{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:34:27Z","timestamp":1778978067976,"version":"3.51.4"},"reference-count":23,"publisher":"American Association of Psychiatric Pharmacists (AAPP)","issue":"1","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D deficiency has been correlated with non-scarring alopecia including alopecia areata or female pattern hair loss. It was theorized that hair loss secondary to vitamin D deficiency in patients susceptible to trichotillomania may exacerbate this obsessive-compulsive disorder. Though vitamin D deficiency is common, especially among patients suffering from neuropsychiatric disorders, its correlation with trichotillomania is not well reported. Two female patients suffering from trichotillomania defined by noticeable hair loss on the scalp through the Massachusetts General Hospital Hair Pulling Scale were treated to promote hair growth. Treatment included dietary supplementation with vitamin D3 1000 IU every day. It was found that in both patients treated with vitamin D3, marked improvements occurred over the span of 3 to 4 months. These included a reduction in obsessive compulsive disorder related hair loss as measured using the Massachusetts General Hospital Hair Pulling Scale, which correlated to their serum 25-hydroxyvitamin D levels. Experimental and clinical evidence is available to explain the underlying physiology and its probable relationship to trichotillomania's pathophysiology.<\/jats:p>","DOI":"10.9740\/mhc.2020.01.038","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T19:48:15Z","timestamp":1578599295000},"page":"38-43","source":"Crossref","is-referenced-by-count":9,"title":["Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report"],"prefix":"10.9740","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4566-9723","authenticated-orcid":false,"given":"Erika","family":"Titus-Lay","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Clinical and Administrative Sciences, College of Pharmacy, California Northstate University, Elk Grove, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8117-949X","authenticated-orcid":false,"given":"Tony Joseph","family":"Eid","sequence":"first","affiliation":[{"name":"Assistant Professor of Clinical and Administrative Sciences, Director of Experiential Education, Pharmacist Clinician, Beale Air Force Base 9th Medical Group, Department of Experiential Education, College of Pharmacy, California Northstate University, Elk Grove, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-0131","authenticated-orcid":false,"given":"Tiffany-Jade","family":"Kreys","sequence":"first","affiliation":[{"name":"Assistant Dean of Student Affairs and Admissions, Assistant Professor, Department of Clinical and Administrative Sciences, College of Pharmacy, California Northstate University, Elk Grove, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-8208","authenticated-orcid":false,"given":"Bo Xuan Joshua","family":"Chu","sequence":"first","affiliation":[{"name":"Student, College of Pharmacy, California Northstate University, Elk Grove, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-5115","authenticated-orcid":false,"given":"Ashim","family":"Malhotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4719","reference":[{"key":"2020060307361032300_i2168-9709-10-1-38-b01","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington (VA): American Psychiatric Publishing;2013.","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"3-4","key":"2020060307361032300_i2168-9709-10-1-38-b02","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1159\/000289004","article-title":"The Massachusetts General Hospital (MGH) hairpulling scale: 2. reliability and validity","volume":"64","author":"O'Sullivan","year":"1995","journal-title":"Psychother Psychosom"},{"issue":"9","key":"2020060307361032300_i2168-9709-10-1-38-b03","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1176\/appi.ajp.2016.15111432","article-title":"Trichotillomania","volume":"173","author":"Grant","year":"2016","journal-title":"Am J Psychiatry"},{"key":"2020060307361032300_i2168-9709-10-1-38-b04","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007662.pub2","article-title":"Pharmacotherapy for trichotillomania","author":"Rothbart","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"5-6","key":"2020060307361032300_i2168-9709-10-1-38-b05","first-page":"21","article-title":"Physician prescribing practices of vitamin d in a psychiatric hospital","volume":"13","author":"Mulcahy","year":"2016","journal-title":"Innov Clin Neurosci"},{"issue":"12","key":"2020060307361032300_i2168-9709-10-1-38-b06","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.3390\/ijms18122653","article-title":"The role of vitamin D in non-scarring alopecia","volume":"18","author":"Gerkowicz","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2020060307361032300_i2168-9709-10-1-38-b07","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/j.1753-4887.2009.00220.x","article-title":"Vitamin D and the occurrence of depression: causal association or circumstantial evidence?","volume":"67","author":"Bertone-Johnson","year":"2009","journal-title":"Nutr