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Elle est associ\u00e9e avec l'accumulation d'incapacit\u00e9s neurologiques, comme des probl\u00e8mes d'\u00e9quilibre, de force, de douleur, de concentration, pour uriner, etc. Malheureusement les traitements actuellement disponibles pour la SEP n'aident pas tous les patients. En particulier les personnes atteintes d'une forme progressive de la SEP, qui sont en g\u00e9n\u00e9ral moins jeunes, ne r\u00e9pondent pas bien aux traitements. L'\u00e9pilepsie r\u00e9fractaire au traitement est une autre condition neurologique chronique qui ne r\u00e9pond pas bien \u00e0 la m\u00e9dication. Elle est caract\u00e9ris\u00e9e par la survenue de convulsions r\u00e9currentes malgr\u00e9 la prise ad\u00e9quate de m\u00e9dication anti-\u00e9pileptique.\n\nLes cellules immunitaires (globules blancs) qui aident \u00e0 combattre les infections et les tumeurs peuvent devenir chez certaines personnes et dans certaines circonstances trop inflammatoires. Les cellules immunitaires inflammatoires parfois infiltrent et attaquent de fa\u00e7on aberrante le cerveau et la moelle \u00e9pini\u00e8re. Ces cellules immunitaires inflammatoires peuvent \u00eatre dommageables pour les cellules du cerveau et de la moelle, et leur pr\u00e9sence peut contribuer \u00e0 causer des probl\u00e8mes de fonctionnement neurologique comme ceux d\u00e9crits en SEP et en \u00e9pilepsie r\u00e9fractaire. Les cellules immunitaires inflammatoires sont d'ailleurs plus fr\u00e9quentes dans le sang des personnes atteintes de SEP, et pourraient augmenter avec l'\u00e2ge. De plus, nous avons d\u00e9couvert que certaines cellules immunitaires inflammatoires sont aussi plus pr\u00e9sentes dans le sang des personnes atteintes d'\u00e9pilepsie r\u00e9fractaire. Mon programme de recherche veut identifier des mol\u00e9cules qui sont utilis\u00e9es par les cellules immunitaires inflammatoires pour interagir avec les cellules du cerveau et de la moelle \u00e9pini\u00e8re et causer du dommage. Mon \u00e9quipe va aussi tester si une di\u00e8te dite 'anti-vieillissement' peut am\u00e9liorer le profil immunitaire et diminuer l'accumulation de probl\u00e8mes neurologiques dans des mod\u00e8les animaux de la SEP, en comparant l'impact chez les m\u00e2les et les femelles. Finalement, nous allons explorer si des sous-types de cellules immunitaires inflammatoires sont plus fr\u00e9quents dans le sang de personnes atteintes d'une cause g\u00e9n\u00e9tique de l'\u00e9pilepsie appel\u00e9e la scl\u00e9rose tub\u00e9reuse de Bourneville, et plus sp\u00e9cialement chez les individus atteints d'\u00e9pilepsie r\u00e9fractaire au traitement, et nous allons explorer si cela corr\u00e8le avec la fr\u00e9quence et la s\u00e9v\u00e9rit\u00e9 des convulsions, avec le dommage au tissu c\u00e9r\u00e9bral et avec les troubles cognitifs. 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