{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:44:09Z","timestamp":1789562649429,"version":"build-2803163510"},"reference-count":21,"publisher":"International College of Surgeons","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including the data of 22 patients with PSRCCR who underwent surgery. Patients were categorized by age, sex, tumor site, and stage. Fifteen patients were male. Median age was 40 years. Sites for metastases were lymph nodes (86.4%), peritoneum (40.9%), and liver (9.1%). Most of the patients (91%) had stage III or IV tumors. The rates of curative and palliative resections performed were equal. Mean overall survival and mean progression-free survival times were found to be 33.3 \u00b1 7.1 months (95% confidence interval, 19.4\u201347.2 months) and 11.8 \u00b1 3.5 months (95% confidence interval, 4.9\u201318.7 months), respectively. It was concluded that site of the tumor, presence of bowel obstruction, peritoneum and lung metastases, adjacent organ infiltration, TNM stage, and efficiency of surgery have significant effects on survival. All in all, these aggressive tumors are generally diagnosed at advanced stages. Depending on the situation, survival is shorter. A high degree of vigilance is required for these patients to avoid the negative impact of late diagnosis on survival.<\/jats:p>","DOI":"10.9738\/intsurg-d-14-00067.1","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:06:49Z","timestamp":1417478809000},"page":"691-698","source":"Crossref","is-referenced-by-count":41,"title":["Outcomes of Surgical Treatment of Primary Signet Ring Cell Carcinoma of the Colon and Rectum: 22 Cases Reviewed With Literature"],"prefix":"10.9738","volume":"99","author":[{"given":"Sedat","family":"Belli","sequence":"first","affiliation":[{"name":"Department of Surgery, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin Ozgur","family":"Aytac","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Karagulle","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Yabanoglu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazilet","family":"Kayaselcuk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baskent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"8","key":"i0020-8868-99-6-691-b01","series-title":"Cancer","first-page":"1453","article-title":"Primary signet-ring carcinoma of the colon","volume":"52","author":"Almagro\n              UA.","year":"1983","unstructured":"Almagro\n              UA. \n          \n          Primary signet-ring carcinoma of the colon. 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Dis Colon Rectum2005;48(6):1161\u20131168"},{"issue":"93","key":"i0020-8868-99-6-691-b03","series-title":"Hepatogastroenterology","first-page":"984","article-title":"Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study","volume":"56","author":"Min\n              BS,","year":"2009","unstructured":"Min\n              BS, \n            \n              Kim\n              NK, \n            \n              Ko\n              YT, \n            \n              Baek\n              SH, \n            \n              Lee\n              KY, \n            \n              Sohn\n              SK. \n          \n          Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study. Hepatogastroenterology2009;56(93):984\u2013988"},{"issue":"3","key":"i0020-8868-99-6-691-b04","series-title":"Rev Gastroenterol Peru","first-page":"234","article-title":"Colon and rectum signet-ring cell carcinoma in the National Institute of Neoplastic Diseases","volume":"24","author":"Casavilca Zambrano","year":"2004","unstructured":"Casavilca Zambrano\n              S\n            , Sanchez LihonJ, ZavaletaA. Colon and rectum signet-ring cell carcinoma in the National Institute of Neoplastic Diseases. Rev Gastroenterol Peru2004;24(3):234\u2013237"},{"issue":"2","key":"i0020-8868-99-6-691-b05","series-title":"J Am Coll Surg","first-page":"188","article-title":"Surgical pathology of colorectal cancer in Filipinos: implications for clinical practice","volume":"195","author":"Kaw\n              LL\n              Jr,","year":"2002","unstructured":"Kaw\n              LL\n              Jr, \n            \n              Punzalan\n              CK, \n            \n              Crisostomo\n              AC, \n            \n              Bowyer\n              MW, \n            \n              Wherry\n              DC. \n          \n          Surgical pathology of colorectal cancer in Filipinos: implications for clinical practice. J Am Coll Surg2002;195(2):188\u2013195"},{"issue":"3","key":"i0020-8868-99-6-691-b06","series-title":"Cancer","first-page":"816","article-title":"Colorectal adenocarcinoma in young Lebanese adults: the American University of Beirut-Medical Center experience with 32 patients","volume":"58","author":"Ibrahim\n              NK,","year":"1986","unstructured":"Ibrahim\n              NK, \n            \n              Abdul-Karim\n              FW. \n          \n          Colorectal adenocarcinoma in young Lebanese adults: the American University of Beirut-Medical Center experience with 32 patients. Cancer1986;58(3):816\u2013820"},{"issue":"12","key":"i0020-8868-99-6-691-b07","series-title":"Dis Colon Rectum","first-page":"1618","article-title":"Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage","volume":"42","author":"Psathakis\n              D,","year":"1999","unstructured":"Psathakis\n              D, \n            \n              Schiedeck\n              TH, \n            \n              Krug\n              F, \n            \n              Oevermann\n              E, \n            \n              Kujath\n              P, \n            \n              Bruch\n              HP. \n          \n          Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage. Dis Colon Rectum1999;42(12):1618\u20131625"},{"key":"i0020-8868-99-6-691-b08","series-title":"Histological Typing of Intestinal Tumours. 2nd ed","author":"Jass\n              JR,","year":"1989","unstructured":"Jass\n              JR, \n            \n              Sobin\n              LH. \n          \n          Histological Typing of Intestinal Tumours. 2nd ed. Berlin, Germany: Springer;1989"},{"key":"i0020-8868-99-6-691-b09","series-title":"AJCC Cancer Staging Handbook. 7th ed","author":"Edge\n              SB,","year":"2010","unstructured":"Edge\n              SB, \n            \n              Byrd\n              DR, \n            \n              Compton\n              CC, \n            \n              Fritz\n              AG, \n            \n              Greene\n              FL, \n            \n              Trotti\n              A. \n          \n          AJCC Cancer Staging Handbook. 7th ed. New York, NY: Springer;2010"},{"issue":"4","key":"i0020-8868-99-6-691-b10","series-title":"Ann Surg Oncol","first-page":"344","article-title":"Primary signet-ring cell carcinoma of the colon and rectum","volume":"3","author":"Anthony\n              T,","year":"1996","unstructured":"Anthony\n              T, \n            \n              George\n              R, \n            \n              Rodriguez-Bigas\n              M, \n            \n              Petrelli\n              NJ. \n          \n          Primary signet-ring cell carcinoma of the colon and rectum. 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Int J Cancer1999;84(1):33\u201338"},{"issue":"3","key":"i0020-8868-99-6-691-b15","series-title":"Int J Colorectal Dis","first-page":"371","article-title":"Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon","volume":"27","author":"Ishihara\n              S,","year":"2012","unstructured":"Ishihara\n              S, \n            \n              Watanabe\n              T, \n            \n              Akahane\n              T, \n            \n              Shimada\n              R, \n            \n              Horiuchi\n              A, \n            \n              Shibuya\n              H. \n          \n          Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon. 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Hepatogastroenterology2006;53(72):845\u2013849"},{"issue":"1","key":"i0020-8868-99-6-691-b18","series-title":"Asian Pac J Cancer Prev","first-page":"279","article-title":"Anatomical distribution of colorectal carcinoma in Iran: a retrospective 15-yr study to evaluate rightward shift","volume":"13","author":"Omranipour\n              R,","year":"2012","unstructured":"Omranipour\n              R, \n            \n              Doroudian\n              R, \n            \n              Mahmoodzadeh\n              H. \n          \n          Anatomical distribution of colorectal carcinoma in Iran: a retrospective 15-yr study to evaluate rightward shift. 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