{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":198257,"items":[{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:49:23Z","timestamp":1766983763599,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002203","name":"Brain Tumour Charity","doi-asserted-by":"publisher","award":["GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435"],"award-info":[{"award-number":["GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435","GN-000435"]}],"id":[{"id":"10.13039\/501100002203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Surviv"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract\n<\/jats:title>\n Purpose<\/jats:title>\n Lower-grade gliomas (LGG) are mostly diagnosed in working-aged adults and rarely cured. LGG patients may face chronic impairments (e.g. fatigue, cognitive deficits). Self-management can improve clinical and psychosocial outcomes, yet how LGG patients self-manage the consequences of their tumour and its treatment is not fully understood. This study, therefore, aimed to identify and understand how LGG patients engage in the self-management of their condition.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n A diverse group of 28 LGG patients (age range 22\u201369\u00a0years; male n<\/jats:italic>\u2009=\u200916, female n<\/jats:italic>\u2009=\u200912; mean time since diagnosis\u2009=\u20098.7\u00a0years) who had completed primary treatment, were recruited from across the United Kingdom. Semi-structured interviews were conducted. Informed by a self-management strategy framework developed in cancer, directed content analysis identified and categorised self-management types and strategies used by patients.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n Overall, 20 self-management strategy types, comprising 123 self-management strategies were reported; each participant detailed extensive engagement in self-management. The most used strategy types were \u2018using support\u2019 (n<\/jats:italic>\u2009=\u200928), \u2018creating a healthy environment\u2019 (n<\/jats:italic>\u2009=\u200928), \u2018meaning making\u2019 (n<\/jats:italic>\u2009=\u200927), and \u2018self-monitoring\u2019 (n<\/jats:italic>\u2009=\u200927). The most used strategies were \u2018accepting the tumour and its consequences\u2019 (n<\/jats:italic>\u2009=\u200926), \u2018receiving support from friends (n<\/jats:italic>\u2009=\u200924) and family\u2019 (n<\/jats:italic>\u2009=\u200924), and \u2018reinterpreting negative consequences\u2019 (n<\/jats:italic>\u2009=\u200924).<\/jats:p>\n <\/jats:sec>\n Conclusions<\/jats:title>\n This study provides a comprehensive understanding of the strategies used by LGG patients to self-manage their health and wellbeing, with a diverse, and substantial number of self-management strategies reported.<\/jats:p>\n <\/jats:sec>\n Implications for Cancer Survivors<\/jats:title>\n The findings will inform the development of a supported self-management intervention for LGG patients, which will be novel for this patient group.\n<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s11764-023-01425-x","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:02:37Z","timestamp":1689328957000},"page":"1837-1850","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identifying and understanding how people living with a lower-grade glioma engage in self-management"],"prefix":"10.1007","volume":"18","author":[{"given":"Ben","family":"Rimmer","sequence":"first","affiliation":[]},{"given":"Michelle","family":"Balla","sequence":"additional","affiliation":[]},{"given":"Lizzie","family":"Dutton","sequence":"additional","affiliation":[]},{"given":"Joanne","family":"Lewis","sequence":"additional","affiliation":[]},{"given":"Morven C.","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Rich\u00e9al","family":"Burns","sequence":"additional","affiliation":[]},{"given":"Pamela","family":"Gallagher","sequence":"additional","affiliation":[]},{"given":"Sophie","family":"Williams","sequence":"additional","affiliation":[]},{"given":"Vera","family":"Ara\u00fajo-Soares","sequence":"additional","affiliation":[]},{"given":"Tracy","family":"Finch","sequence":"additional","affiliation":[]},{"given":"Fiona","family":"Menger","sequence":"additional","affiliation":[]},{"given":"Linda","family":"Sharp","sequence":"additional","affiliation":[]},{"name":"on behalf of the Ways Ahead study team","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"Bauchet L. 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However, people with lower-grade gliomas (LGG) may face chronic tumour- and\/or treatment-related symptoms and impairments (e.g. cognitive deficits, seizures), which could influence their ability to self-manage. Our study aimed to identify and understand the barriers and facilitators to self-management in people with LGG.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted semi-structured interviews with 28 people with LGG across the United Kingdom, who had completed primary treatment. Sixteen participants were male, mean age was 50.4\u00a0years, and mean time since diagnosis was 8.7\u00a0years. Interviews were audio-recorded and transcribed. Following inductive open coding, we deductively mapped codes to Schulman-Green et al.\u2019s framework of factors influencing self-management, developed in chronic illness.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Data suggested extensive support for all five framework categories (\u2018Personal\/lifestyle characteristics\u2019, \u2018Health status\u2019, \u2018Resources\u2019, \u2018Environmental characteristics\u2019, \u2018Healthcare system\u2019), encompassing all 18 factors influencing self-management. How people with LGG experience many of these factors appears somewhat distinct from other cancers; participants described multiple, often co-occurring, challenges, primarily with knowledge and acceptance of their incurable condition, the impact of seizures and cognitive deficits, transport difficulties, and access to (in)formal support. Several factors were on a continuum, for example, sufficient knowledge was a facilitator, whereas lack thereof, was a barrier to self-management.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n People with LGG described distinctive experiences with wide-ranging factors influencing their ability to self-manage.<\/jats:p>\n <\/jats:sec>\n \n Implications for cancer survivors<\/jats:title>\n These findings will improve awareness of the potential challenges faced by people with LGG around self-management and inform development of self-management interventions for this population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s11764-024-01572-9","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T10:02:54Z","timestamp":1711015374000},"page":"1554-1567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Barriers and facilitators to self-management in people living with a lower-grade glioma"],"prefix":"10.1007","volume":"19","author":[{"given":"Ben","family":"Rimmer","sequence":"first","affiliation":[]},{"given":"Michelle","family":"Balla","sequence":"additional","affiliation":[]},{"given":"Lizzie","family":"Dutton","sequence":"additional","affiliation":[]},{"given":"Sophie","family":"Williams","sequence":"additional","affiliation":[]},{"given":"Vera","family":"Ara\u00fajo-Soares","sequence":"additional","affiliation":[]},{"given":"Pamela","family":"Gallagher","sequence":"additional","affiliation":[]},{"given":"Tracy","family":"Finch","sequence":"additional","affiliation":[]},{"given":"Joanne","family":"Lewis","sequence":"additional","affiliation":[]},{"given":"Rich\u00e9al","family":"Burns","sequence":"additional","affiliation":[]},{"given":"Fiona","family":"Menger","sequence":"additional","affiliation":[]},{"given":"Linda","family":"Sharp","sequence":"additional","affiliation":[]},{"name":"on behalf of the Ways Ahead study team","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"issue":"1","key":"1572_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3322\/caac.20093","volume":"61","author":"R McCorkle","year":"2011","unstructured":"McCorkle R, Ercolano E, Lazenby M, Schulman-Green D, Schilling LS, Lorig K, Wagner EH. 