{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:53:00Z","timestamp":1770151980591,"version":"3.49.0"},"reference-count":15,"publisher":"American Association of Psychiatric Pharmacists (AAPP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Designer products, a term referring to analogs of known chemical compounds with no established medical use, represent an easily accessible alternative to prescription-only products. During the past decade, designer benzodiazepines have become widely available on the online forums. Although these agents offer individuals an inexpensive and accessible alternative to prescription-only products, they are not without risk. Because of the lack of federally enforced quality standards, these designer products come with an intrinsic risk of unpredictable and potentially toxic adverse effects. This article presents a 36-year-old male with prolonged bradycardia resulting from the use of flubromazolam, a designer benzodiazepine purchased from the Internet. A PubMed search was conducted for flubromazolam, designer benzodiazepine, and flumazenil. This article will summarize the available literature regarding flubromazolam and the role of flumazenil in managing these overdoses.<\/jats:p>","DOI":"10.9740\/mhc.2019.05.133","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T13:43:39Z","timestamp":1557495819000},"page":"133-137","source":"Crossref","is-referenced-by-count":23,"title":["Flubromazolam overdose: A review of a new designer benzodiazepine and the role of flumazenil"],"prefix":"10.9740","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-8420","authenticated-orcid":false,"given":"Kristin","family":"Bohnenberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-9319","authenticated-orcid":false,"given":"Mei T.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4719","reference":[{"issue":"10","key":"2020060307353569900_i2168-9709-9-3-133-b01","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/15563650.2017.1388087","article-title":"2016 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 34th annual report","volume":"55","author":"Gummin","year":"2017","journal-title":"Clin Toxicol (Phila)"},{"issue":"1","key":"2020060307353569900_i2168-9709-9-3-133-b02","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/dta.2203","article-title":"Flubromazolam--basic pharmacokinetic evaluation of a highly potent designer benzodiazepine","volume":"10","author":"Huppertz","year":"2017","journal-title":"Drug Test Anal"},{"issue":"2","key":"2020060307353569900_i2168-9709-9-3-133-b03","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/wps.20236","article-title":"Designer benzodiazepines: a new challenge","volume":"14","author":"Moosmann","year":"2015","journal-title":"World Psychiatry"},{"issue":"1","key":"2020060307353569900_i2168-9709-9-3-133-b04","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3109\/15563650.2015.1112907","article-title":"Flubromazolam--a new life-threatening designer benzodiazepine","volume":"54","author":"\u0141ukasik-G\u0142\u0119bocka","year":"2016","journal-title":"Clin Toxicol"},{"issue":"3","key":"2020060307353569900_i2168-9709-9-3-133-b05","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/1455072517706304","article-title":"The slippery slope of flubromazolam: experiences of a novel psychoactive benzodiazepine as discussed on a Swedish online forum","volume":"34","author":"Andersson","year":"2017","journal-title":"Nordic Stud Alcohol Drugs"},{"key":"2020060307353569900_i2168-9709-9-3-133-b06","article-title":"Schedule I, 54.1 Code of Virginia Sect. 3446","year":"2018"},{"issue":"8","key":"2020060307353569900_i2168-9709-9-3-133-b07","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/dta.2146","article-title":"Bjerre Holm N, Stybe Johansen S, Linnet K. 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