{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:59:42Z","timestamp":1792144782201,"version":"4.4.0"},"reference-count":17,"publisher":"American Association of Psychiatric Pharmacists (AAPP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Clozapine is the most effective antipsychotic in the management of treatment-resistant schizophrenia; however, its use is challenging due to the risk of severe adverse effects. Despite the risks associated with clozapine, there is no mandatory monitoring in Canada beyond hematologic testing for agranulocytosis surveillance. This study focuses on the development, implementation, and evaluation of a clozapine clinical toolkit (CTK) targeted at optimizing inpatient clozapine use.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A comprehensive literature review was conducted to identify clozapine best practices, experts were consulted, and a comprehensive clozapine CTK was developed and implemented at a large Canadian tertiary hospital in December 2018. To evaluate the CTK, a retrospective chart review was conducted to assess for change in guideline-concordant monitoring pre- and post- CTK implementation. Patients were included if they were >\u200918 years of age and received clozapine during inpatient admission. Results were analyzed using descriptive and inferential statistics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among the charts reviewed, 185 and 113 admissions met the pre- and post-CTK inclusion criteria, respectively. Staff used the CTK in the care of 96% of clozapine patients post implementation, and its use resulted in improvements in guideline-concordant monitoring for agranulocytosis and myocarditis.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Implementation of the clozapine CTK increased the concordance of clozapine monitoring with best practice recommendations. Future research is necessary to assess the impact of the CTK on clinical outcomes and patient satisfaction.<\/jats:p>\n <\/jats:sec>","DOI":"10.9740\/mhc.2024.04.085","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T14:29:19Z","timestamp":1711981759000},"page":"85-91","source":"Crossref","is-referenced-by-count":2,"title":["Clozapine clinical toolkit optimizes inpatient clozapine monitoring"],"prefix":"10.9740","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-0298","authenticated-orcid":true,"given":"Brooke","family":"Gessner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-0473","authenticated-orcid":true,"given":"Michelle","family":"Carter","sequence":"additional","affiliation":[{"name":"Clinical Nurse Specialist, School of Nursing, University of British Columbia, Vancouver, British Columbia, Canada; St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-8836","authenticated-orcid":true,"given":"Kiana","family":"Rahnama","sequence":"additional","affiliation":[{"name":"Clinical Pharmacist, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-4213","authenticated-orcid":true,"given":"Alberto","family":"Almeida","sequence":"additional","affiliation":[{"name":"Project Manager, St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-8544","authenticated-orcid":true,"given":"Colleen","family":"Borralho","sequence":"additional","affiliation":[{"name":"Care Management Leader, Vancouver General Hospital, Vancouver Coastal Health, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-9186","authenticated-orcid":true,"given":"Tamara","family":"Mihic","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; St. Paul\u2019s Hospital, Providence Health, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6396-1886","authenticated-orcid":true,"given":"Joan C. Y.","family":"Ng","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; Vancouver General Hospital, Vancouver Coastal Health, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-5773","authenticated-orcid":true,"given":"Joseph H.","family":"Puyat","sequence":"additional","affiliation":[{"name":"Assistant Professor, Center for Health Evaluation and Outcome Sciences, Providence Health Care, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-1610","authenticated-orcid":true,"given":"Angela","family":"Russolillo","sequence":"additional","affiliation":[{"name":"Clinical Nurse Specialist, Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada; St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-0439","authenticated-orcid":true,"given":"Katelyn C.","family":"Halpape","sequence":"additional","affiliation":[{"name":"Associate Professor, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4719","reference":[{"key":"i2168-9709-14-2-85-b01","series-title":"Bmc Psychiatrybmc Psychiatry","first-page":"102","article-title":"Clozapine: a review of clinical practice guidelines and prescribing trends","volume":"14","author":"Warnez","year":"2014","unstructured":"Warnez\n S,\n \n \n Alessi-Severini\n S.\n \n \n Clozapine: a review of clinical practice guidelines and prescribing trends. Bmc Psychiatrybmc Psychiatry. 2014;14:102. DOI: 10.1186\/1471-244X-14-102"},{"issue":"4","key":"i2168-9709-14-2-85-b02","series-title":"Clin Psychopharmacol Neurosci","first-page":"323","article-title":"Clozapine monitoring in clinical practice: beyond the mandatory requirement","volume":"14","author":"Kar","year":"2016","unstructured":"Kar\n N,\n \n \n Barreto\n S,\n \n \n Chandavarkar\n R.\n \n \n Clozapine monitoring in clinical practice: beyond the mandatory requirement. Clin Psychopharmacol Neurosci. 2016;14(4):323-9. DOI: 10.9758\/cpn.2016.14.4.323"},{"key":"i2168-9709-14-2-85-b03","article-title":"Summary safety review \u2013 clozapine \u2013 assessing the effectiveness of monitoring for low numbers of white blood cells","author":"Government of Canada","year":"2018","unstructured":"Government of Canada\n . 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DOI: 10.1161\/01.CIR.95.1.163"}],"container-title":["Mental Health Clinician"],"original-title":[],"link":[{"URL":"https:\/\/mhc.kglmeridian.com\/view\/journals\/mhcl\/14\/2\/article-p85.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/mhc\/article-pdf\/14\/2\/85\/3366338\/i2168-9709-14-2-85.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/mhc.kglmeridian.com\/downloadpdf\/journals\/mhcl\/14\/2\/article-p85.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/mhc.kglmeridian.com\/downloadpdf\/journals\/mhcl\/14\/2\/article-p85.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:34:14Z","timestamp":1732062854000},"score":1,"resource":{"primary":{"URL":"https:\/\/mhc.kglmeridian.com\/view\/journals\/mhcl\/14\/2\/article-p85.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":17,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.9740\/mhc.2024.04.085","relation":{},"ISSN":["2168-9709"],"issn-type":[{"value":"2168-9709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}