{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:55:52Z","timestamp":1790866552962,"version":"4.1.0"},"reference-count":26,"publisher":"American Association of Psychiatric Pharmacists (AAPP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer is the second leading cause of death in the United States with an incidence rate of approximately 442.3 out of 100\u2009000. In 2021, colorectal cancer (CRC) was responsible for more than 52\u2009000 deaths. Screening is a preventive practice that can detect CRC early. More than 70% of adults aged 45 years or older get screened at least once, yet far fewer follow recommended screening guidelines. Depression is associated with an increased risk of CRC and CRC-related mortality and a reduction in regular CRC screening, making it a significant psychosocial barrier to preventive screening. This cross-sectional study examined factors associated with adherence to CRC screening recommendations, particularly among individuals with a self-reported depression diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing a representative national sample (n = 204 \u2009539) from the 2023 Behavioral Risk Factor Surveillance System (adults aged\u226550), we assessed the effects of depression and key variables associated with depression and CRC screening on the likelihood of adherence. Our model included interactions between depression and race\/ethnicity, education, and income among other variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>African Americans (AA) with depression were 60% less likely to meet recommendations than AA without depression (odds ratio = 0.40, 99% confidence interval = 0.29, 0.55).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results suggest a critical need for health care practitioners to assess patient mental health, especially among AA patients, who are at higher risk of developing CRC despite an overall higher likelihood of being screened. Targeting the highest risk individuals, particularly those with depression, may reduce costs for public health campaigns targeting CRC screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.9740\/mhc.2026.10.229","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:07:51Z","timestamp":1790863671000},"page":"229-234","source":"Crossref","is-referenced-by-count":0,"title":["The role of depression in adherence to colorectal cancer screening guidelines"],"prefix":"10.9740","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4980-7905","authenticated-orcid":true,"given":"Ashley","family":"Becker","sequence":"first","affiliation":[{"name":"(Corresponding author) Student, University of South Carolina, Columbia, South Carolina, abbecker@email.sc.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2612-0468","authenticated-orcid":true,"given":"Samantha","family":"Bjelis","sequence":"additional","affiliation":[{"name":"Student, University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-5165","authenticated-orcid":true,"given":"Daniel","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Professor of Public Health, LaSalle University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4719","reference":[{"key":"i2168-9709-16-5-229-b01","article-title":"United States cancer cases and death statistics at a glance: U.S. Department of Health and Human Services","author":"U.S. Cancer Statistics Working Group. 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Available from: https:\/\/www.cdc.gov\/united-states-cancer-statistics\/dataviz\/index.html"},{"issue":"7","key":"i2168-9709-16-5-229-b03","series-title":"Lancet Oncol","first-page":"1002","article-title":"Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study","volume":"22","author":"Cardoso","year":"2021","unstructured":"Cardoso R,\nGuo F,\nHeisser T,\nHackl M,\nIhle P,\nDe Schutter H, et al. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study. Lancet Oncol. 2021;22(7):1002-13. DOI: 10.1016\/S1470-2045(21)00199-6"},{"issue":"9","key":"i2168-9709-16-5-229-b04","series-title":"J Natl Cancer Inst","first-page":"1177","article-title":"Long-term colorectal cancer incidence and mortality after colonoscopy screening according to individuals\u2019 risk profiles","volume":"113","author":"Wang","year":"2021","unstructured":"Wang K,\nMa W,\nWu K,\nOgino S,\nGiovannucci EL,\nChan AT, et al. Long-term colorectal cancer incidence and mortality after colonoscopy screening according to individuals\u2019 risk profiles. J Natl Cancer Inst. 2021;113(9):1177-85. DOI: 10.1093\/jnci\/djab041"},{"issue":"1","key":"i2168-9709-16-5-229-b05","series-title":"CA Cancer J Clin","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","unstructured":"Siegel RL,\nKratzer TB,\nGiaquinto AN,\nSung H,\nJemal A. Cancer statistics, 2025. CA Cancer J Clin. 2025;75(1):10-45. DOI: 10.3322\/caac.21871"},{"key":"i2168-9709-16-5-229-b06","article-title":"Screening for colorectal cancer: an evidence update for the US Preventive Services Task Force [Internet]. 2021","author":"Lin","unstructured":"Lin JS,\nPerdue LA,\nHenrikson NB,\nBean SI,\nBlasi PR. Screening for colorectal cancer: an evidence update for the US Preventive Services Task Force [Internet]. 