{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:40:26Z","timestamp":1772271626079,"version":"3.50.1"},"reference-count":56,"publisher":"Korean College of Neuropsychopharmacology","issue":"1","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSC101-2314-B- 006-063-MY3"],"award-info":[{"award-number":["NSC101-2314-B- 006-063-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["DOH 98-TD-I-111-DD004"],"award-info":[{"award-number":["DOH 98-TD-I-111-DD004"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["07A1-NPPP08-021"],"award-info":[{"award-number":["07A1-NPPP08-021"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.cpn.or.kr"],"crossmark-restriction":true},"short-container-title":["Clin Psychopharmacol Neurosci"],"published-print":{"date-parts":[[2020,2,29]]},"DOI":"10.9758\/cpn.2020.18.1.136","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T21:50:23Z","timestamp":1579557023000},"page":"136-144","update-policy":"https:\/\/doi.org\/10.9758\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>ALDH2<\/i>\n                    Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment"],"prefix":"10.9758","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-3742","authenticated-orcid":false,"given":"Po-Wei","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-9967","authenticated-orcid":false,"given":"Tzu-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-2457","authenticated-orcid":false,"given":"Yun-Hsuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Department of Psychology, Asia University, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-9643","authenticated-orcid":false,"given":"Sheng-Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Department of Psychiatry, Kaohsiung Veterans General Hospital, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-0276","authenticated-orcid":false,"given":"Shiou-Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Graduate Institute of Medicine, College of Medicine, Taiwan"},{"name":"Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-8691","authenticated-orcid":false,"given":"Ze-Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang,"},{"name":"Beijing YiNing Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-578X","authenticated-orcid":false,"given":"Po See","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Addiction Research Center, National Cheng Kung University,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-2584","authenticated-orcid":false,"given":"Chun-Hsien","family":"Chu","sequence":"additional","affiliation":[{"name":"0Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-238X","authenticated-orcid":false,"given":"San-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-7089","authenticated-orcid":false,"given":"Nian-Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center"},{"name":"Student Counseling Center, National Defense Medical Center, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-5744","authenticated-orcid":false,"given":"I Hui","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Addiction Research Center, National Cheng Kung University,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-8820","authenticated-orcid":false,"given":"Kao Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Addiction Research Center, National Cheng Kung University,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9636","authenticated-orcid":false,"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"Addiction Research Center, National Cheng Kung University,"},{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-8401","authenticated-orcid":false,"given":"Jau-Shyong","family":"Hong","sequence":"additional","affiliation":[{"name":"Neurobiology Laboratory, NIH\/NIEHS, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-3547","authenticated-orcid":false,"family":"Ru-BLu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan,"},{"name":"The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang,"},{"name":"Beijing YiNing Hospital, Beijing, China"},{"name":"Addiction Research Center, National Cheng Kung University,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4713","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12551"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-007-9034-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00169"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2016.03.018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.06.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.07.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.10.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/00207450109149753"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960920)67:5<473::AID-AJMG6>3.0.CO;2-L"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.06.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2003327"},{"key":"ref13","unstructured":"Stewart MJ, Malek K, Crabb DW. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 1996;44:42-46."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.6379"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000117832.62901.61"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.12.011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0117-y"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15048740"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.10.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hup.755"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.022"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.14.2.157"},{"key":"ref23","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental. 4th ed. Washington: American Psychiatric Association; 1994."},{"key":"ref24","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59 Suppl 20:22-33."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.2.147"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.54.2.249"},{"key":"ref28","unstructured":"Lung FW, Cheng CT, Chang WT, Shu BC. Anxiety and mood disorder in young males with mitral valve prolapse. J Multidiscip Healthc 2008;1:89-92."