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Patients with tumours showing O6<\/jats:sup>-methylguanine-DNA methyltransferase (MGMT) promoter methylation represent around 40% of newly diagnosed GBM. Relapse\/tumour recurrence is inevitable. There is no agreed standard treatment for patients with GBM, therefore, it is aimed at delaying further tumour progression and maintaining health-related quality of life (HRQoL). Limited clinical trial data exist using cannabinoids in combination with temozolomide (TMZ) in this setting, but early phase data demonstrate prolonged overall survival compared to TMZ alone, with few additional side effects. Jazz Pharmaceuticals (previously GW Pharma Ltd.) have developed nabiximols (trade name Sativex\u00ae), an oromucosal spray containing a blend of cannabis plant extracts, that we aim to assess for preliminary efficacy in patients with recurrent GBM.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n ARISTOCRAT is a phase II, multi-centre, double-blind, placebo-controlled, randomised trial to assess cannabinoids in patients with recurrent MGMT methylated GBM who are suitable for treatment with TMZ. Patients who have relapsed\u2009\u2265\u20093 months after completion of initial first-line treatment will be randomised 2:1 to receive either nabiximols or placebo in combination with TMZ. The primary outcome is overall survival time defined as the time in whole days from the date of randomisation to the date of death from any cause. Secondary outcomes include overall survival at 12 months, progression-free survival time, HRQoL (using patient reported outcomes from QLQ-C30, QLQ-BN20 and EQ-5D-5L questionnaires), and adverse events.<\/jats:p>\n <\/jats:sec>\n Discussion<\/jats:title>\n Patients with recurrent MGMT promoter methylated GBM represent a relatively good prognosis sub-group of patients with GBM. However, their median survival remains poor and, therefore, more effective treatments are needed. The phase II design of this trial was chosen, rather than phase III, due to the lack of data currently available on cannabinoid efficacy in this setting. A randomised, double-blind, placebo-controlled trial will ensure an unbiased robust evaluation of the treatment and will allow potential expansion of recruitment into a phase III trial should the emerging phase II results warrant this development.<\/jats:p>\n <\/jats:sec>\n Trial registration<\/jats:title>\n ISRCTN: 11460478. ClinicalTrials.Gov: NCT05629702.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12885-023-11792-4","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T16:02:27Z","timestamp":1705334547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Divyalakshmi","family":"Bhaskaran","sequence":"first","affiliation":[]},{"given":"Joshua","family":"Savage","sequence":"additional","affiliation":[]},{"given":"Amit","family":"Patel","sequence":"additional","affiliation":[]},{"given":"Fiona","family":"Collinson","sequence":"additional","affiliation":[]},{"given":"Rhys","family":"Mant","sequence":"additional","affiliation":[]},{"given":"Florien","family":"Boele","sequence":"additional","affiliation":[]},{"given":"Lucy","family":"Brazil","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Meade","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Buckle","sequence":"additional","affiliation":[]},{"given":"Si\u00e2n","family":"Lax","sequence":"additional","affiliation":[]},{"given":"Lucinda","family":"Billingham","sequence":"additional","affiliation":[]},{"given":"Susan C.","family":"Short","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"11792_CR1","doi-asserted-by":"publisher","unstructured":"Brodbelt A, Greenberg D, Winters T et al. 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This is primarily due to their location within the CNS, hindering adequate drug delivery and tumour access via surgery. Furthermore, CNS cancer cells are highly plastic, an adaptive property that enables them to bypass targeted treatment strategies and develop drug resistance. Potassium ion channels have long been implicated in the progression of many cancers due to their integral role in several hallmarks of the disease. Here, we will explore this relationship further, with a focus on malignant CNS cancers, including high-grade glioma (HGG). HGG is the most lethal form of primary brain tumour in adults, with the majority of patient mortality attributed to drug-resistant secondary tumours. Hence, targeting proteins that are integral to cellular plasticity could reduce tumour recurrence, improving survival. This review summarises the role of potassium ion channels in malignant CNS cancers, specifically how they contribute to proliferation, invasion, metastasis, angiogenesis, and plasticity. We will also explore how specific modulation of these proteins may provide a novel way to overcome drug resistance and improve patient outcomes.<\/jats:p>","DOI":"10.3390\/cancers14194767","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:03:10Z","timestamp":1664485390000},"page":"4767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potassium Ion Channels in Malignant Central Nervous System Cancers"],"prefix":"10.3390","volume":"14","author":[{"given":"Yasmin","family":"Boyle","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, Perth Children\u2019s Hospital, 15 Hospital Ave, Nedlands, Perth, WA 6009, Australia"},{"name":"School of Biomedicine, The University of Western Australia, 35 Stirling Hwy, Crawley, Perth, WA 6009, Australia"}]},{"given":"Terrance G.","family":"Johns","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth Children\u2019s Hospital, 15 Hospital Ave, Nedlands, Perth, WA 6009, Australia"},{"name":"School of Biomedicine, The University of Western Australia, 35 Stirling Hwy, Crawley, Perth, WA 6009, Australia"}]},{"given":"Emily V.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth Children\u2019s Hospital, 15 Hospital Ave, Nedlands, Perth, WA 6009, Australia"},{"name":"School of Biomedicine, The University of Western Australia, 35 Stirling Hwy, Crawley, Perth, WA 6009, Australia"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10162-007-0082-y","article-title":"Ion Channel Gene Expression in the Inner Ear","volume":"8","author":"Gabashvili","year":"2007","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cbdd.12237","article-title":"Potassium Channels: Structures, Diseases, and Modulators","volume":"83","author":"Tian","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_3","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2002). Ion Channels and the Electrical Properties of Membranes. Molecular Biology of the Cell, Garland Science. [4th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3389\/fphys.2018.01661","article-title":"Emerging Roles of the Membrane Potential: Action Beyond the Action Potential","volume":"9","author":"Stacey","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_5","unstructured":"Chrysafides, S.M., Bordes, S., and Sharma, S. (2022). Physiology, Resting Potential. StatPearls, StatPearls Publishing."