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Grounded in efficient coding, Bayesian and predictive frameworks, recurrent and attractor dynamics, neural state-space models, and systems neuroscience, the Principle of Representation Integration for Stable Models (PRISM) proposes five operations: extraction, compression, integration, stabilization, and prediction\/action. Here we developed PRISM-M, a minimal nine-equation recurrent dynamical realization with an explicit contraction condition (0 <\n J<\/jats:italic>\n < 1), to examine whether these operations can generate persistent, context-sensitive, and prospectively informative model states. Seven simulation analyses showed persistent but revisable trajectories and a 0.209 context-dependent shift in the event-period model state. A 60 \u00d7 60 parameter sweep identified 719 rigid, 2,344 adaptive, and 537 high-gain trajectories within this structurally contractive parameter space, and the same regimes were recovered across 1,000 randomized environments. Perturbations of extraction, integration, and stabilization altered model trajectories, whereas the scalar compression perturbation had a small effect. The full PRISM state predicted the next model state more accurately than the model-state-only baseline (RMSE 0.0186 versus 0.0218), while performing similarly to an unconstrained ARX model. In the BART dataset, spatial fMRI states were distinguishable in 155 participants (69.7% accuracy; 33.3% chance), and inflation-related activity was modestly associated with pumping behavior in the 99 participants with matched behavioral data (\n \u03b2<\/jats:italic>\n = 0.198,\n P<\/jats:italic>\n = 0.040). PRISM-M provides a constrained, testable framework centered on four operational signatures of model-like organization structured representation, contextual integration, persistence or reconstructability, and prospective relevance.\n <\/jats:p>\n \n Author Summary<\/jats:title>\n The brain continually receives information from the outside world, the body, and its own ongoing activity, yet useful behavior requires more than simply detecting these signals. Neural information must be selected, organized, combined with context, maintained over time, and used to guide what happens next. We developed PRISM-M, a simple recurrent mathematical implementation of the Principle of Representation Integration for Stable Models (PRISM), to examine how these steps may work together within an explicit model. PRISM-M treats extraction, compression, integration, stabilization, and prediction\/action as five interacting operations and tests whether they can produce internal states that persist over time while remaining able to change. Across seven simulations, the model generated context-sensitive and revisable states, remained mathematically stable across broad parameter ranges, and showed predictable effects when individual operations were altered. We also examined an independent human fMRI dataset from a sequential risk-taking task. The available data supported structured, condition-sensitive neural patterns and a modest relationship with behavior. They also indicated that temporally resolved recordings will be needed to test the full recurrent model directly. Together, these results provide a quantitative and testable framework for studying how neural representations may become stable internal neural models.<\/jats:p>\n <\/jats:sec>","DOI":"10.64898\/2026.09.02.748818","type":"posted-content","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:55:18Z","timestamp":1789088118000},"source":"Crossref","is-referenced-by-count":0,"title":["PRISM-M: A Recurrent Framework for the Formation of Stable Internal Neural Models"],"prefix":"10.64898","author":[{"given":"Eliezer","family":"Masliah","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092707460819000_2026.09.02.748818v1.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1011037"},{"key":"2026092707460819000_2026.09.02.748818v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-023-01584-y"},{"key":"2026092707460819000_2026.09.02.748818v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02087-x"},{"key":"2026092707460819000_2026.09.02.748818v1.4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"2026092707460819000_2026.09.02.748818v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.006"},{"key":"2026092707460819000_2026.09.02.748818v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69068-x"},{"key":"2026092707460819000_2026.09.02.748818v1.7","unstructured":"Tishby N , Pereira FC , Bialek W . he Information Bottleneck Method. 