{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:15:38Z","timestamp":1792800938642,"version":"4.5.0"},"reference-count":21,"publisher":"American Association of Psychiatric Pharmacists (AAPP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypothermia is a rare, potentially life-threatening adverse effect of antipsychotics, including risperidone. Defined as a core temperature&lt;35\u00b0C (95\u00b0F), it can occur even at therapeutic doses and may be underrecognized, particularly in older adults or medically complex patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An 84-year-old woman with a history of psychosis and comorbidities developed severe hypothermia (31.9\u00b0C\/87.8\u00b0F) 20 days after switching from quetiapine to risperidone. Infection, endocrine abnormalities, and environmental causes were excluded. Risperidone was discontinued, and normothermia was restored within 3 days. Notably, a month prior, she had a hypothermic episode while on quetiapine in the setting of infection and prescribed opioid use despite tolerating it for 5 years. Aripiprazole was later initiated and titrated to 15 mg daily; her temperature intermittently approached 35\u00b0C\/95\u00b0F without symptoms but remained stable over 4 years of follow-up without further hypothermic episodes despite experiencing infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This case highlights diagnostic challenges and the potential for antipsychotic-induced hypothermia to recur across different agents in the same patient. Literature review suggests the phenomenon is more common than previously believed, particularly among older patients. Whereas risperidone and quetiapine are implicated in multiple reports, aripiprazole may be better tolerated in some predisposed individuals. Routine temperature monitoring during antipsychotic initiation and titration is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Risperidone can cause severe hypothermia in older patients even at standard doses. Clinicians should consider alternative antipsychotics when hypothermia occurs and consider that it can recur even if confounding factors are resolved. This case supports the inclusion of temperature surveillance in antipsychotic treatment protocols for older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.9740\/mhc.2026.10.235","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:09:14Z","timestamp":1790863754000},"page":"235-239","source":"Crossref","is-referenced-by-count":1,"title":["Risperidone-induced severe hypothermia in an elderly woman with possible prior quetiapine-associated hypothermia tolerating aripiprazole: A case report and literature review"],"prefix":"10.9740","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6932-0983","authenticated-orcid":true,"given":"Audrey","family":"Seguin","sequence":"first","affiliation":[{"name":"Assistant Chief Pharmacist, Pierre-Le Gardeur Hospital, Terrebonne, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5162-7372","authenticated-orcid":true,"given":"Nika","family":"Niknam","sequence":"additional","affiliation":[{"name":"Psychiatrist, Clinical, Assistant, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1959-2076","authenticated-orcid":true,"given":"Arash","family":"Bahremand","sequence":"additional","affiliation":[{"name":"Associate Researcher, Research Centre, Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al, Montreal, Qu\u00e9bec, Canada; Psychiatrist and Assistant Professor, Department of Psychiatry and Addictology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-224X","authenticated-orcid":true,"given":"Violaine","family":"Masson","sequence":"additional","affiliation":[{"name":"(Corresponding author) Clinical Pharmacist, Pharmacy Department, Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada; Lecturer, Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada, violaine.masson.1@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4719","reference":[{"issue":"5","key":"i2168-9709-16-5-235-b01","series-title":"Cureus","first-page":"e24836","article-title":"A rare case of risperidone-induced hypothermia and thrombocytopenia","volume":"14","author":"Goyal","year":"2022","unstructured":"Goyal L,\nAcebo R,\nIslam S,\nAjmera K,\nKaasam S. A rare case of risperidone-induced hypothermia and thrombocytopenia. Cureus. 2022;14(5):e24836. DOI: 10.7759\/cureus.24836"},{"issue":"2","key":"i2168-9709-16-5-235-b02","series-title":"Ther Adv Psychopharmacol","first-page":"70","article-title":"De novo delayed onset hypothermia secondary to therapeutic doses of risperidone in bipolar affective disorder","volume":"4","author":"Perera","year":"2014","unstructured":"Perera MA,\nYogaratnam J. De novo delayed onset hypothermia secondary to therapeutic doses of risperidone in bipolar affective disorder. Ther Adv Psychopharmacol. 2014;4(2):70-4. DOI: 10.1177\/2045125313507740"},{"key":"i2168-9709-16-5-235-b03","series-title":"Front Psychiatry","first-page":"165","article-title":"Hypothermia due to antipsychotic medication: a systematic review","volume":"8","author":"Zonnenberg","year":"2017","unstructured":"Zonnenberg C,\nBueno-de-Mesquita JM,\nRamlal D,\nBlom JD. Hypothermia due to antipsychotic medication: a systematic review. Front Psychiatry. 2017;8:165. DOI: 10.3389\/fpsyt.2017.00165"},{"key":"i2168-9709-16-5-235-b04","series-title":"J Acad Consult Liaison Psychiatry","article-title":"Recurrent hypothermia after risperidone therapy in an elderly patient with Alzheimer\u2019s dementia and psychotic features","author":"Vyas","year":"2024","unstructured":"Vyas S,\nGarg S. Recurrent hypothermia after risperidone therapy in an elderly patient with Alzheimer\u2019s dementia and psychotic features. J Acad Consult Liaison Psychiatry. 2024. DOI: 10.1016\/j.jaclp.2024.11.002"},{"issue":"4","key":"i2168-9709-16-5-235-b05","series-title":"Z Kinder Jugendpsychiatr Psychother","first-page":"335","article-title":"Mild hypothermia in a child with low-dose risperidone","volume":"45","author":"Grau","year":"2017","unstructured":"Grau K,\nPlener PL,\nGahr M,\nDenzer C,\nFreudenmann RW. Mild hypothermia in a child with low-dose risperidone. Z Kinder Jugendpsychiatr Psychother. 2017;45(4):335-7. 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