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The effect of APV on the sound-evoked responses of principal, PV, SOM and VIP neurons."],"prefix":"10.7554","member":"4374","deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T09:11:49Z","timestamp":1535101909000},"score":15.460803,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/29893\/figures#fig3s1"}},"subtitle":["(a) Transcranial fluorescence responses of principal neurons to 12 kHz sounds of 40 and 70 dB SPL before and after APV infusion. (b) Average responses of principal neurons to 12 kHz sounds of different intensities in control (black) and after APV (gold; control vs. APV for 30 dB: p=0.005, 40 dB: p=0.016, 50 dB: p=0.039, 60 dB: p=0.006, 70 dB: p=0.042; 80 dB: p=0.014, n\u00a0=\u00a06 mice, paired t-tests). (c) Same as in (a) but for PV neurons. (d) Same as in (b) but for PV neurons (control vs. APV for 30 dB: p=0.001, 40 dB: p=0.017, 50 dB: p=0.003, 60 dB: p=0.005, 70 dB: p=0.001; 80 dB: p&lt;0.001, n\u00a0=\u00a06 mice, paired t-tests). (e) Same as in (a) but for SOM neurons. (f) Same as in (b) but for SOM neurons (control vs. APV for 30 dB: p=0.018, 40 dB: p=0.036, 50 dB: p=0.039, 60 dB: p=0.001, 70 dB: p=0.024; 80 dB: p=0.011, n\u00a0=\u00a04 mice, paired t-tests). (g) Same as in (a) but for VIP neurons. (h) Same as in (b) but for VIP neurons (control vs. APV for 30 dB: p=0.005, 40 dB: p=0.016, 50 dB: p=0.039, 60 dB: p=0.006, 70 dB: p=0.033; 80 dB: p=0.042 n=4 mice, paired t-tests). Detailed values: (b) 30 dB SPL: control: 2.6 \u00b1 0.5% \u0394F\/F, vs APV, p=0.005; 40 dB SPL: control: 2.8 \u00b1 0.6% \u0394F\/F, vs. APV, p=0.01; 50 dB SPL: control: 3.3 \u00b1 0.9% \u0394F\/F, vs. APV, p=0.04; 60 dB SPL: control: 4.3 \u00b1 1.4% \u0394F\/F, vs. APV, p=0.006, 70 dB SPL: control: 4.9 \u00b1 1.2% \u0394F\/F, vs. APV, p=0.04; 80 dB SPL: control: 6.3 \u00b1 1.9% \u0394F\/F, vs APV, p=0.01, paired t-tests, n\u00a0=\u00a06 mice. (c) 30 dB SPL: control: 4.4 \u00b1 0.7% \u0394F\/F, vs. APV, p=0.001; 40 dB SPL: control: 5.1 \u00b1 1.1% \u0394F\/F, vs. APV, p=0.001; 50 dB SPL: control: 6.6 \u00b1 1.3% \u0394F\/F, vs. APV, p=0.003; 60 dB SPL: control: 8.8 \u00b1 1.3% \u0394F\/F, vs. APV, p=0.005, 70 dB SPL: control: 9.5 \u00b1 1.5% \u0394F\/F, vs. APV, p=0.001; 80 dB SPL: control: 9.3 \u00b1 1.5% \u0394F\/F, vs. APV, p=0.001, paired t-tests, n\u00a0=\u00a06 mice. (e) 30 dB SPL: control: 5.3 \u00b1 1.5% \u0394F\/F, vs. APV, p=0.02; 40 dB SPL: control: 4.7 \u00b1 1.2% \u0394F\/F, vs. APV, p=0.04; 50 dB SPL: control: 5.8 \u00b1 1.2% \u0394F\/F, vs APV, p=0.04; 60 dB SPL: control: 11.8 \u00b1 3.1% \u0394F\/F, vs. APV, p=0.001, 70 dB SPL: control: 12.0 \u00b1 3.1% \u0394F\/F, vs. APV, p=0.02; 80 dB SPL: control: 22.5 \u00b1 5.2% \u0394F\/F, vs. APV, p=0.01, paired t-tests, n\u00a0=\u00a04 mice. (f) 30 dB SPL: control: 5.4 \u00b1 2.3% \u0394F\/F, vs. APV, p=0.03; 40 dB SPL: control: 7.0 \u00b1 3.4% \u0394F\/F, vs. APV, p=0.009; 50 dB SPL: control: 9.3 \u00b1 4.2% \u0394F\/F, vs. APV, p=0.03; 60 dB SPL: control: 13.0 \u00b1 4.7% \u0394F\/F, vs. APV, p=0.03, 70 dB SPL: control: 14.6 \u00b1 5.2% \u0394F\/F, vs. APV, p=0.03; 80 dB SPL: control: 12.6 \u00b1 4.8% \u0394F\/F, vs. APV, p=0.04, paired t-tests, n\u00a0=\u00a04 mice."],"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.7554\/elife.29893.008","relation":{"is-component-of":[{"id-type":"doi","id":"10.7554\/eLife.29893","asserted-by":"object"}]}},{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:03:08Z","timestamp":1772269388770,"version":"3.50.1"},"reference-count":0,"publisher":"PeerJ","content-domain":{"domain":[],"crossmark-restriction":false},"DOI":"10.7717\/peerj.3155\/supp-1","type":"component","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T04:06:47Z","timestamp":1492056407000},"source":"Crossref","is-referenced-by-count":0,"title":["Figure S1:  Effect of metformin on pancreatic islet in db\/db mice."],"prefix":"10.7717","member":"4443","deposited":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T04:06:54Z","timestamp":1492056414000},"score":15.35255,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/3155\/supp-1"}},"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.7717\/peerj.3155\/supp-1","relation":{"is-component-of":[{"id-type":"doi","id":"10.7717\/peerj.3155","asserted-by":"object"}]}},{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:55:50Z","timestamp":1772268950867,"version":"3.50.1"},"reference-count":0,"publisher":"PeerJ","content-domain":{"domain":[],"crossmark-restriction":false},"DOI":"10.7717\/peerj.19234\/fig-3","type":"component","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:07:01Z","timestamp":1750910821000},"source":"Crossref","is-referenced-by-count":0,"title":["Figure 