37th Annual Allerton Conference on Communication, Control, and Computing 1999. p. 368\u201377."},{"key":"2026092707460819000_2026.09.02.748818v1.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506855112"},{"key":"2026092707460819000_2026.09.02.748818v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/4580"},{"key":"2026092707460819000_2026.09.02.748818v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nn1790"},{"key":"2026092707460819000_2026.09.02.748818v1.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569931"},{"key":"2026092707460819000_2026.09.02.748818v1.12","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00912"},{"key":"2026092707460819000_2026.09.02.748818v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0919-7"},{"key":"2026092707460819000_2026.09.02.748818v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69041-8"},{"key":"2026092707460819000_2026.09.02.748818v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51582-5"},{"key":"2026092707460819000_2026.09.02.748818v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-026-02231-1"},{"key":"2026092707460819000_2026.09.02.748818v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01731-2"},{"key":"2026092707460819000_2026.09.02.748818v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01845-7"},{"key":"2026092707460819000_2026.09.02.748818v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604187103"},{"key":"2026092707460819000_2026.09.02.748818v1.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"2026092707460819000_2026.09.02.748818v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3470"},{"key":"2026092707460819000_2026.09.02.748818v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08548-w"},{"key":"2026092707460819000_2026.09.02.748818v1.23","doi-asserted-by":"publisher","DOI":"10.1115\/1.3662552"},{"key":"2026092707460819000_2026.09.02.748818v1.24","unstructured":"Ljung L . 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Despite considerable advances in recent years in elucidating its pathogenesis and developing novel immunotherapeutic approaches, the overall survival rate for patients with this central nervous system (CNS) neoplasm remains dismally low. Consequently, there is an urgent and unmet need to identify and characterize additional therapeutic targets that could be employed synergistically with existing treatment modalities to enhance both survival outcomes and quality of life. Among the emerging areas of investigation, substantial interest has been directed toward aging-associated molecular signaling mechanisms that also constitute key oncogenic pathways in GBM. These include aberrant growth factor signaling, hyperactivation of the PI3K\/AKT\/mTOR axis, and inactivation of critical tumor suppressor pathways such as p53 and retinoblastoma (RB). The dysregulation of these signaling cascades results in profound disturbances of essential cellular homeostatic processes, notably autophagy and cellular senescence, which are intimately involved in both tumor initiation and progression. This review aims to delineate the complex interplay between autophagy and cellular senescence within the context of aging-related GBM pathogenesis. 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Malahayati Bandar Lampung","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mal Nurse J."],"abstract":"ABSTRAKLatar Belakang : Hasil Riskesdas tahun 2018 Prevalensi penyakit stroke di Indonesia meningkat seiring bertambahnya umur, kasus stroke tertinggi yang terdiagnosis pada kelompok usia 75 tahun keatas (50,2%) dan terendah pada kelompok usia 15-24 tahun yaitu sebesar (0,6%). Pada penderita stroke post serangan membutuhkan waktu lama untuk memulihkan salah satu nya dengan latihan mobilisasi bagian dari proses rehabilitasi yaitu latihan Range Of Motion (ROM). Tujuan : Literature Review ini bertujuan untuk mengetahui pengaruh Range Of Motion terhadap kekuatan otot pasien stroke. Metode : Penelitian kualitatif dengan pendekatan Literature review menganalisis jurnal penelitian yang berkaitan dengan topic analisis dan metode pencarian menggunakan jurnal intervensi yang dapat diakses full text, tahun jurnal yang digunakan tahun 2011-2021. Hasil : Berdasarkan hasil Literature Review pada 5 jurnal ini menyatakan bahwa Range Of Motion (ROM) sangat berpengaruh\u00a0 pada pasien stroke. Kesimpulan : Hal ini membuktikan bahwa Range Of Motion (ROM) berpengaruh dalam meningkatkan kekuatan otot pada pasien stroke.Kata Kunci : Range Of Motion, Kekuatan otot, StrokeABSTRACT Background: The results of riskesdas in 2018 the prevalence of stroke in indoneisa increases with age, the highest stroke cases diagnosed are those aged 75 years and over (50,2%) and the lowest is in the 15-24 years age group, namely (0,6%). Post attack stroke patients take a long time to recover one of them with mobilization training as part of the rehabilitation process, namely exercise Range Of Motion (ROM). Purpose: This literature review aims to determine the effect of range of motion on muscle strength in stroke patients. Methods: Qualitative research with a literature review approach analyzes research journals related to the topic of analysis and search methods using intervention journals that can be accessed in full text, the journal year used is 2011-2021. Results: Based on the results of the Literature Review in 5 journals, it is stated that Range of Motion (ROM) is very influential in stroke patients. 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Programmer efficacement ces architectures en fonction des applications requiert un effort pluridisciplinaire portant sur les langages d\u00e9di\u00e9s (Domain Specific Languages - DSL), les techniques de g\u00e9n\u00e9ration de code et d'optimisation, et les algorithmes num\u00e9riques propres aux applications. Dans cette th\u00e8se, nous pr\u00e9sentons une m\u00e9thode de programmation haut niveau prenant en compte les caract\u00e9ristiques des architectures h\u00e9t\u00e9rog\u00e8nes et les propri\u00e9t\u00e9s existantes des matrices pour produire un solveur g\u00e9n\u00e9rique d'alg\u00e8bre lin\u00e9aire dense. Notre mod\u00e8le de programmation supporte les transferts explicites et implicites entre un processeur (CPU) et un processeur graphique qui peut \u00eatre g\u00e9n\u00e9raliste (GPU) ou int\u00e9gr\u00e9 (IGP). Dans la mesure o\u00f9 les GPU sont devenus un outil important pour le calcul haute performance, il est essentiel d'int\u00e9grer leur usage dans les plateformes de calcul. Une architecture r\u00e9cente telle que l'IGP requiert des connaissances suppl\u00e9mentaires pour pouvoir \u00eatre programm\u00e9e efficacement. Notre m\u00e9thodologie a pour but de simplifier le d\u00e9veloppement sur ces architectures parall\u00e8les en utilisant des outils de programmation haut niveau. \u00c0 titre d'exemple, nous avons d\u00e9velopp\u00e9 un solveur de moindres carr\u00e9s en pr\u00e9cision mixte bas\u00e9 sur les \u00e9quations semi-normales qui n'existait pas dans les biblioth\u00e8ques actuelles. Nous avons par la suite \u00e9tendu nos travaux \u00e0 un mod\u00e8le de programmation multi-\u00e9tape (\"multi-stage\") pour r\u00e9soudre les probl\u00e8mes d'interop\u00e9rabilit\u00e9 entre les mod\u00e8les de programmation CPU et GPU. Nous utilisons cette technique pour g\u00e9n\u00e9rer automatiquement du code pour acc\u00e9l\u00e9rateur \u00e0 partir d'un code effectuant des op\u00e9rations point par point ou utilisant des squelettes algorithmiques. L'approche multi-\u00e9tape nous assure que le typage du code g\u00e9n\u00e9r\u00e9 est valide. Nous avons ensuite montr\u00e9 que notre m\u00e9thode est applicable \u00e0 d'autres architectures et algorithmes. Les routines d\u00e9velopp\u00e9es ont \u00e9t\u00e9 int\u00e9gr\u00e9es dans une biblioth\u00e8que de calcul appel\u00e9e NT2.Enfin, nous montrons comment la programmation haut niveau peut \u00eatre appliqu\u00e9e \u00e0 des calculs group\u00e9s et des contractions de tenseurs. Tout d'abord, nous expliquons comment concevoir un mod\u00e8le de container en utilisant des techniques de programmation bas\u00e9es sur le C++ moderne (C++-14). Ensuite, nous avons impl\u00e9ment\u00e9 un produit de matrices optimis\u00e9 pour des matrices de petites tailles en utilisant des instructions SIMD. Pour ce faire, nous avons pris en compte les multiples probl\u00e8mes li\u00e9s au calcul group\u00e9 ainsi que les probl\u00e8mes de localit\u00e9 m\u00e9moire et de vectorisation. En combinant la programmation haut niveau avec des techniques avanc\u00e9es de programmation parall\u00e8le, nous montrons qu'il est possible d'obtenir de meilleures performances que celles des biblioth\u00e8ques num\u00e9riques actuelles.