antibodies against recombinant human granulocyte colony-stimulating factor (hg-CSF) and their application for immunoperoxidase staining of paraffin embedded sections","volume":"38","author":"Shimamura\n              K,","year":"1990","unstructured":"Shimamura\n              K, \n            \n              Fujimoto\n              J, \n            \n              Hata\n              J, \n            \n              Akatsuka\n              A, \n            \n              Ueyama\n              Y, \n            \n              Watanabe\n              T\n            \n            et al\n          . Establishment of specific monoclonal antibodies against recombinant human granulocyte colony-stimulating factor (hg-CSF) and their application for immunoperoxidase staining of paraffin embedded sections. J Histchem Cytochem1990;38(2):283\u2013286"},{"issue":"4","key":"i0020-8868-100-3-568-b07","series-title":"Blood","first-page":"1033","article-title":"Nonhematopoietic tumor cells express functional GM-CSF receptors","volume":"73","author":"Baldwin\n              GC,","year":"1989","unstructured":"Baldwin\n              GC, \n            \n              Gasson\n              JC, \n            \n              Kaufman\n              SE, \n            \n              Quan\n              SG, \n            \n              Williams\n              RE, \n            \n              Avalos\n              BR\n            \n            et al\n          . Nonhematopoietic tumor cells express functional GM-CSF receptors. Blood1989;73(4):1033\u20131037"},{"issue":"3","key":"i0020-8868-100-3-568-b08","series-title":"World J Gastroenterol","first-page":"422","article-title":"Primary histiocytic sarcoma of the stomach: case report with imaging findings","volume":"19","author":"Shen\n              XZ,","year":"2013","unstructured":"Shen\n              XZ, \n            \n              Liu\n              F, \n            \n              Ni\n              RJ, \n            \n              Wang\n              BY. \n          \n          Primary histiocytic sarcoma of the stomach: case report with imaging findings. World J Gastroenterol2013;19(3):422\u2013425"},{"issue":"2","key":"i0020-8868-100-3-568-b09","series-title":"Int J Hematol","first-page":"247","article-title":"Synchronous histiocytic sarcoma and diffuse large B cell lymphoma involving the stomach: a case report and review of the literature","volume":"93","author":"Congyang\n              L,","year":"2011","unstructured":"Congyang\n              L, \n            \n              Xinqqui\n              W, \n            \n              Hao\n              L, \n            \n              Weihua\n              H. \n          \n          Synchronous histiocytic sarcoma and diffuse large B cell lymphoma involving the stomach: a case report and review of the literature. Int J Hematol2011;93(2):247\u2013252"},{"issue":"4","key":"i0020-8868-100-3-568-b10","series-title":"Jpn J Cancer Res","first-page":"440","article-title":"In vivo tumor growth enhancement by granulocyte colony-stimulating factor","volume":"82","author":"Segawa\n              K,","year":"1991","unstructured":"Segawa\n              K, \n            \n              Ueno\n              Y, \n            \n              Kataoka\n              T. \n          \n          In vivo tumor growth enhancement by granulocyte colony-stimulating factor. Jpn J Cancer Res1991;82(4):440\u2013447"},{"key":"i0020-8868-100-3-568-b11","series-title":"Esophagus","first-page":"258","article-title":"Granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma following chemoradiotherapy and bone marrow transplantation for acute lymphoblastic leukemia","volume":"10","author":"Mayanagi\n              S,","year":"2013","unstructured":"Mayanagi\n              S, \n            \n              Niihara\n              M, \n            \n              Goto\n              H, \n            \n              Yokota\n              T, \n            \n              Tabuse\n              H, \n            \n              Yasui\n              H\n            \n            et al\n          . Granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma following chemoradiotherapy and bone marrow transplantation for acute lymphoblastic leukemia. Esophagus2013;10:258\u2013263"},{"issue":"12","key":"i0020-8868-100-3-568-b12","series-title":"Gan To Kagaku Ryoho","first-page":"2330","article-title":"Locally advanced granulocyte colony-stimulating factor-producing non-small cell lung cancer successfully treated with concurrent chemoradiotherapy","volume":"40","author":"Yokosuka\n              T,","year":"2013","unstructured":"Yokosuka\n              T, \n            \n              Enomoto\n              T, \n            \n              Takeda\n              A, \n            \n              Kobayashi\n              T. \n          \n          Locally advanced granulocyte colony-stimulating factor-producing non-small cell lung cancer successfully treated with concurrent chemoradiotherapy. Gan To Kagaku Ryoho2013;40(12):2330\u20132332"},{"issue":"10","key":"i0020-8868-100-3-568-b13","series-title":"Jpn J Clin Oncol","first-page":"793","article-title":"Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor","volume":"37","author":"Yamano\n              T,","year":"2007","unstructured":"Yamano\n              T, \n            \n              Morii\n              E, \n            \n              Ikeda\n              J, \n            \n              Aozasa\n              K. \n          \n          Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor. Jpn J Clin Oncol2007;37(10):793\u2013796"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/100\/3\/article-p568.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/100\/3\/568\/2205476\/intsurg-d-14-00023_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/100\/3\/article-p568.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/100\/3\/article-p568.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:07:40Z","timestamp":1751483260000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/100\/3\/article-p568.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":13,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-14-00023.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"value":"0020-8868","type":"print"},{"value":"2520-2456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}