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/s41467-018-06338-3","article-title":"Astrocytes Integrate and Drive Action Potential Firing in Inhibitory Subnetworks","volume":"9","author":"Deemyad","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCEP.108.789081","article-title":"Cardiac Ion Channels","volume":"2","author":"Grant","year":"2009","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/00365519709057819","article-title":"Human Red Blood Cell Membrane Potential and Fluidity in Glucose Solutions","volume":"57","author":"Zavodnik","year":"1997","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1152\/jn.1998.79.5.2782","article-title":"Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells","volume":"79","author":"Bordey","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.4161\/cc.8.21.9888","article-title":"Bioelectric Controls of Cell Proliferation","volume":"8","author":"Blackiston","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1126\/science.56781","article-title":"Induction of Mitosis in Mature Neurons in Central Nervous System by Sustained Depolarization","volume":"192","author":"Cone","year":"1976","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Griffin, M., Khan, R., Basu, S., and Smith, S. (2020). Ion Channels as Therapeutic Targets in High Grade Gliomas. Cancers, 12.","DOI":"10.3390\/cancers12103068"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20130094","DOI":"10.1098\/rstb.2013.0094","article-title":"Potassium Channels in Cell Cycle and Cell Proliferation","volume":"369","author":"Urrego","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.bbamem.2014.12.016","article-title":"Ion Channel Expression as Promising Cancer Biomarker","volume":"1848","author":"Lastraioli","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3345\/kjp.2014.57.1.1","article-title":"Channelopathies","volume":"57","author":"Kim","year":"2014","journal-title":"Korean J. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","article-title":"Ion Channels and the Hallmarks of Cancer","volume":"16","author":"Prevarskaya","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The Hallmarks of Cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","article-title":"Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth","volume":"78","author":"Jackson","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/01.RES.85.9.e33","article-title":"Molecular Cloning and Characterization of the Intermediate-Conductance Ca2+-Activated K+ Channel in Vascular Smooth Muscle: Relationship between K(Ca) Channel Diversity and Smooth Muscle Cell Function","volume":"85","author":"Neylon","year":"1999","journal-title":"Circ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15843","DOI":"10.1074\/jbc.M112.427187","article-title":"The Intermediate Conductance Calcium-Activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-Dependent Signaling","volume":"288","author":"Bi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fphys.2013.00227","article-title":"Intracellular Ion Channels and Cancer","volume":"4","author":"Leanza","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/cancers7020813","article-title":"Voltage-Gated Ion Channels in Cancer Cell Proliferation","volume":"7","author":"Rao","year":"2015","journal-title":"Cancers"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3635","article-title":"The Roles of K+ Channels in Cancer","volume":"14","author":"Pardo","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3181\/0711-MR-308","article-title":"An Unexpected Role for Ion Channels in Brain Tumor Metastasis","volume":"233","author":"Sontheimer","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.bbamem.2014.12.008","article-title":"Involvement of Potassium Channels in the Progression of Cancer to a More Malignant Phenotype","volume":"1848","author":"Comes","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1159\/000235730","article-title":"Tetraethylammonium Inhibits Glioma Cells via Increasing Production of Intracellular Reactive Oxygen Species","volume":"55","author":"Yang","year":"2009","journal-title":"Chemotherapy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1097-4547(19970415)48:2<122::AID-JNR4>3.0.CO;2-E","article-title":"4-Aminopyridine Causes Apoptosis and Blocks an Outward Rectifier K+ Channel in Malignant Astrocytoma Cell Lines","volume":"48","author":"Chin","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1159\/000335850","article-title":"Curcumin Blocks Kv11.1 (Erg) Potassium Current and Slows Proliferation in the Infant Acute Monocytic Leukemia Cell Line THP-1","volume":"28","author":"Banderali","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000480643","article-title":"Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells","volume":"25","author":"Venturini","year":"2017","journal-title":"Neurosignals"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s00018-015-1948-5","article-title":"Structure of Potassium Channels","volume":"72","author":"Kuang","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fphar.2012.00063","article-title":"Regulation of Voltage-Activated K+ Channel Gating by Transmembrane \u03b2 Subunits","volume":"3","author":"Sun","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nature01580","article-title":"X-ray Structure of a Voltage-Dependent K+ Channel","volume":"423","author":"Jiang","year":"2003","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity","volume":"280","author":"Doyle","year":"1998","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/01.RES.82.7.739","article-title":"Inactivation of Voltage-Gated Cardiac K+ Channels","volume":"82","author":"Rasmusson","year":"1998","journal-title":"Circ. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583500002894","article-title":"Voltage Gating of Ion Channels","volume":"27","author":"Sigworth","year":"1994","journal-title":"Q. Rev. Biophys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1523\/JNEUROSCI.2765-20.2021","article-title":"Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons","volume":"41","author":"Sabater","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"He, K., McCord, M.C., Hartnett, K.A., and Aizenman, E. (2015). Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129498"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0196-17","article-title":"Positional Cloning of a Novel Potassium Channel Gene: KVLQT1 Mutations Cause Cardiac Arrhythmias","volume":"12","author":"Wang","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neuron.2013.10.040","article-title":"Conduits of Life\u2019s Spark: A Perspective on Ion Channel Research since the Birth of Neuron","volume":"80","author":"Isacoff","year":"2013","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"354262","DOI":"10.1155\/2013\/354262","article-title":"Slack, Slick and Sodium-Activated Potassium Channels","volume":"2013","author":"Kaczmarek","year":"2013","journal-title":"ISRN Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.201404136","article-title":"Targeting Potassium Channels in Cancer","volume":"206","author":"Huang","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fnmol.2018.00258","article-title":"Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System","volume":"11","author":"Kshatri","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1085\/jgp.200810129","article-title":"Measuring the Influence of the BKCa \u03b21 Subunit on Ca2+ Binding to the BKCa Channel","volume":"133","author":"Sweet","year":"2009","journal-title":"J. Gen. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.tins.2010.06.004","article-title":"BK Channel Activation: Structural and Functional Insights","volume":"33","author":"Lee","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/bs.irn.2016.04.001","article-title":"BK Channels in the Central Nervous System","volume":"128","author":"Contet","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fnins.2014.00103","article-title":"The Contribution of Astrocytes to the Regulation of Cerebral Blood Flow","volume":"8","author":"Howarth","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nn1779","article-title":"Local Potassium Signaling Couples Neuronal Activity to Vasodilation in the Brain","volume":"9","author":"Filosa","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0896-6273(03)00096-5","article-title":"The Sodium-Activated Potassium Channel Is Encoded by a Member of the Slo Gene Family","volume":"37","author":"Yuan","year":"2003","journal-title":"Neuron"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nn.2313","article-title":"Na+-Activated K+ Channels Express a Large Delayed Outward Current in Neurons during Normal Physiology","volume":"12","author":"Budelli","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1101\/lm.037820.114","article-title":"The Sodium-Activated Potassium Channel Slack Is Required for Optimal Cognitive Flexibility in Mice","volume":"22","author":"Bausch","year":"2015","journal-title":"Learn. Mem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ng.2441","article-title":"De Novo Gain-of-Function KCNT1 Channel Mutations Cause Malignant Migrating Partial Seizures of Infancy","volume":"44","author":"Barcia","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"796136","DOI":"10.3389\/fcell.2021.796136","article-title":"Inwardly Rectifying Potassium Channel Kir2.1 and Its \u201cKir-Ious\u201d Regulation by Protein Trafficking and Roles in Development and Disease","volume":"9","author":"Hager","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.1016\/j.ydbio.2018.02.012","article-title":"Kir2.1 Is Important for Efficient BMP Signaling in Mammalian Face Development","volume":"444","author":"Belus","year":"2018","journal-title":"Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/303250a0","article-title":"Acetylcholine Activation of Single Muscarinic K+ Channels in Isolated Pacemaker Cells of the Mammalian Heart","volume":"303","author":"Sakmann","year":"1983","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0092-8674(02)01227-8","article-title":"Structural Basis of Inward Rectification: Cytoplasmic Pore of the G Protein-Gated Inward Rectifier GIRK1 at 1.8 \u00c5 Resolution","volume":"111","author":"Nishida","year":"2002","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yjmcc.2009.08.013","article-title":"Cardiac Strong Inward Rectifier Potassium Channels","volume":"48","author":"Anumonwo","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1113\/jphysiol.2014.287268","article-title":"The Family of K2P Channels: Salient Structural and Functional Properties","volume":"593","author":"Feliciangeli","year":"2015","journal-title":"J. Physiol."},{"key":"ref_58","first-page":"228","article-title":"Understanding the Cap Structure in K2P Channels","volume":"7","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1126\/science.1213274","article-title":"Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1","volume":"335","author":"Miller","year":"2012","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1213808","article-title":"Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel","volume":"335","author":"Brohawn","year":"2012","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/bph.14518","article-title":"Two-Pore Domain Potassium Channels: Emerging Targets for Novel Analgesic Drugs: IUPHAR Review 26","volume":"176","author":"Gada","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-4598-5-41","article-title":"Overexpression of Eag1 Potassium Channels in Clinical Tumours","volume":"5","author":"Hemmerlein","year":"2006","journal-title":"Mol. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Luis, E., Anaya-Hern\u00e1ndez, A., Le\u00f3n-S\u00e1nchez, P., and Dur\u00e1n-Past\u00e9n, M.L. (2022). The Kv10.1 Channel: A Promising Target in Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158458"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1469-7793.1998.317be.x","article-title":"An Ether -\u00e0-Go-Go K+ Current, Ih-Eag, Contributes to the Hyperpolarization of Human Fusion-Competent Myoblasts","volume":"512","author":"Bijlenga","year":"1998","journal-title":"J. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/365445a0","article-title":"Ether-\u00e0-Go-Go Encodes a Voltage-Gated Channel Permeable to K+ and Ca2+ and Modulated by CAMP","volume":"365","author":"Pardo","year":"1993","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.143.3.767","article-title":"Cell Cycle-Related Changes in the Conducting Properties of r-Eag K+ Channels","volume":"143","author":"Pardo","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1093\/emboj\/18.20.5540","article-title":"Oncogenic Potential of EAG K+ Channels","volume":"18","author":"Pardo","year":"1999","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.ijbiomac.2018.01.144","article-title":"Functional Role of Kv1.1 and Kv1.3 Channels in the Neoplastic Progression Steps of Three Cancer Cell Lines, Elucidated by Scorpion Peptides","volume":"111","author":"Aissaoui","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3835(02)00348-8","article-title":"Expression and Activity of Potassium Ion Channels in Human Prostate Cancer","volume":"186","author":"Abdul","year":"2002","journal-title":"Cancer Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00232-006-0065-7","article-title":"Reduced Kv1.3 Potassium Channel Expression in Human Prostate Cancer","volume":"214","author":"Abdul","year":"2006","journal-title":"J. Membr. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5483\/BMBRep.2009.42.8.535","article-title":"Kv1.3 Voltage-Gated K+ Channel Subunit as a Potential Diagnostic Marker and Therapeutic Target for Breast Cancer","volume":"42","author":"Jang","year":"2009","journal-title":"BMB Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000227810","article-title":"DNA Methylation of K(v)1.3 Potassium Channel Gene Promoter Is Associated with Poorly Differentiated Breast Adenocarcinoma","volume":"24","author":"Brevet","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"19245","DOI":"10.3390\/ijms140919245","article-title":"Voltage-Gated Potassium Channel Kv1.3 Is Highly Expressed in Human Osteosarcoma and Promotes Osteosarcoma Growth","volume":"14","author":"Wu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1159\/000430223","article-title":"Biophysical Characterization and Expression Analysis of Kv1.3 Potassium Channel in Primary Human Leukemic B Cells","volume":"37","author":"Szabo","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/092986712798992048","article-title":"Targeting the Voltage-Dependent K+ Channels Kv1.3 and Kv1.5 as Tumor Biomarkers for Cancer Detection and Prevention","volume":"19","author":"Felipe","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3892\/ol.2012.718","article-title":"Increased Voltage-Dependent K+ Channel Kv1.3 and Kv1.5 Expression Correlates with Leiomyosarcoma Aggressiveness","volume":"4","author":"Bielanska","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.0213094","article-title":"Emerging Role for the Voltage-Dependent K+ Channel Kv1.5 in B-Lymphocyte Physiology: Expression Associated with Human Lymphoma Malignancy","volume":"94","author":"Bielanska","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4161\/cbt.4.12.2175","article-title":"Expression of Delayed Rectifier Potassium Channels and Their Possible Roles in Proliferation of Human Gastric Cancer Cells","volume":"4","author":"Lan","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"26914","DOI":"10.3390\/ijms161126002","article-title":"Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells","volume":"16","author":"Wu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_80","first-page":"153","article-title":"Selective Expression of HERG and Kv2 Channels Influences Proliferation of Uterine Cancer Cells","volume":"25","author":"Suzuki","year":"2004","journal-title":"Int. J. