{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:40:06Z","timestamp":1751485206730,"version":"3.41.0"},"reference-count":17,"publisher":"International College of Surgeons","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>We aimed to evaluate the frequency of the need for proton pump inhibitor treatment following laparoscopic Nissen fundoplication (LNF) for gastroesophageal reflux disease (GERD). A total of 162 patients with GERD were treated surgically with LNF from October 2006 to March 2010 in our surgery department. Diagnoses were made by using upper gastrointestinal system (GIS) endoscopy and 24-hour pH monitoring, and all the patients underwent routine LNF surgery. The patients were questioned regarding complaints and proton pump inhibitor (PPI) usage during the postoperative period, and 40 patients who had postoperative GIS symptoms were included. Upper GIS endoscopy with antral biopsy for <jats:italic>Helicobacter pylori<\/jats:italic> (HP) identification and multichannel intraluminal impedance pH (MII-pH) monitoring were applied, and all the data were evaluated. The median postoperative follow-up time was 1.84 \u00b1 0.850 (0.29\u20133.48) years. PPI treatment frequency was 37.5% (15 patients) in the 40 symptomatic patients, or 9.26% in all 162 patients who were operated on. The reason for PPI usage in 3 patients (7.5%) was regarded as recurrence. HP positivity was 67.5% in the symptomatic patients and 73.3% in the PPI treated group; 40% (6 patients) recovery was achieved in the HP (+) patients by using an HP eradication treatment protocol. The operated patients displayed statistically significant results in increased quality of life (<jats:italic>P<\/jats:italic> = 0.001) and lowered DeMeester scores (<jats:italic>P<\/jats:italic> = 0.000) during the postoperative period when compared with the preoperative period. LNF treatment for GERD prevents pathologic reflux in the long term and maintains symptomatic control, which leads to increased and better quality of life. PPI treatment alone during the postoperative period does not indicate \u201crecurrence.\u201d One of the most important reasons for recurrence is antral gastritis secondary to HP infection; PPI usage diminishes remarkably with an HP eradication protocol. MII-pH monitoring is an effective method of determining recurrences due to reflux and their types in postoperative symptomatic patients.<\/jats:p>","DOI":"10.9738\/intsurg-d-15-00217.1","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T19:07:54Z","timestamp":1458760074000},"page":"98-103","source":"Crossref","is-referenced-by-count":1,"title":["Laparoscopic Nissen Fundoplication: Analysis of 162 Patients"],"prefix":"10.9738","volume":"101","author":[{"given":"Alpaslan","family":"Sari","sequence":"first","affiliation":[{"name":"Department of General Surgery, Kocaeli Seka State Hospital, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neset Nuri","family":"Gonullu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kocaeli University, School of Medical, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagri","family":"Tiryaki","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat Burc","family":"Yazicioglu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertugrul","family":"Kargi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Abant \u0130zzet Baysal University, School of Medical, Bolu, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Gonullu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Eskisehir State Hospital, Eskisehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Oktay","family":"Yirmibesoglu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kocaeli University, School of Medical, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4721","reference":[{"issue":"3","key":"i0020-8868-101-1-98-b01","series-title":"Arq Bras Cir Dig","first-page":"210","article-title":"Diagnosis and management of gastroesophageal reflux disease [in English, Portuguese]","volume":"27","author":"Henry \n              MA.","year":"2014","unstructured":"Henry \n              MA. \n            \n          \n          Diagnosis and management of gastroesophageal reflux disease [in English, Portuguese]. Arq Bras Cir Dig2014;27(3):210\u2013215"},{"issue":"1","key":"i0020-8868-101-1-98-b02","series-title":"World J Surg","first-page":"208","article-title":"Effectiveness of antireflux surgery for the cure of chronic cough associated with gastroesophageal reflux disease","volume":"39","author":"Lugaresi \n              M,","year":"2015","unstructured":"Lugaresi \n              M, \n            \n            \n              Aramini \n              B, \n            \n            \n              Daddi \n              N, \n            \n            \n              Baldi \n              F, \n            \n            \n              Mattioli \n              