2021. [cited 2021 May]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK570913\/"},{"issue":"11","key":"i2168-9709-16-5-229-b07","series-title":"Turk J Gastroenterol","first-page":"901","article-title":"Colorectal cancer screening prevalence, perceived barriers, and preference for screening colonoscopy among hospitalized women","volume":"33","author":"Graham","year":"2022","unstructured":"Graham H,\nKauffman R,\nKhaliq W. Colorectal cancer screening prevalence, perceived barriers, and preference for screening colonoscopy among hospitalized women. Turk J Gastroenterol. 2022;33(11):901-8. DOI: 10.5152\/tjg.2022.21567"},{"key":"i2168-9709-16-5-229-b08","article-title":"Major depression 2021","author":"National Institute of Mental Health. Health NIoM","unstructured":"National Institute of Mental Health. Health NIoM. Major depression 2021 [updated July 2023; cited 2026]. Available from: https:\/\/www.nimh.nih.gov\/health\/statistics\/major-depression"},{"key":"i2168-9709-16-5-229-b09","series-title":"J Affect Disord","first-page":"299","article-title":"Restoring function in major depressive disorder: a systematic review","volume":"215","author":"Sheehan","year":"2017","unstructured":"Sheehan DV,\nNakagome K,\nAsami Y,\nPappadopulos EA,\nBoucher M. Restoring function in major depressive disorder: a systematic review. J Affect Disord. 2017;215:299-313. DOI: 10.1016\/j.jad.2017.02.029"},{"key":"i2168-9709-16-5-229-b10","series-title":"Neuropsychiatr Dis Treat","first-page":"239","article-title":"Functional impairment in patients with major depressive disorder: the 2-year PERFORM study","volume":"14","author":"Hammer-Helmich","year":"2018","unstructured":"Hammer-Helmich L,\nHaro JM,\nJ\u00f6nsson B,\nTanguy Melac A,\nDi Nicola S,\nChollet J, et al. Functional impairment in patients with major depressive disorder: the 2-year PERFORM study. Neuropsychiatr Dis Treat. 2018;14:239-49. DOI: 10.2147\/NDT.S146098"},{"key":"i2168-9709-16-5-229-b11","series-title":"J Affect Disord","first-page":"1234","article-title":"Estimating the global treatment rates for depression: a systematic review and meta-analysis","volume":"295","author":"Mekonen","year":"2021","unstructured":"Mekonen T,\nChan GCK,\nConnor JP,\nHides L,\nLeung J. Estimating the global treatment rates for depression: a systematic review and meta-analysis. J Affect Disord. 2021;295:1234-42. DOI: 10.1016\/j.jad.2021.09.038"},{"issue":"3","key":"i2168-9709-16-5-229-b12","series-title":"World Psychiatry","first-page":"366","article-title":"Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management","volume":"22","author":"Berk","year":"2023","unstructured":"Berk M,\nK\u00f6hler-Forsberg O,\nTurner M,\nPenninx BWJH,\nWrobel A,\nFirth J, et al. Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management. World Psychiatry. 2023;22(3):366-87. 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Available from: https:\/\/www.cdc.gov\/brfss\/annual_data\/annual_2023.html"},{"issue":"19","key":"i2168-9709-16-5-229-b15","series-title":"JAMA","first-page":"1965","article-title":"Screening for colorectal cancer: US Preventive Services Task Force recommendation statement","volume":"325","author":"Davidson","year":"2021","unstructured":"Davidson KW,\nBarry MJ,\nMangione CM,\nCabana M,\nCaughey AB,\nDavis EM, et al. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA. 2021;325(19):1965-77. DOI: 10.1001\/jama.2021.6238"},{"issue":"1","key":"i2168-9709-16-5-229-b16","series-title":"Gastroenterology","first-page":"285","article-title":"Updates on age to start and stop colorectal cancer screening: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer","volume":"162","author":"Patel","year":"2022","unstructured":"Patel SG,\nMay FP,\nAnderson JC,\nBurke CA,\nDominitz JA,\nGross SA, et al. 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DOI: 10.1002\/9781118548387"},{"issue":"1","key":"i2168-9709-16-5-229-b19","series-title":"BMC Public Health","first-page":"1280","article-title":"Decreased colorectal cancer incidence and mortality in a diverse urban population with increased colonoscopy screening","volume":"21","author":"Brown","year":"2021","unstructured":"Brown JJ,\nAsumeng CK,\nGreenwald D,\nWeissman M,\nZauber A,\nStriplin J, et al. Decreased colorectal cancer incidence and mortality in a diverse urban population with increased colonoscopy screening. BMC Public Health. 2021;21(1):1280. DOI: 10.1186\/s12889-021-11330-6"},{"issue":"2","key":"i2168-9709-16-5-229-b20","series-title":"Am J Pathol","first-page":"291","article-title":"Colorectal cancer disparity in African Americans: risk factors and carcinogenic mechanisms","volume":"188","author":"Augustus","year":"2018","unstructured":"Augustus GJ,\nEllis NA. Colorectal cancer disparity in African Americans: risk factors and carcinogenic mechanisms. 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DOI: 10.1080\/10410236.2021.1901422"},{"issue":"5","key":"i2168-9709-16-5-229-b24","series-title":"Am J Psychiatry","first-page":"365","article-title":"The critical relationship between anxiety and depression","volume":"177","author":"Kalin","year":"2020","unstructured":"Kalin NH. The critical relationship between anxiety and depression. Am J Psychiatry. 2020;177(5):365-7. DOI: 10.1176\/appi.ajp.2020.20030305"},{"key":"i2168-9709-16-5-229-b25","series-title":"Epidemiologic Approach to Evaluating Screening Programs","first-page":"360","article-title":"Godis Epidemiology","author":"Celentano","year":"2018","unstructured":"Celentano DD,\nSzklo M, editors. Godis Epidemiology. 6th ed. Epidemiologic Approach to Evaluating Screening Programs, Elsevier; 2018. p. 360-3. 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