3: Histograms of click parameters: peak frequency, centroid frequency, inter-click interval (ICI), \u2018rms\u2019 bandwidth, \u2018\u22123 dB\u2019 bandwidth, \u2018\u221210 dB\u2019 bandwidth, \u2018rms\u2019 duration, \u2018\u221210 dB\u2019 duration and \u2018\u221220 dB\u2019 duration, see Supplemental Materials for formal definitions."],"prefix":"10.7717","member":"4443","deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:07:09Z","timestamp":1750910829000},"score":15.26346,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/19234\/fig-3"}},"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.7717\/peerj.19234\/fig-3","relation":{"is-component-of":[{"id-type":"doi","id":"10.7717\/peerj.19234","asserted-by":"object"}]}},{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:18:55Z","timestamp":1739942335338,"version":"3.37.3"},"reference-count":3,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>(<jats:italic toggle=\"yes\">Am J Obstet Gynecol<\/jats:italic>. 2024; 230:446.e1\u2013446.e6. doi:10.1016\/j.ajog.2023.09.092)<\/jats:p>\n          <jats:p>Cesarean deliveries (CD) are highly prevalent in the United States, with over 1.1 million performed in 2020. Despite this, standardized pain management at discharge is lacking. Many patients still receive excess opioids at discharge, often leading to unused medication that can contribute to misuse and addiction. Studies show similar opioid prescriptions for all patients regardless of varying pain levels and opioid requirements, highlighting the need to address overprescribing. In 2021, updated guidelines from the American College of Obstetricians and Gynecologists Committee on Clinical Consensus-Obstetrics recommended a multimodal approach, combining acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids, tailored to individual needs.<\/jats:p>","DOI":"10.1097\/01.aoa.0001097712.99980.c1","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:09:33Z","timestamp":1739902173000},"page":"54-56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative Analgesia A Personalized Protocol for Prescribing Opioids After Cesarean Delivery: Leveraging the Electronic Medical Record to Reduce Outpatient Opioid Prescriptions"],"prefix":"10.1097","volume":"45","author":[{"given":"CS","family":"Imo","sequence":"first","affiliation":[]},{"given":"DA","family":"Macias","sequence":"additional","affiliation":[]},{"given":"DD","family":"McIntire","sequence":"additional","affiliation":[]},{"given":"J","family":"McGuire","sequence":"additional","affiliation":[]},{"given":"DB","family":"Nelson","sequence":"additional","affiliation":[]},{"given":"EL","family":"Duryea","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"R1-20250218","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/jamasurg.2020.3527","article-title":"Assessing the 5-multiplier calculation to reduce discharge opioid prescription volumes after inpatient surgery","volume":"155","author":"Day","year":"2020","journal-title":"JAMA Surg"},{"key":"R2-20250218","doi-asserted-by":"crossref","first-page":"109710","DOI":"10.1016\/j.drugalcdep.2022.109710","article-title":"The prevalence of opioid use disorder in Kentucky\u2019s counties: a two-year multi-sample capture-recapture analysis","volume":"242","author":"Thompson","year":"2023","journal-title":"Drug Alcohol Depend"},{"key":"R3-20250218","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/jamainternmed.2020.7383","article-title":"Eastern Kentucky\u2019s Lost Generation and the Echoes That Remain\u2014The Aftermath of the Opioid Epidemic","volume":"181","author":"Barnett","year":"2021","journal-title":"JAMA Intern Med"}],"container-title":["Obstetric Anesthesia Digest"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/01.aoa.0001097712.99980.c1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:09:37Z","timestamp":1739902177000},"score":15.260689,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/01.aoa.0001097712.99980.c1"}},"issued":{"date-parts":[[2025,2,20]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/01.aoa.0001097712.99980.c1","ISSN":["0275-665X","1536-5395"],"issn-type":[{"value":"0275-665X","type":"print"},{"value":"1536-5395","type":"electronic"}],"published":{"date-parts":[[2025,2,20]]}}],"items-per-page":20,"query":{"start-index":0,"search-terms":"cs.DB"}}}