S. \n            \n          \n          Effectiveness of antireflux surgery for the cure of chronic cough associated with gastroesophageal reflux disease. World J Surg2015;39(1):208\u2013215"},{"issue":"5","key":"i0020-8868-101-1-98-b03","series-title":"Duodecim","first-page":"475","article-title":"[Antireflux surgery more cost-effective than medication after all? (in Finnish)]","volume":"130","author":"Rantanen \n              T.","year":"2014","unstructured":"Rantanen \n              T. \n            \n          \n          [Antireflux surgery more cost-effective than medication after all? (in Finnish)]. Duodecim2014;130(5):475\u2013481"},{"issue":"24","key":"i0020-8868-101-1-98-b04","series-title":"World J Gastroenterol","first-page":"3810","article-title":"Quality of life following laparoscopic Nissen fundoplication: assessing short-term and long-term outcomes","volume":"19","author":"Kellokumpu \n              I,","year":"2013","unstructured":"Kellokumpu \n              I, \n            \n            \n              Voutilainen \n              M, \n            \n            \n              Haglund \n              C, \n            \n            \n              Farkkila \n              M, \n            \n            \n              Roberts \n              PJ, \n            \n            \n              Kautiainen \n              H. \n            \n          \n          Quality of life following laparoscopic Nissen fundoplication: assessing short-term and long-term outcomes. 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Br J Surg2000;87(7):873\u2013878"},{"issue":"1","key":"i0020-8868-101-1-98-b07","series-title":"Gut","first-page":"8","article-title":"Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients","volume":"35","author":"Kuster \n              E,","year":"1994","unstructured":"Kuster \n              E, \n            \n            \n              Ros \n              E, \n            \n            \n              Toledo-Pimentel \n              V, \n            \n            \n              Pujol \n              A, \n            \n            \n              Bordas \n              JM, \n            \n            \n              Grande \n              L\n            \n            et al. \n          Predictive factors of the long term outcome in gastro-oesophageal reflux disease: six year follow up of 107 patients. Gut1994;35(1):8\u201314"},{"issue":"7","key":"i0020-8868-101-1-98-b08","series-title":"J Gastroint Surg","first-page":"890","article-title":"Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology","volume":"8","author":"Tamhankar \n              AP,","year":"2004","unstructured":"Tamhankar \n              AP, \n            \n            \n              Peters \n              JH, \n            \n            \n              Portale \n              G, \n            \n            \n              Hsieh \n              CC, \n            \n            \n              Hagen \n              JA, \n            \n            \n              Bremner \n              CG\n            \n            et al. \n          Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology. J Gastroint Surg2004;8(7):890\u2013897; discussion 7\u20138"},{"issue":"9","key":"i0020-8868-101-1-98-b09","series-title":"Can J Gastroenterol","first-page":"627","article-title":"Motion\u2013Laparoscopic Nissen fundoplication is more cost effective than oral PPI administration: arguments against the motion","volume":"16","author":"Sonnenberg \n              A.","year":"2002","unstructured":"Sonnenberg \n              A. \n            \n          \n          Motion\u2013Laparoscopic Nissen fundoplication is more cost effective than oral PPI administration: arguments against the motion. Can J Gastroenterol2002;16(9):627\u2013631"},{"issue":"11","key":"i0020-8868-101-1-98-b10","series-title":"Am J Gastroenterol","first-page":"2457","article-title":"Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease","volume":"101","author":"Labenz \n              J,","year":"2006","unstructured":"Labenz \n              J, \n            \n            \n              Nocon \n              M, \n            \n            \n              Lind \n              T, \n            \n            \n              Leodolter \n              A, \n            \n            \n              Jaspersen \n              D, \n            \n            \n              Meyer-Sabellek \n              W\n            \n            et al. \n          Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial disease. Am J Gastroenterol2006;101(11):2457\u20132462"},{"issue":"9","key":"i0020-8868-101-1-98-b11","series-title":"Surg Endosc","first-page":"1938","article-title":"The use of medication after laparoscopic antireflux surgery","volume":"23","author":"Ciovica \n              R,","year":"2009","unstructured":"Ciovica \n              R, \n            \n            \n              Riedl \n              O, \n            \n            \n              Neumayer \n              C, \n            \n            \n              Lechner \n              W, \n            \n            \n              Schwab \n              GP, \n            \n            \n              Gadenstatter \n              M. \n            \n          \n          The use of medication after laparoscopic antireflux surgery. 