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Trimethobenzamide is used for treating nausea and vomiting\nand administered as its hydrochloride salt. The aim is to develop a novel and environmental friendly\nmethod for large-scale production of itopride and trimethobenzamide.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p> Itopride and trimethobenzamide can be prepared from a common intermediate 4-\n(dimethylaminoethoxy) benzyl amine. The intermediate is prepared from one pot synthesis using Phyrdroxybenzaldehye\nand zinc dust and further reaction of the intermediate with substituted methoxy benzoic\nacid along with boric acid and PEG gives itopride and trimethobenzamide.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The intermediate 4-(dimethylaminoethoxy) benzylamine is prepared by treating p-hydroxybenzaldehyde\nand 2-dimethylaminoethyl chloride. The aldehyde formed is treated with hydroxylamine hydrochloride.\nThe intermediate is confirmed by NMR and the purity is analysed by HPLC.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Both itopride and trimethobenzamide were successfully synthesized by this method. The developed\nmethod is environmental friendly, economical for large-scale production with good yield and purity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179415666180403115032","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T11:11:21Z","timestamp":1522926681000},"page":"572-575","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Efficient and Improved Process for the Synthesis of Itopride Hydrochloride and Trimethobenzamide Hydrochloride"],"prefix":"10.2174","volume":"15","author":[{"given":"Ponnusamy","family":"Kannan","sequence":"first","affiliation":[{"name":"Department of Chemistry, B.S. 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A simple and rapid reverse phase ultra-performance liquid chromatographic (RP-UPLC) method for determination of TMB\u00b7HCI have been developed and validated using the ICH guideline. The effective chromatographic separations were achieved on Acquity CSH Phenyl-Hexyl, 2.1 x 100 mm 1.7\u00b5m column and reverse phase with linear gradient elution. The mobile phase-A is 0.1% Nonaflurobutane -1 sulfonic acid in water while mixture of 35:65 ratio of 0.1 % Nonaflurobutane -1-sulphonic acid in purified water with acetonitrile as mobile phase-B delivered\u00a0 flow rate 0.4 mL min\u22121 using PDA\/UV detector. The column oven temperature is 40\u00b0C.The injection volume is 1.0\u03bcL.The method yields a well separated Trimethobenzamide (TMB) peak from the impurities. These impurity peaks are then identified. The degradation of TMB under various stress condition is studied. The total run time of the method is reduced to 5 mins i.e. to 25 % of reported method The new RP-UPLC method is precise, accurate as well as rapid and qualifies all the criteria of linearity, stability and robustness.<\/jats:p>","DOI":"10.22376\/ijpbs.2018.9.2.p177-184","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T07:12:48Z","timestamp":1524121968000},"page":"177-184","source":"Crossref","is-referenced-by-count":0,"title":["RP-UPLC method development and validation for quantitative analysis of antiemetic Trimethobenzamide hydrochloride"],"prefix":"10.22376","author":[{"family":"VM DHALAPE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"ST KHADANGALE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"RV PINJARI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51400","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Hurley JH, Eshelman FN. Trimethobenzamide HCI in the treatment of nausea vomiting associated with antineoplastic chemotherapy. J.Clinic. Pharm. 1980 May;20(5-6):352-6.","DOI":"10.1177\/009127008002000508"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. FriedmanBW, HochbergM, Esses D, BijurPE, Corbo J, et al. A clinical trial of Trimethobenzamide\/Diphenhydramine verse sumatriptan for acute migration. Headache. The Journal of Head and Face Pain. 2006;46(6):934-41.","DOI":"10.1111\/j.1526-4610.2006.00467.x"},{"issue":"3","key":"ref2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/0333102414535997","article-title":"Canadian Headache society systematic review and recommendation on the treatment of migraine pain in emergency settings","volume":"35","author":"Orr","year":"2015","unstructured":"3. Orr SL, Aube M, Becker WJ, Davenport WJ, Dilli E, Dodick D, Giammarco R, GladstoneJ, Leroux E, Pim H, Dickinson G. 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