Rev"},{"issue":"3","key":"2020060307361032300_i2168-9709-10-1-38-b08","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","article-title":"New clues about vitamin D functions in the nervous system","volume":"13","author":"Garcion","year":"2002","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"2020060307361032300_i2168-9709-10-1-38-b09","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"2020060307361032300_i2168-9709-10-1-38-b10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbr.2004.07.008","article-title":"Behavioural characterization of vitamin D receptor knockout mice","volume":"157","author":"Burne","year":"2005","journal-title":"Behav Brain Res"},{"issue":"3-5","key":"2020060307361032300_i2168-9709-10-1-38-b11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jsbmb.2007.03.032","article-title":"Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice","volume":"104","author":"Minasyan","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2020060307361032300_i2168-9709-10-1-38-b12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1196\/annals.1369.023","article-title":"Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine","volume":"1074","author":"Cass","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"2020060307361032300_i2168-9709-10-1-38-b13","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0006-8993(82)90331-6","article-title":"Chronic vitamin D deficiency in the weanling rat alters catecholamine metabolism in the cortex","volume":"242","author":"Baksi","year":"1982","journal-title":"Brain Res"},{"issue":"2","key":"2020060307361032300_i2168-9709-10-1-38-b14","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1471-4159.2005.03579.x","article-title":"Cross-talk of vitamin D and glucocorticoids in hippocampal cells","volume":"96","author":"Obradovic","year":"2006","journal-title":"J Neurochem"},{"issue":"6","key":"2020060307361032300_i2168-9709-10-1-38-b15","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s00421-012-2582-7","article-title":"Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults","volume":"113","author":"Barker","year":"2013","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"2020060307361032300_i2168-9709-10-1-38-b16","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/s0028-3908(01)00009-0","article-title":"Protective effects of 1\u03b1,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture","volume":"40","author":"Ibi","year":"2001","journal-title":"Neuropharmacology"},{"issue":"1","key":"2020060307361032300_i2168-9709-10-1-38-b17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.5152\/npa.2015.8763","article-title":"Vitamin D deficiency in obsessive\u2013compulsive disorder patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: a case control study","volume":"53","author":"Celik","year":"2016","journal-title":"Arch Neuropsychiatr"},{"key":"2020060307361032300_i2168-9709-10-1-38-b18","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.psychres.2017.04.032","article-title":"Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder","volume":"254","author":"Esnafo\u011flu","year":"2017","journal-title":"Psychiatry Res"},{"issue":"3","key":"2020060307361032300_i2168-9709-10-1-38-b19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/08039488.2017.1406985","article-title":"Vitamin D levels in children and adolescents with obsessive compulsive disorder","volume":"72","author":"Yazici","year":"2018","journal-title":"Nord J Psychiatry"},{"issue":"6","key":"2020060307361032300_i2168-9709-10-1-38-b20","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cpr.2013.05.004","article-title":"Emotion regulation and other psychological models for body-focused repetitive behaviors","volume":"33","author":"Roberts","year":"2013","journal-title":"Clin Psychol Rev"},{"issue":"2","key":"2020060307361032300_i2168-9709-10-1-38-b21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D38S34P6B7","article-title":"Does D matter? The role of vitamin D in hair disorders and hair follicle cycling","volume":"16","author":"Amor","year":"2010","journal-title":"Dermatol Online J"},{"issue":"18","key":"2020060307361032300_i2168-9709-10-1-38-b22","first-page":"5123","article-title":"Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D3","volume":"52","author":"Jimenez","year":"1992","journal-title":"Cancer Res"},{"issue":"8","key":"2020060307361032300_i2168-9709-10-1-38-b23","doi-asserted-by":"publisher","first-page":"615","DOI":"10.5966\/sctm.2012-0032","article-title":"1\u03b1,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration","volume":"1","author":"Aoi","year":"2012","journal-title":"Stem Cells Transl Med"}],"container-title":["Mental Health Clinician"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/mhc\/article-pdf\/10\/1\/38\/2427554\/mhc_2020_01_038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/mhc\/article-pdf\/10\/1\/38\/2427554\/mhc_2020_01_038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T16:21:47Z","timestamp":1731687707000},"score":1,"resource":{"primary":{"URL":"https:\/\/mhc.kglmeridian.com\/view\/journals\/mhcl\/10\/1\/article-p38.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.9740\/mhc.2020.01.038","relation":{},"ISSN":["2168-9709"],"issn-type":[{"value":"2168-9709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}