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Arch Surg2008;143(5):482\u2013487"},{"issue":"8","key":"i0020-8868-101-1-98-b13","series-title":"Surg Endosc","first-page":"1200","article-title":"Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy","volume":"17","author":"Papasavas \n              PK,","year":"2003","unstructured":"Papasavas \n              PK, \n            \n            \n              Keenan \n              RJ, \n            \n            \n              Yeaney \n              WW, \n            \n            \n              Caushaj \n              PF, \n            \n            \n              Gagne \n              DJ, \n            \n            \n              Landreneau \n              RJ. \n            \n          \n          Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy. Surg Endosc2003;17(8):1200\u20131205"},{"issue":"3","key":"i0020-8868-101-1-98-b14","series-title":"J Gastrointest Surg","first-page":"510","article-title":"Use of antireflux medication after antireflux surgery","volume":"12","author":"Wijnhoven \n              BP,","year":"2008","unstructured":"Wijnhoven \n              BP, \n            \n            \n              Lally \n              CJ, \n            \n            \n              Kelly \n              JJ, \n            \n            \n              Myers \n              JC, \n            \n            \n              Watson \n              DI. \n            \n          \n          Use of antireflux medication after antireflux surgery. J Gastrointest Surg2008;12(3):510\u2013517"},{"issue":"3","key":"i0020-8868-101-1-98-b15","series-title":"Scand J Surg","first-page":"227","article-title":"Long-term results of laparoscopic Nissen fundoplication due to gastroesophageal reflux disease. A ten year follow-up in a low volume center","volume":"97","author":"Kornmo \n              TS,","year":"2008","unstructured":"Kornmo \n              TS, \n            \n            \n              Ruud \n              TE. \n            \n          \n          Long-term results of laparoscopic Nissen fundoplication due to gastroesophageal reflux disease. A ten year follow-up in a low volume center. Scand J Surg2008;97(3):227\u2013230"},{"issue":"5","key":"i0020-8868-101-1-98-b16","series-title":"Aliment Pharmacol Ther","first-page":"601","article-title":"Despite high satisfaction, majority of gastro-oesophageal reflux disease patients continue to use proton pump inhibitors after antireflux surgery","volume":"23","author":"Madan \n              A,","year":"2006","unstructured":"Madan \n              A, \n            \n            \n              Minocha \n              A. \n            \n          \n          Despite high satisfaction, majority of gastro-oesophageal reflux disease patients continue to use proton pump inhibitors after antireflux surgery. Aliment Pharmacol Ther2006;23(5):601\u2013605."},{"issue":"3","key":"i0020-8868-101-1-98-b17","series-title":"Gastroenterol Clin North Am","first-page":"713","article-title":"Complications of reflux esophagitis and their medical management","volume":"19","author":"Kozarek \n              RA.","year":"1990","unstructured":"Kozarek \n              RA. \n            \n          \n          Complications of reflux esophagitis and their medical management. Gastroenterol Clin North Am1990;19(3):713\u2013731"}],"container-title":["International Surgery"],"original-title":[],"link":[{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/101\/1-2\/article-p98.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/international-surgery\/article-pdf\/101\/1-2\/98\/2347276\/intsurg-d-15-00217_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/101\/1-2\/article-p98.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/international-surgery.kglmeridian.com\/downloadpdf\/journals\/insu\/101\/1-2\/article-p98.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:00:40Z","timestamp":1751482840000},"score":1,"resource":{"primary":{"URL":"https:\/\/international-surgery.kglmeridian.com\/view\/journals\/insu\/101\/1-2\/article-p98.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":17,"journal-issue":{"issue":"1-2"},"URL":"https:\/\/doi.org\/10.9738\/intsurg-d-15-00217.1","relation":{},"ISSN":["0020-8868","2520-2456"],"issn-type":[{"type":"print","value":"0020-8868"},{"type":"electronic","value":"2520-2456"}],"subject":[],"published":{"date-parts":[[2016]]}}}