<\/jats:p>","DOI":"10.70675\/adc1ba8cz9277z416dza4efz1f75d252c8fd","type":"dissertation","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:37:06Z","timestamp":1775075826000},"approved":{"date-parts":[[2016,9,26]]},"source":"Crossref","is-referenced-by-count":0,"title":["Automatic code generation methods applied to numerical linear algebra in high performance computing"],"prefix":"10.70675","author":[{"given":"Ian","family":"Masliah","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjwb503","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Paris-Saclay (ComUE)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51494","reference":[{"key":"77605_105_9","doi-asserted-by":"crossref","unstructured":"Kolda T. 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Enfin, la mise en perspective de ces changements m\u00e9taboliques avec les alt\u00e9rations \u00e9pig\u00e9n\u00e9tiques observ\u00e9es dans les tumeurs SWI\/SNF d\u00e9ficientes pourrait se r\u00e9v\u00e9ler pertinente pour continuer d\u2019approfondir nos connaissances sur ces tumeurs.<\/jats:p>","DOI":"10.70675\/6fbcda99z3876z41c1z8f67z76fd284aa840","type":"dissertation","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:04:49Z","timestamp":1775163889000},"approved":{"date-parts":[[2018,5,31]]},"source":"Crossref","is-referenced-by-count":0,"title":["Complexe SWI\/SNF et cancer _ Alt\u00e9rations g\u00e9n\u00e9tiques et anomalies m\u00e9taboliques"],"prefix":"10.70675","author":[{"given":"Julien","family":"Masliah-Planchon","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03xjwb503","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Paris-Saclay (ComUE)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51494","reference":[{"key":"101949_92_15","doi-asserted-by":"crossref","unstructured":"Liu J., Guo S., Li Q., Yang L., Xia Z., Zhang L., Huang Z., Zhang N., Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1., in: J. 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Previous studies have shown that cognitive alterations in these disorders are associated with synaptic loss. Injury and loss of synapses might be associated with altered function of synaptic proteins. Among them, recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, such as \u03b1\u2010synuclein, might be associated with plaque formation in AD and Lewy body formation in LBD. Further reinforcing the hypothesis that \u03b1\u2010synuclein plays a major role in the pathogenesis of these disorders, recent work has shown that mutations that alter the conformation of this molecule are associated with familial forms of Parkinson's disease. The mechanisms by which altered function or aggregation of \u03b1\u2010synuclein might lead to neurodegeneration are not completely clear; however, new evidence points to a potential role for this molecule in synaptic damage and neurotoxicity via amyloid\u2010like fibril formation and mitochondrial dysfunction. 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All rights reserved.","name":"copyright","label":"Copyright"}]},{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:07:17Z","timestamp":1782976037056,"version":"3.54.5"},"reference-count":2,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. 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Res."}],"container-title":["Frontiers in Aging Neuroscience"],"deposited":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T19:35:53Z","timestamp":1424288153000},"score":14.749847,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnagi.2014.00114\/abstract"}},"issued":{"date-parts":[[2014,6,10]]},"references-count":2,"URL":"https:\/\/doi.org\/10.3389\/fnagi.2014.00114","ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"published":{"date-parts":[[2014,6,10]]}},{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:57:17Z","timestamp":1777395437861,"version":"3.51.4"},"reference-count":155,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,2,6]]},"abstract":"\u00a0It has been a year since we lost Dale Schenk on September 30, 2016. Dale\u2019s visionary work resulted in the remarkable discovery in 1999 that an experimental amyloid-\u03b2 (A\u03b2) vaccine reduced the neurodegeneration in a transgenic model of Alzheimer\u2019s disease (AD). Following Dale\u2019s seminal work, several active and passive immunotherapies have since been developed and tested in the clinic for AD, Parkinson\u2019s disease (PD), and other neurodegenerative disorders. Here we provide a brief overview of the current state of development of immunotherapy for AD, PD, and other neurodegenerative disorders in the context of this anniversary. 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