{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:18:54Z","timestamp":1781266734525,"version":"3.54.1"},"reference-count":28,"publisher":"International College of Surgeons","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a radical but effective treatment option for select peritoneal malignancies. We sought to determine our early experience with this method for peritoneal carcinomatosis secondary to mucinous adenocarcinomas of appendiceal origin. As such, we performed a retrospective clinical study of 30 consecutive patients undergoing CRS with planned HIPEC at the Princess Alexandra Hospital, between June 2009 to December 2012, with mucinous adenocarcinomas of the appendix. CRS was performed in 30 patients, 13 received HIPEC intraoperatively and 17 received early postoperative intra-peritoneal chemotherapy (EPIC) in addition. Mean age was 52.3 years and median hospital stay was 26 days (range 12\u2013190 days). Peritoneal cancer index scores were 0\u201310 in 6.7% of patients, 11\u201320 in 20% of patients and &gt;20 in 73.3% of patients. Complete cytoreduction was achieved overall in 21 patients. In total, 106 complications were observed in 28 patients. Ten were grade 3-A, five were grade 3-B and one grade-5 secondary to a fatal PE on day 97. In patients who received HIPEC, there was no difference in disease-free survival (<jats:italic>P<\/jats:italic> = 0.098) or overall survival (<jats:italic>P<\/jats:italic> = 0.645) between those who received EPIC versus those who did not. This study demonstrates that satisfactory outcomes with regards to morbidity and survival can be achieved with CRS and HIPEC, at a single-centre institution with growing expertise in the technique. Our results are comparable with outcomes previously described in the international literature.<\/jats:p>","DOI":"10.9738\/intsurg-d-14-00089.1","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T19:06:34Z","timestamp":1421435194000},"page":"21-28","source":"Crossref","is-referenced-by-count":11,"title":["Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis Secondary to Mucinous Adenocarcinoma of the Appendix"],"prefix":"10.9738","volume":"100","author":[{"given":"David S.","family":"Sparks","sequence":"first","affiliation":[{"name":"Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia"},{"name":"School of Medicine, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Fulton","sequence":"additional","affiliation":[{"name":"Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Oncology, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Meade","sequence":"additional","affiliation":[{"name":"Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Lutton","sequence":"additional","affiliation":[{"name":"Department of Surgery, Princess Alexandra Hospital, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"issue":"1","key":"i0020-8868-100-1-21-b01","series-title":"Lancet Oncol","first-page":"69","article-title":"New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?","volume":"7","author":"Sugarbaker\n              PH.","year":"2006","unstructured":"Sugarbaker\n              PH. \n          \n          New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?\n          Lancet Oncol\n          2006;7(1):69\u201376"},{"issue":"20","key":"i0020-8868-100-1-21-b02","series-title":"J Clin Oncol","first-page":"2449","article-title":"Early and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"30","author":"Chua\n              TC,","year":"2012","unstructured":"Chua\n              TC, \n            \n              Moran\n              BJ, \n            \n              Sugarbaker\n              PH, \n            \n              Levine\n              EA, \n            \n              Glehen\n              O, \n            \n              Gilly\n              FN\n            \n            et al\n          . Early and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol2012;30(20):2449\u20132456"},{"issue":"3","key":"i0020-8868-100-1-21-b03","series-title":"Cancer Invest","first-page":"209","article-title":"Peritoneal carcinomatosis: cytoreductive surgery and HIPEC\u2013overview and basics","volume":"30","author":"Br\u00fccher\n              BLDM,","year":"2012","unstructured":"Br\u00fccher\n              BLDM, \n            \n              Piso\n              P, \n            \n              Verwaal\n              V, \n            \n              Esquivel\n              J, \n            \n              Derraco\n              M, \n            \n              Yonemura\n              Y\n            \n            et al\n          . Peritoneal carcinomatosis: cytoreductive surgery and HIPEC\u2013overview and basics. Cancer Invest2012;30(3):209\u2013224"},{"issue":"6","key":"i0020-8868-100-1-21-b04","series-title":"J Surg Oncol","first-page":"591","article-title":"HIPEC\u2009+\u2009EPIC versus HIPEC-alone: differences in major complications following cytoreduction surgery for peritoneal malignancy","volume":"107","author":"McConnell\n              YJ,","year":"2013","unstructured":"McConnell\n              YJ, \n            \n              Mack\n              LA, \n            \n              Francis\n              WP, \n            \n              Ho\n              T, \n            \n              Temple\n              WJ. \n          \n          HIPEC\u2009+\u2009EPIC versus HIPEC-alone: differences in major complications following cytoreduction surgery for peritoneal malignancy. 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Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion. J Surg Oncol2008;98(4):242\u2013246"},{"issue":"2","key":"i0020-8868-100-1-21-b13","series-title":"Ann Surg","first-page":"205","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo\n              D,","year":"2004","unstructured":"Dindo\n              D, \n            \n              Demartines\n              N, \n            \n              Clavien\n              PA. \n          \n          Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. 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Dis Colon Rectum2009;52(10):1705\u20131714"},{"issue":"3","key":"i0020-8868-100-1-21-b24","series-title":"Int J Clin Oncol","first-page":"439","article-title":"Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal peritoneal carcinomatosis","volume":"18","author":"Chua\n              TC,","year":"2013","unstructured":"Chua\n              TC, \n            \n              Liauw\n              W, \n            \n              Zhao\n              J, \n            \n              Morris\n              DL. \n          \n          Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal peritoneal carcinomatosis. 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