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The emphasis is on Kashan city as symbol of the Karizian civilization in central of Iran, which is now facing problems in both quality and quantity of water. Carried out as a library and documentary research, we reviewed the status of Kashan's and Iran's water resources, and identified four major reasons for the present water crisis on a local and national wide scale: (a) lack of land use spatial planning; (b) mismanagement, thirst for development, and self\u2010sufficiency: (c) political decisions on water allocation; and (d) lack of proper water pricing and inability of farmers to optimize irrigation systems. As a consequence, the country is challenged with severe water problems at both local and nation\u2010wide scale, including increasing water demand and scarcity, decreasing groundwater table, deteriorating water quality, and increasing loss of ecosystems. If integrated water resources management plan is not immediately implemented to solve this problem, it is possible that the condition will be more disastrous in the coming years. 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All rights reserved.","name":"copyright","label":"Copyright"}]},{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:34:39Z","timestamp":1754163279467,"version":"3.41.2"},"posted":{"date-parts":[[2025,7,29]]},"group-title":"Engineering","reference-count":0,"publisher":"MDPI AG","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"accepted":{"date-parts":[[2025,7,28]]},"abstract":"<jats:p>This paper investigates the Heterogeneous Electric Vehicle Routing Problem with Time Windows and Energy Minimization, a critical challenge in sustainable urban logistics. We propose a Mixed-Integer Linear Programming model that explicitly minimizes the total energy consumption of a heterogeneous electric vehicle (EV) fleet while satisfying customer demands within specific time windows. The model accounts for vehicle diversity in terms of battery capacities, consumption rates, and charging characteristics, and incorporates distance- and load-based energy consumption under a full-recharge policy. Computational experiments are conducted on a comprehensive set of benchmark-based instances. Results demonstrate the model\u2019s ability to find optimal or near-optimal solutions for small-scale problems, with acceptable optimality gaps for larger instances. Sensitivity analyses reveal the influence of key parameters\u2014battery capacity ratios, consumption rates, recharging speeds, maximum number of active EVs, and payload sensitivity\u2014on energy usage and fleet configuration. Notably, increasing battery capacity or fleet size significantly reduces energy consumption up to a saturation point, while inefficient or slow-charging vehicles negatively affect performance. The findings have direct implications for logistics operators seeking to enhance energy efficiency and environmental performance in EV-based delivery systems.<\/jats:p>","DOI":"10.20944\/preprints202507.2456.v1","type":"posted-content","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:18:19Z","timestamp":1753921099000},"source":"Crossref","is-referenced-by-count":0,"title":["Energy-Aware Routing for Heterogeneous Electric Vehicle Fleets"],"prefix":"10.20944","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-869X","authenticated-orcid":false,"given":"Nima","family":"Moradi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar","family":"Mirzavand Boroujeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Jamalzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Mirzavand Boroujeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:19:04Z","timestamp":1753921144000},"score":17.038326,"resource":{"primary":{"URL":"https:\/\/www.preprints.org\/manuscript\/202507.2456\/v1"}},"issued":{"date-parts":[[2025,7,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.20944\/preprints202507.2456.v1","published":{"date-parts":[[2025,7,29]]},"subtype":"preprint"},{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:04:11Z","timestamp":1648739051889},"reference-count":0,"publisher":"Mathematical Notes","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MMN"],"published-print":{"date-parts":[[2015]]},"DOI":"10.18514\/mmn.2015.1369","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T13:50:51Z","timestamp":1542289851000},"page":"205","source":"Crossref","is-referenced-by-count":0,"title":["Simple proofs of some theorems in resultant theory"],"prefix":"10.18514","volume":"16","author":[{"given":"Amir","family":"Hashemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzad","family":"Mirzavand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7775","published-online":{"date-parts":[[2015]]},"container-title":["Miskolc Mathematical Notes"],"deposited":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T13:51:04Z","timestamp":1542289864000},"score":16.965736,"resource":{"primary":{"URL":"http:\/\/mat76.mat.uni-miskolc.hu\/mnotes\/article\/1369"}},"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.18514\/mmn.2015.1369","ISSN":["1787-2405","1787-2413"],"issn-type":[{"value":"1787-2405","type":"print"},{"value":"1787-2413","type":"electronic"}],"published":{"date-parts":[[2015]]}},{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T19:43:03Z","timestamp":1649014983434},"reference-count":19,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AEU - 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               <jats:p>\n                  Traditional automated in\n                  <jats:italic>silico<\/jats:italic>\n                  functional annotation uses tools like Pfam that rely on sequence similarities for domain annotation. However, structural conservation often exceeds sequence conservation, suggesting an untapped potential for improved annotation through structural similarity. This approach was previously overlooked before the AlphaFold2 introduction due to the need for more high-quality protein structures. Leveraging structural information especially holds significant promise to enhance accurate annotation in diverse proteins across phylogenetic distances.\n                <\/jats:p>\n                <jats:p>\n                  In our study, we evaluated the feasibility of annotating Pfam domains based on structural similarity. To this end, we created a database from segmented full-length protein structures at their domain boundaries, representing the structure of Pfam seeds. We used\n                  <jats:italic>Trypanosomabrucei<\/jats:italic>\n                  , a phylogenetically distant protozoan parasite as our model organism. Its structome was aligned with our database using Foldseek, the ultra-fast structural alignment tool, and the top non-overlapping hits were annotated as domains. Our method identified over 400 new domains in the T.\n                  <jats:italic>brucei<\/jats:italic>\n                  proteome, surpassing the benchmark set by sequence-based tools, Pfam and Pfam-N, with some predictions validated manually. We have also addressed limitations and suggested avenues for further enhancing structure-based domain annotation.\n                <\/jats:p>","DOI":"10.1101\/2023.01.18.524644","type":"posted-content","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T16:45:20Z","timestamp":1674233120000},"source":"Crossref","is-referenced-by-count":1,"title":["Functional domain annotation by structural similarity"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-8410","authenticated-orcid":false,"given":"Poorya","family":"Mirzavand Borujeni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-7090","authenticated-orcid":false,"given":"Reza","family":"Salavati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"D1","key":"2023100512300497000_2023.01.18.524644v2.1","first-page":"D898\u2013D911","article-title":"\u201cVEuPathDB: the eukaryotic pathogen, vector, and host bioinformatics resource center","volume":"50","year":"2022","journal-title":"Nucleic Acids Research"},{"key":"2023100512300497000_2023.01.18.524644v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.01.006"},{"key":"2023100512300497000_2023.01.18.524644v2.3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213712"},{"key":"2023100512300497000_2023.01.18.524644v2.4","doi-asserted-by":"crossref","unstructured":"Bartas, M. , et al. 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