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.1995.0030"},{"key":"ref30","unstructured":"Conners CK, Staff M. Conners\u2019 Continuous Performance Test II (CPT II): computer program for windows, technical guide and software manual. New york: Multi-Health Systems; 2000."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/srep09708"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01353.x"},{"key":"ref33","unstructured":"Wechsler D. Wechsler memory scale--revised: manual. San Antonio: The Psychological Corporation; 1987."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1080\/09084282.2012.689267"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/BF01109053"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1994.tb01114.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.4.1247"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2012.01758.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1086\/302540"},{"key":"ref41","unstructured":"Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991;48:677-681."},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7141-9_3"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90020-4"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02309-X"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.7.686"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.09.016"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb00713.x"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100011938"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.020"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.02.025"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3182900fb3"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/act072"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000050"},{"key":"ref54","unstructured":"Chen CH, Joshi AU, Mochly-Rosen D. The role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in neuropathology and neurodegeneration. Acta Neurol Taiwan 2016;25:111-123."},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2009.00157.x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111\/add.13238"}],"container-title":["Clinical Psychopharmacology and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/CPN2\/2020\/018\/cpn018-01-15.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"http:\/\/pdf.medrang.co.kr\/CPN2\/2020\/018\/cpn018-01-15.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T03:27:17Z","timestamp":1580441237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cpn.or.kr\/journal\/view.html?doi=10.9758\/cpn.2020.18.1.136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2,29]]}},"alternative-id":["10.9758\/cpn.2020.18.1.136"],"URL":"https:\/\/doi.org\/10.9758\/cpn.2020.18.1.136","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737246087.793570362","asserted-by":"object"}]},"ISSN":["1738-1088","2093-4327"],"issn-type":[{"value":"1738-1088","type":"print"},{"value":"2093-4327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,29]]},"assertion":[{"value":"http:\/\/www.cpn.or.kr\/journal\/view.html?doi=10.9758\/cpn.2020.18.1.136","URL":"http:\/\/www.cpn.or.kr\/journal\/view.html?doi=10.9758\/cpn.2020.18.1.136","name":"the_journal","label":"Clinical Psychopharmacology and Neuroscience","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2019-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"https:\/\/orcid.org\/0000-0001-7401-3742","URL":"https:\/\/orcid.org\/0000-0001-7401-3742","name":"author","label":"Po-Wei Lee","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0002-0561-9967","URL":"https:\/\/orcid.org\/0000-0002-0561-9967","name":"author","label":"Tzu-Yun Wang","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-8662-2457","URL":"https:\/\/orcid.org\/0000-0001-8662-2457","name":"author","label":"Yun-Hsuan Chang","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-7796-9643","URL":"https:\/\/orcid.org\/0000-0001-7796-9643","name":"author","label":"Sheng-Yu Lee","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-3995-0276","URL":"https:\/\/orcid.org\/0000-0003-3995-0276","name":"author","label":"Shiou-Lan Chen","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-2339-8691","URL":"https:\/\/orcid.org\/0000-0003-2339-8691","name":"author","label":"Ze-Cheng Wang","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-4963-578X","URL":"https:\/\/orcid.org\/0000-0003-4963-578X","name":"author","label":"Po See Chen","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-2934-2584","URL":"https:\/\/orcid.org\/0000-0003-2934-2584","name":"author","label":"Chun-Hsien Chu","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-1268-238X","URL":"https:\/\/orcid.org\/0000-0003-1268-238X","name":"author","label":"San-Yuan Huang","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-5881-7089","URL":"https:\/\/orcid.org\/0000-0001-5881-7089","name":"author","label":"Nian-Sheng Tzeng","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0003-2970-5744","URL":"https:\/\/orcid.org\/0000-0003-2970-5744","name":"author","label":"I Hui Lee","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-8091-8820","URL":"https:\/\/orcid.org\/0000-0001-8091-8820","name":"author","label":"Kao Chin Chen","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-9355-9636","URL":"https:\/\/orcid.org\/0000-0001-9355-9636","name":"author","label":"Yen Kuang Yang","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0002-3056-8401","URL":"https:\/\/orcid.org\/0000-0002-3056-8401","name":"author","label":"Jau-Shyong Hong","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0001-6411-3547","URL":"https:\/\/orcid.org\/0000-0001-6411-3547","name":"author","label":"Ru-BLu","group":{"name":"orcid","label":"ORCID"}},{"value":"\u00a9 2020 The Korean College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}