{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:21:43Z","timestamp":1789842103042,"version":"4.0.1"},"reference-count":25,"publisher":"International College of Surgeons","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>The aim of our study was to evaluate the relationship between neutrophil to lymphocyte ratio (NLR) and adenoma size in parathyroidectomized patients who underwent a parathyroidectomy. The neutrophil to lymphocyte ratio has recently become popular as a biomarker for malignant diseases or for estimating tumor size preoperatively. This study aimed to estimate the relationship between adenoma size and NLR. Furthermore, we assessed whether a higher level of NLR is correlated with the presence of parathyroid carcinoma. A retrospective chart review was performed for patients with parathyroid adenoma who underwent parathyroidectomy between January 2012 and August 2014. Data related to age, sex, NLR, parathyroid hormone level (PTH), preoperative calcium, phosphorus, adenoma size, and pathology reports were collected. The neutrophil to lymphocyte ratio was significantly correlated with calcium levels, PTH levels, parathyroid adenoma size, and the presence of cancer. However, there was no correlation between NLR and age, sex, and phosphorus levels. This study is the first to document a positive correlation between NLR and parathyroid adenoma size, as well as the presence of cancer, in patients who underwent surgery as a result of primary hyperparathyroidism.<\/jats:p>","DOI":"10.9738\/intsurg-d-15-00044.1","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T19:38:25Z","timestamp":1448307505000},"page":"1185-1189","source":"Crossref","is-referenced-by-count":14,"title":["Relationship Between the Neutrophil to Lymphocyte Ratio and Parathyroid Adenoma Size in Patients With Primary Hyperparathyroidism"],"prefix":"10.9738","volume":"100","author":[{"given":"Sezgin","family":"Zeren","sequence":"first","affiliation":[{"name":"Dumlupinar University, Faculty of Medicine, Department of General Surgery, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faik","family":"Yaylak","sequence":"additional","affiliation":[{"name":"Dumlupinar University, Faculty of Medicine, Department of General Surgery, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa","family":"Ozbay","sequence":"additional","affiliation":[{"name":"Dumlupinar University, Faculty of Medicine, Department of Otorhinolaryngology, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfu","family":"Bayhan","sequence":"additional","affiliation":[{"name":"Dumlupinar University, Faculty of Medicine, Department of General Surgery, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4721","reference":[{"key":"i0020-8868-100-7-1185-b01","series-title":"J Otolaryngol Head Neck Surg","first-page":"44","article-title":"Surgical management of primary hyperparathyroidism in Canada","volume":"43","author":"Williams\n              BA,","year":"2014","unstructured":"Williams\n              BA, \n            \n              Trites\n              JR, \n            \n              Taylor\n              SM, \n            \n              Bullock\n              MJ, \n            \n              Hart\n              RD.\n            \n          \n          Surgical management of primary hyperparathyroidism in Canada. 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J Korean Med Sci2012;27(8):890\u2013895"},{"issue":"10","key":"i0020-8868-100-7-1185-b20","series-title":"World J Surg","first-page":"2605","article-title":"Does preoperative neutrophil lymphocyte ratio predict risk of recurrence and occult central nodal metastasis in papillary thyroid carcinoma?","volume":"38","author":"Lang\n              BH,","year":"2014","unstructured":"Lang\n              BH, \n            \n              Ng\n              CP, \n            \n              Au\n              KB, \n            \n              Wong\n              KP, \n            \n              Wong\n              KK, \n            \n              Wan\n              KY.\n            \n          \n          Does preoperative neutrophil lymphocyte ratio predict risk of recurrence and occult central nodal metastasis in papillary thyroid carcinoma?\n          World J Surg\n          2014;38(10):2605\u20132612"},{"issue":"1","key":"i0020-8868-100-7-1185-b21","series-title":"Future Oncol","first-page":"149","article-title":"Role of systemic inflammatory response in predicting survival in patients with primary operable cancer","volume":"6","author":"Roxburgh\n              CS,","year":"2010","unstructured":"Roxburgh\n              CS, \n            \n              McMillan\n              DC.\n            \n          \n          Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. 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