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Song, M.S., Park, S.M., Park, J.S., Byun, J.H., Jin, H.J., Seo, S.H., Ryu, P.D., and Lee, S.Y. (2018). Kv3.1 and Kv3.4, Are Involved in Cancer Cell Migration and Invasion. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041061"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/path.2722","article-title":"Expression and Clinical Significance of the Kv3.4 Potassium Channel Subunit in the Development and Progression of Head and Neck Squamous Cell Carcinomas","volume":"221","author":"Rodrigo","year":"2010","journal-title":"J. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbrc.2009.04.108","article-title":"Silencing of Kv4.1 Potassium Channels Inhibits Cell Proliferation of Tumorigenic Human Mammary Epithelial Cells","volume":"384","author":"Jang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00424-013-1341-x","article-title":"Up-Regulation of Kv7.1 Channels in Thromboxane A2-Induced Colonic Cancer Cell Proliferation","volume":"466","author":"Shimizu","year":"2014","journal-title":"Pflug. Arch."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1248\/bpb.33.1754","article-title":"Involvement of Kv4.1 K+ Channels in Gastric Cancer Cell Proliferation","volume":"33","author":"Kim","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12032-007-0015-y","article-title":"Aberrant Expression of Eag1 Potassium Channels in Gastric Cancer Patients and Cell Lines","volume":"24","author":"Ding","year":"2007","journal-title":"Med. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2478\/v10019-012-0043-x","article-title":"P38 MAPK Regulates the Expression of Ether \u00e0 Go-Go Potassium Channel in Human Osteosarcoma Cells","volume":"47","author":"Wu","year":"2013","journal-title":"Radiol. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.3390\/ijms15045570","article-title":"Silencing of Ether \u00e0 Go-Go 1 by ShRNA Inhibits Osteosarcoma Growth and Cell Cycle Progression","volume":"15","author":"Wu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12943-016-0529-z","article-title":"KCa1.1, a Calcium-Activated Potassium Channel Subunit Alpha 1, Is Targeted by MiR-17-5p and Modulates Cell Migration in Malignant Pleural Mesothelioma","volume":"15","author":"Cheng","year":"2016","journal-title":"Mol. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1111\/cas.15046","article-title":"Ca2+-Activated K+ Channel KCa 1.1 as a Therapeutic Target to Overcome Chemoresistance in Three-Dimensional Sarcoma Spheroid Models","volume":"112","author":"Ohya","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"36168","DOI":"10.18632\/oncotarget.8786","article-title":"SK3\/TRPC1\/Orai1 Complex Regulates SOCE-Dependent Colon Cancer Cell Migration: A Novel Opportunity to Modulate Anti-EGFR MAb Action by the Alkyl-Lipid Ohmline","volume":"7","author":"Harnois","year":"2016","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1158\/1535-7163.MCT-06-0194","article-title":"Identification of SK3 Channel as a New Mediator of Breast Cancer Cell Migration","volume":"5","author":"Potier","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An Online Survival Analysis Tool to Rapidly Assess the Effect of 22,277 Genes on Breast Cancer Prognosis Using Microarray Data of 1809 Patients","volume":"123","author":"Lanczky","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ijc.29490","article-title":"Epigenetic Dysregulation of KCa 3.1 Channels Induces Poor Prognosis in Lung Cancer","volume":"137","author":"Bulk","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Rabjerg, M., Oliv\u00e1n-Viguera, A., Hansen, L.K., Jensen, L., Sevelsted-M\u00f8ller, L., Walter, S., Jensen, B.L., Marcussen, N., and K\u00f6hler, R. (2015). High Expression of KCa3.1 in Patients with Clear Cell Renal Carcinoma Predicts High Metastatic Risk and Poor Survival. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122992"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1038\/sj.onc.1210308","article-title":"Blockage of Intermediate-Conductance-Ca2+-Activated K+ Channels Inhibits Progression of Human Endometrial Cancer","volume":"26","author":"Wang","year":"2007","journal-title":"Oncogene"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.65.3.630","article-title":"Blockage of Intermediate-Conductance Ca2+-Activated K+ Channels Inhibit Human Pancreatic Cancer Cell Growth in Vitro","volume":"65","author":"Dreker","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1158\/1535-7163.MCT-10-0511","article-title":"Knockdown of Inwardly Rectifying Potassium Channel Kir2.2 Suppresses Tumorigenesis by Inducing Reactive Oxygen Species-Mediated Cellular Senescence","volume":"9","author":"Lee","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1634\/theoncologist.2009-0185","article-title":"Parathyroid Carcinoma: Current Understanding and New Insights into Gene Expression and Intraoperative Parathyroid Hormone Kinetics","volume":"15","author":"Adam","year":"2010","journal-title":"Oncologist"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.3892\/or.2016.5064","article-title":"Elucidation of the Molecular Mechanisms of Anaplastic Thyroid Carcinoma by Integrated MiRNA and MRNA Analysis","volume":"36","author":"Liu","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2017.10.072","article-title":"Integrated Expression Profiling of Potassium Channels Identifys KCNN4 as a Prognostic Biomarker of Pancreatic Cancer","volume":"494","author":"Jiang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1158\/0008-5472.CAN-07-5163","article-title":"TREK-1 Is a Novel Molecular Target in Prostate Cancer","volume":"68","author":"Voloshyna","year":"2008","journal-title":"Cancer Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1600-0463.2004.apm1120905.x","article-title":"Altered Expression of KCNK9 in Colorectal Cancers","volume":"112","author":"Kim","year":"2004","journal-title":"Apmis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1535-6108(03)00054-0","article-title":"Genomic Amplification and Oncogenic Properties of the KCNK9 Potassium Channel Gene","volume":"3","author":"Mu","year":"2003","journal-title":"Cancer Cell"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Serrano-Novillo, C., Capera, J., Colomer-Molera, M., Condom, E., Ferreres, J.C., and Felipe, A. (2019). Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation. Cancers, 11.","DOI":"10.3390\/cancers11030287"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1101\/gad.193789.112","article-title":"Voltage-Gated Potassium Channel EAG2 Controls Mitotic Entry and Tumor Growth in Medulloblastoma via Regulating Cell Volume Dynamics","volume":"26","author":"Huang","year":"2012","journal-title":"Genes Dev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1073\/pnas.0708044105","article-title":"The Alpha9beta1 Integrin Enhances Cell Migration by Polyamine-Mediated Modulation of an Inward-Rectifier Potassium Channel","volume":"105","author":"deHart","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.bjc.6602775","article-title":"HERG1 Channels Are Overexpressed in Glioblastoma Multiforme and Modulate VEGF Secretion in Glioblastoma Cell Lines","volume":"93","author":"Masi","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1038\/srep03308","article-title":"HERG1 Channels Modulate Integrin Signaling to Trigger Angiogenesis and Tumor Progression in Colorectal Cancer","volume":"3","author":"Crociani","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/jpet.114.222000","article-title":"ATP-Sensitive Potassium Channel Activation Induces Angiogenesis In Vitro and In Vivo","volume":"354","author":"Umaru","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"15017","DOI":"10.1038\/nrdp.2015.17","article-title":"Glioma","volume":"1","author":"Weller","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3322\/caac.21693","article-title":"Brain and Other Central Nervous System Tumor Statistics, 2021","volume":"71","author":"Miller","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.21873\/anticanres.13251","article-title":"Healthcare Costs for High-Grade Glioma","volume":"39","author":"Liu","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"iii93","DOI":"10.1093\/annonc\/mdu050","article-title":"High-Grade Glioma: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up","volume":"25","author":"Stupp","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/cmi.2017.159","article-title":"Cellular Origin of Glioblastoma and Its Implication in Precision Therapy","volume":"15","author":"Yao","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2012.12.024","article-title":"Understanding High Grade Glioma: Molecular Mechanism, Therapy and Comprehensive Management","volume":"331","author":"Wang","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2014.10.FOCUS12367","article-title":"Survival and Low-Grade Glioma: The Emergence of Genetic Information","volume":"38","author":"Claus","year":"2015","journal-title":"Neurosurg. Focus"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO Classification of Tumours of the Central Nervous System","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1634\/theoncologist.2013-0345","article-title":"Low-Grade Gliomas","volume":"19","author":"Forst","year":"2014","journal-title":"Oncologist"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/0883073815600866","article-title":"Medulloblastoma","volume":"31","author":"Millard","year":"2016","journal-title":"J. Child Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/pr.117.014944","article-title":"Current Challenges and Opportunities in Treating Glioblastoma","volume":"70","author":"Shergalis","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11864-016-0418-0","article-title":"Targeted Therapeutics in Patients with High-Grade Gliomas: Past, Present, and Future","volume":"17","author":"Chen","year":"2016","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41388-017-0045-7","article-title":"Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma: Signaling Pathways and Targeted Therapies","volume":"37","author":"An","year":"2018","journal-title":"Oncogene"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2217\/imt.14.21","article-title":"Rindopepimut: A Promising Immunotherapeutic for the Treatment of Glioblastoma Multiforme","volume":"6","author":"Swartz","year":"2014","journal-title":"Immunotherapy"},{"key":"ref_126","unstructured":"Inman, S. (2022, June 11). Rindopepimut Misses OS Endpoint in Phase III Glioblastoma Trial. Available online: https:\/\/www.onclive.com\/view\/rindopepimut-misses-os-endpoint-in-phase-iii-glioblastoma-trial."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1200\/JCO.2012.47.2464","article-title":"Phase III Randomized Trial Comparing the Efficacy of Cediranib as Monotherapy, and in Combination with Lomustine, versus Lomustine Alone in Patients with Recurrent Glioblastoma","volume":"31","author":"Batchelor","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1308573","article-title":"A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma","volume":"370","author":"Gilbert","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa1308345","article-title":"Bevacizumab plus Radiotherapy-Temozolomide for Newly Diagnosed Glioblastoma","volume":"370","author":"Chinot","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jphysparis.2004.01.004","article-title":"Brain Plasticity and Ion Channels","volume":"97","author":"Debanne","year":"2003","journal-title":"J. Physiol. Paris"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"238635","DOI":"10.1155\/2013\/238635","article-title":"Stem Cells and Ion Channels","volume":"2013","author":"Liebau","year":"2013","journal-title":"Stem Cells Int."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"LBA2002","DOI":"10.1200\/JCO.2022.40.17_suppl.LBA2002","article-title":"Primary Analysis of a Phase II Trial of Dabrafenib plus Trametinib (Dab + Tram) in BRAF V600\u2013Mutant Pediatric Low-Grade Glioma (PLGG)","volume":"40","author":"Bouffet","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ccell.2015.02.001","article-title":"Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma","volume":"27","author":"Sharpe","year":"2015","journal-title":"Cancer Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"69295","DOI":"10.18632\/oncotarget.20619","article-title":"Irreversible Growth Plate Fusions in Children with Medulloblastoma Treated with a Targeted Hedgehog Pathway Inhibitor","volume":"8","author":"Robinson","year":"2017","journal-title":"Oncotarget"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1093\/neuonc\/noab087","article-title":"MEVITEM-a Phase I\/II Trial of Vismodegib + Temozolomide vs. Temozolomide in Patients with Recurrent\/Refractory Medulloblastoma with Sonic Hedgehog Pathway Activation","volume":"23","author":"Frappaz","year":"2021","journal-title":"Neuro Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/1566524015666150114115427","article-title":"Targeting the PI3K\/AKT\/MTOR Signaling Pathway in Medulloblastoma","volume":"15","author":"Dimitrova","year":"2015","journal-title":"Curr Mol Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"53","DOI":"10.21873\/anticanres.13925","article-title":"Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-Kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines","volume":"40","author":"Holzhauser","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3892\/ijo.2021.5167","article-title":"Effects of PI3K and FGFR Inhibitors Alone and in Combination, and with\/without Cytostatics in Childhood Neuroblastoma Cell Lines","volume":"58","author":"Holzhauser","year":"2021","journal-title":"Int. J. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Ghasemi, D.R., Fleischhack, G., Milde, T., and Pajtler, K.W. (2022). The Current Landscape of Targeted Clinical Trials in Non-WNT\/Non-SHH Medulloblastoma. Cancers, 14.","DOI":"10.3390\/cancers14030679"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2012.08.024","article-title":"Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma","volume":"22","author":"Sturm","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1038\/onc.2014.448","article-title":"EGFRvIII-Mediated Transactivation of Receptor Tyrosine Kinases in Glioma: Mechanism and Therapeutic Implications","volume":"34","author":"Greenall","year":"2015","journal-title":"Oncogene"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1593\/neo.09230","article-title":"The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases","volume":"11","author":"Pillay","year":"2009","journal-title":"Neoplasia"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1615\/CritRevOncog.2014011777","article-title":"Glioblastoma Heterogeneity and Cancer Cell Plasticity","volume":"19","year":"2014","journal-title":"Crit. Rev. Oncog."