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A number of patients utilize CAM for the treatment of depression; however, as there is limited scientific evidence, the safety profile of these supplements are largely unknown. In this case, a 42-year-old man developed hypomania approximately 1 week after S-adenosylmethionine (SAMe) and 5-hydroxytryptophan (5-HTP) therapy was initiated for depression. The combination of SAMe and 5-HTP can potentially induce hypomanic episodes.<\/jats:p>","DOI":"10.9740\/mhc.2017.07.160","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T13:46:48Z","timestamp":1499089608000},"page":"160-163","source":"Crossref","is-referenced-by-count":5,"title":["Treatment-emergent hypomania possibly associated with over-the-counter supplements"],"prefix":"10.9740","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6258-8653","authenticated-orcid":false,"given":"William","family":"Olsufka","sequence":"first","affiliation":[{"name":"(Corresponding author) Assistant Professor of Pharmacy Practice, Mount Sinai Beth Israel\/Touro College of Pharmacy, New York, New York, william.olsufka@touro.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-5774","authenticated-orcid":false,"given":"Mary-Ann","family":"Abraham","sequence":"first","affiliation":[{"name":"PGY1 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