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI89587","article-title":"Overcoming Therapeutic Resistance in Glioblastoma: The Way Forward","volume":"127","author":"Osuka","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/stem.1605","article-title":"Glioma-Associated Stem Cells: A Novel Class of Tumor-Supporting Cells Able to Predict Prognosis of Human Low-Grade Gliomas","volume":"32","author":"Bourkoula","year":"2014","journal-title":"Stem Cells"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10014-013-0141-5","article-title":"Characteristics of Glioma Stem Cells","volume":"30","author":"Sampetrean","year":"2013","journal-title":"Brain Tumor Pathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer Stem Cells in Glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes Dev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00109-009-0440-9","article-title":"Tumor Initiating Cells in Malignant Gliomas: Biology and Implications for Therapy","volume":"87","author":"Hadjipanayis","year":"2009","journal-title":"J. Mol. Med."},{"key":"ref_150","first-page":"17","article-title":"Mechanisms of Temozolomide Resistance in Glioblastoma\u2014A Comprehensive Review","volume":"4","author":"Singh","year":"2021","journal-title":"Cancer Drug Resist."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1101\/gr.180612.114","article-title":"Whole-Genome and Multisector Exome Sequencing of Primary and Post-Treatment Glioblastoma Reveals Patterns of Tumor Evolution","volume":"25","author":"Kim","year":"2015","journal-title":"Genome Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/stem.2703","article-title":"Genetic Evolution of Glioblastoma Stem-Like Cells from Primary to Recurrent Tumor","volume":"35","author":"Orzan","year":"2017","journal-title":"Stem Cells"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Dube, C., Gibert, M., Cruickshanks, N., Wang, B., Coughlan, M., Yang, Y., Setiady, I., Deveau, C., and Saoud, K. (2018). The P53 Pathway in Glioblastoma. Cancers, 10.","DOI":"10.3390\/cancers10090297"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2217\/cns.12.46","article-title":"Exploitation of Adaptive Evolution in Glioma Treatment","volume":"2","author":"Cordner","year":"2013","journal-title":"CNS Oncol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Ruggieri, P., Mangino, G., Fioretti, B., Catacuzzeno, L., Puca, R., Ponti, D., Miscusi, M., Franciolini, F., Ragona, G., and Calogero, A. (2012). The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047825"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1002\/jcp.25592","article-title":"Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration","volume":"232","author":"Rosa","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1002\/jcp.26120","article-title":"Mesenchymal Stem Cell Differentiation: Control by Calcium-Activated Potassium Channels","volume":"233","author":"Pchelintseva","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1038\/s41467-019-13657-6","article-title":"ScRNA-Seq in Medulloblastoma Shows Cellular Heterogeneity and Lineage Expansion Support Resistance to SHH Inhibitor Therapy","volume":"10","author":"Ocasio","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccr.2014.05.005","article-title":"Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma","volume":"26","author":"Vanner","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2217\/cns-2016-0001","article-title":"Sox2: Regulation of Expression and Contribution to Brain Tumors","volume":"5","author":"Mansouri","year":"2016","journal-title":"CNS Oncol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Metz, E.P., Wuebben, E.L., Wilder, P.J., Cox, J.L., Datta, K., Coulter, D., and Rizzino, A. (2020). Tumor Quiescence: Elevating SOX2 in Diverse Tumor Cell Types Downregulates a Broad Spectrum of the Cell Cycle Machinery and Inhibits Tumor Growth. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07370-7"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"eabj9138","DOI":"10.1126\/sciadv.abj9138","article-title":"Noncanonical Activation of GLI Signaling in SOX2+ Cells Drives Medulloblastoma Relapse","volume":"8","author":"Oles","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1152\/jn.2001.85.2.790","article-title":"BK Channels in Human Glioma Cells","volume":"85","author":"Ransom","year":"2001","journal-title":"J. Neurophysiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1423-0127-16-90","article-title":"Menthol Increases Human Glioblastoma Intracellular Ca2+, BK Channel Activity and Cell Migration","volume":"16","author":"Wondergem","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Abdullaev, I.F., Rudkouskaya, A., Mongin, A.A., and Kuo, Y.-H. (2010). Calcium-Activated Potassium Channels BK and IK1 Are Functionally Expressed in Human Gliomas but Do Not Regulate Cell Proliferation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012304"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jnr.20240","article-title":"Role for Calcium-Activated Potassium Channels (BK) in Growth Control of Human Malignant Glioma Cells","volume":"78","author":"Weaver","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00424-003-1012-4","article-title":"BK Channel Openers Inhibit Migration of Human Glioma Cells","volume":"446","author":"Kraft","year":"2003","journal-title":"Pflug. Arch."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1523\/JNEUROSCI.13-08-03333.1993","article-title":"Inward-Rectifying Potassium Channels in Retinal Glial (M\u00fcller) Cells","volume":"13","author":"Newman","year":"1993","journal-title":"J. Neurosci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/glia.10346","article-title":"Mislocalization of Kir Channels in Malignant Glia","volume":"46","author":"Olsen","year":"2004","journal-title":"Glia"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/jn.1988.59.1.259","article-title":"Potassium-Induced Spontaneous Electrographic Seizures in the Rat Hippocampal Slice","volume":"59","author":"Traynelis","year":"1988","journal-title":"J. Neurophysiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"595664","DOI":"10.3389\/fnins.2020.595664","article-title":"Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism?","volume":"14","author":"Brandalise","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1038\/s41598-018-25940-5","article-title":"Kv1.3 Activity Perturbs the Homeostatic Properties of Astrocytes in Glioma","volume":"8","author":"Grimaldi","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(03)00562-7","article-title":"Expression of Voltage-Gated Potassium Channels Kv1.3 and Kv1.5 in Human Gliomas","volume":"346","author":"Preussat","year":"2003","journal-title":"Neurosci. Lett."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez, R., St\u00fchmer, W., Martin, S., Schell, J., Reichmann, A., Rohde, V., and Pardo, L. (2015). Analysis of the Expression of Kv10.1 Potassium Channel in Patients with Brain Metastases and Glioblastoma Multiforme: Impact on Survival. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1848-y"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.3892\/ol.2016.4992","article-title":"Suppression of the Eag1 Potassium Channel Sensitizes Glioblastoma Cells to Injury Caused by Temozolomide","volume":"12","author":"Sales","year":"2016","journal-title":"Oncol Lett."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/bjc.2015.28","article-title":"HERG1 Channels Drive Tumour Malignancy and May Serve as Prognostic Factor in Pancreatic Ductal Adenocarcinoma","volume":"112","author":"Lastraioli","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Staudacher, I., Jehle, J., Staudacher, K., Pledl, H.-W., Lemke, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2014). HERG K+ Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088164"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neulet.2004.07.001","article-title":"Expression of Ether \u00e0 Go-Go Potassium Channels in Human Gliomas","volume":"368","author":"Patt","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"74895","DOI":"10.18632\/oncotarget.12462","article-title":"A Three Ion Channel Genes-Based Signature Predicts Prognosis of Primary Glioblastoma Patients and Reveals a Chemotherapy Sensitive Subtype","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","article-title":"Electrical and Synaptic Integration of Glioma into Neural Circuits","volume":"573","author":"Venkatesh","year":"2019","journal-title":"Nature"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2015.04.012","article-title":"Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion","volume":"161","author":"Venkatesh","year":"2015","journal-title":"Cell"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Augustus, M., Pineau, D., Aimond, F., Azar, S., Lecca, D., Scamps, F., Muxel, S., Darlix, A., Ritchie, W., and Goz\u00e9, C. (2021). Identification of CRYAB+ KCNN3+ SOX9+ Astrocyte-Like and EGFR+ PDGFRA+ OLIG1+ Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis. Cancers, 13.","DOI":"10.3390\/cancers13092107"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/02688697.2011.583365","article-title":"Differential Expression of a Novel Voltage Gated Potassium Channel--Kv 1.5 in Astrocytomas and Its Impact on Prognosis in Glioblastoma","volume":"26","author":"Arvind","year":"2012","journal-title":"Br. J. Neurosurg."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fphys.2013.00283","article-title":"The Voltage-Dependent K+ Channels Kv1.3 and Kv1.5 in Human Cancer","volume":"4","author":"Comes","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1523\/JNEUROSCI.22-05-01840.2002","article-title":"Cloning and Characterization of Glioma BK, a Novel BK Channel Isoform Highly Expressed in Human Glioma Cells","volume":"22","author":"Liu","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nn.4088","article-title":"EAG2 Potassium Channel with Evolutionarily Conserved Function as a Brain Tumor Target","volume":"18","author":"Huang","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"e20190971","DOI":"10.1084\/jem.20190971","article-title":"Chloride Intracellular Channel 1 Cooperates with Potassium Channel EAG2 to Promote Medulloblastoma Growth","volume":"217","author":"Francisco","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"ii109","DOI":"10.1093\/neuonc\/noz036.187","article-title":"MEDU-28. Eliminating the Root of Medulloblastoma by Targeting a Voltage-Gated Potassium Channel","volume":"21","author":"Fan","year":"2019","journal-title":"Neuro Oncol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/cas.12925","article-title":"Medulloblastoma Stem Cells: Promising Targets in Medulloblastoma Therapy","volume":"107","author":"Huang","year":"2016","journal-title":"Cancer Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A Comprehensive Map of Molecular Drug Targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: A Major Update to the DrugBank Database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00036.2011","article-title":"HERG K+ Channels: Structure, Function, and Clinical Significance","volume":"92","author":"Vandenberg","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2165\/00002018-200225120-00003","article-title":"A Benefit-Risk Assessment of Class III Antiarrhythmic Agents","volume":"25","author":"Brendorp","year":"2002","journal-title":"Drug Saf."},{"key":"ref_194","first-page":"936","article-title":"The Role of Nateglinide and Repaglinide, Derivatives of Meglitinide, in the Treatment of Type 2 Diabetes Mellitus","volume":"9","author":"Prioletta","year":"2013","journal-title":"Arch. Med. 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Gn 1 gnathopod 1; Gn 1\u2019, Gn 1 \u2018\u2019, Gn 1 \u2018\u2019\u2019 palm and dactylus enlarged; gnathopod 1 dactylus and propodus enlarged; Gn 2 gnathopod 2.","reference-count":0,"publisher":"Pensoft Publishers","content-domain":{"domain":[],"crossmark-restriction":false},"DOI":"10.3897\/zse.91.5715.figure2","type":"component","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T04:35:13Z","timestamp":1495686913000},"source":"Crossref","is-referenced-by-count":0,"title":["Figure 2 from: Krapp-Schickel T, Vader W (2015) Stenothoids living with or on other animals (Crustacea, Amphipoda). Zoosystematics and Evolution 91(2): 215-246. https:\/\/doi.org\/10.3897\/zse.91.5715"],"prefix":"10.3897","member":"2258","deposited":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T10:38:26Z","timestamp":1495708706000},"score":16.421265,"resource":{"primary":{"URL":"http:\/\/zse.pensoft.net\/article\/5715\/element\/2\/12\/"}},"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3897\/zse.91.5715.figure2","relation":{"is-component-of":[{"id-type":"doi","id":"10.3897\/zse.91.5715","asserted-by":"object"}]}},{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:37:39Z","timestamp":1769506659037,"version":"3.49.0"},"reference-count":0,"publisher":"Asociatia de Geografie, Turism si Sport","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GTG"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"The aim of this project was to analyze the meaning of the creative economy in the Minangkabau community in the tourist destination area of West Sumatra. This research uses a descriptive qualitative approach. This research was from the province of West Sumatra. Data collection by observation, Focus Group Discussion (FGD), and in-depth interviews. The results showed that the creative economy had created economic added value, increased tourism, and strengthened local culture. Economic actors' actions in tourist destination areas prioritize rational economic actions and do not consider economic motives. The creative economy is not influenced by local habits or culture in taking action so that economic actors prioritize earning profits. The meaning of the Minangkabau community's creative economy in the tourist destination area is action prioritizing profit, action-oriented towards prospects, the action being accessible to all levels, action prioritizing opportunities, and actions have attractiveness and habits. It is shown that these creative economic actions tend to ignore the socio-cultural elements of local products. Cultural values drive the development of the creative industry in West Sumatra. The attractiveness and habits of local tourists and tourists from mancanagara (foreign tourists) become capital and action in the creative economy.<\/jats:p>","DOI":"10.30892\/gtg.334spl16-607","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T08:16:41Z","timestamp":1609402601000},"page":"1551-1556","source":"Crossref","is-referenced-by-count":4,"title":["THE MEANING OF CREATIVE ECONOMY IN THE MINANGKABU COMMUNITY IN THE WEST SUMATRA TOURISM DESTINATION AREA, INDONESIA"],"prefix":"10.30892","volume":"33","author":[{"name":"Sociology Education Study Program, STKIP PGRI West Sumatra, Jl. Gn. Pangilun, Gn. Pangilun, Kec. 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