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Thus, action of some sedatives and local analgesics in various regional anaesthesia in calves and their evaluation in respect of doses are of great significance. The approximation of dose rate of available sedatives in calves may be helpful for the practitioners. \u00a0 Objectives: To determine the general effect of clinically useful dose of the sedatives produced by xylazine and lignocaine with adrenaline and bupivacaine for umbilical surgery in calves. \u00a0 Materials and Methods: The experiment was performed on 20 affected with umbilical hernia, 6 were indigenous (local) and 14 were crossbred. They were divided into 4 groups and each group included 5 calves. Groupp A was sedated with xylazine hydrochloride and 2% lignocaine hydrochloride; Group B with xylazine hydrochloride followed by 0.5% bupivcaine hydrochloride; Group C with diazepam followed by 2% lignocaine hydrochloride; and Group D diazepam followed by 0.5% bupivacaine. Respiratory rate, heart rate and rectal temperature were recorded before administration of sedatives and at 15, 30, 45, 60 minutes after sedation and local analgesia. \u00a0 Results: Heart rate and respiration rate significantly (p&lt;0.01) decreased during sedation with xylazine hydrochloride plus 2% lignocaine hydrochloride or 0.5% bupivacaine hydrochloride. A significantly decreased (p&lt;0.01) heart rate and respiration rate also found during sedation with diazepam plus 2% lignocaine hydrochloride or 0.5% bupivacaine hydrochloride. Duration of analgesia was longer with 0.5 % bupivacaine hydrochloride (55.88 \u00b1 1.58 min in Group B and 48\u00b111.25 min in Group D) compared to 2% lignocaine hydrochloride (39.60 \u00b1 5.77 min in Group A and 43.6 \u00b1 5.81 min in Group C). 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Dyn."},{"volume-title":"Kinematic and Dynamic Simulation of Multibody Systems: The Real-Time Challenge","year":"1994","key":"2021061612495303200_bib42"}],"container-title":["Journal of Computational and Nonlinear Dynamics"],"language":"en","link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/computationalnonlinear\/article-pdf\/16\/8\/081002\/6712198\/cnd_016_08_081002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/asmedigitalcollection.asme.org\/computationalnonlinear\/article-pdf\/16\/8\/081002\/6712198\/cnd_016_08_081002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T12:51:50Z","timestamp":1623847910000},"score":15.6924925,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/computationalnonlinear\/article\/16\/8\/081002\/1109301\/Predictive-Trajectory-Tracking-Algorithm-of"}},"issued":{"date-parts":[[2021,6,16]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1115\/1.4051168","ISSN":["1555-1415","1555-1423"],"issn-type":[{"type":"print","value":"1555-1415"},{"type":"electronic","value":"1555-1423"}],"published":{"date-parts":[[2021,6,16]]},"article-number":"081002"},{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:27:21Z","timestamp":1761294441798,"version":"3.41.2"},"reference-count":44,"publisher":"The Royal Society","issue":"188","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Hungarian National Research, Development and Innovation Office","award":["NKFI-K138621"],"award-info":[{"award-number":["NKFI-K138621"]}]},{"DOI":"10.13039\/501100015498","name":"Ministry for Innovation and Technology","doi-asserted-by":"crossref","award":["TKP2020 IES: BME-IE-BIO; TKP2020 NC: BME-NC"],"award-info":[{"award-number":["TKP2020 IES: BME-IE-BIO; TKP2020 NC: BME-NC"]}],"id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n            Human reaction delay significantly limits manual control of unstable systems. It is more difficult to balance a short stick on a fingertip than a long one, because a shorter stick falls faster and therefore requires faster reactions. In this study, a virtual stick balancing environment was developed where the reaction delay can be artificially modulated and the law of motion can be changed between second-order (Newtonian) and first-order (Aristotelian) dynamics. Twenty-four subjects were separated into two groups and asked to perform virtual stick balancing programmed according to either Newtonian or Aristotelian dynamics. The shortest stick length (critical length,\n            <jats:italic>L<\/jats:italic>\n            <jats:sub>\n              <jats:italic>c<\/jats:italic>\n            <\/jats:sub>\n            ) was determined for different added delays in six sessions of balancing trials performed on different days. The observed relation between\n            <jats:italic>L<\/jats:italic>\n            <jats:sub>\n              <jats:italic>c<\/jats:italic>\n            <\/jats:sub>\n            and the overall reaction delay\n            <jats:italic>\u03c4<\/jats:italic>\n            reflected the feature of the underlying mathematical models: (i) for the Newtonian dynamics\n            <jats:italic>L<\/jats:italic>\n            <jats:sub>\n              <jats:italic>c<\/jats:italic>\n            <\/jats:sub>\n            is proportional to\n            <jats:italic>\u03c4<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            ; (ii) for the Aristotelian dynamics\n            <jats:italic>L<\/jats:italic>\n            <jats:sub>\n              <jats:italic>c<\/jats:italic>\n            <\/jats:sub>\n            is proportional to\n            <jats:italic>\u03c4<\/jats:italic>\n            . Deviation of the measured\n            <jats:italic>L<\/jats:italic>\n            <jats:sub>\n              <jats:italic>c<\/jats:italic>\n            <\/jats:sub>\n            (\n            <jats:italic>\u03c4<\/jats:italic>\n            ) function from the theoretical one was larger for the Newtonian dynamics for all sessions, which suggests that, at least in virtually controlled tasks, it is more difficult to adopt second-order dynamics than first-order dynamics.\n          <\/jats:p>","DOI":"10.1098\/rsif.2021.0854","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:06:42Z","timestamp":1646208402000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Virtual stick balancing: skill development in Newtonian and Aristotelian dynamics"],"prefix":"10.1098","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-730X","authenticated-orcid":true,"given":"Balazs A.","family":"Kovacs","sequence":"first","affiliation":[{"name":"Department of Applied Mechanics, Faculty of Mechanical Engineering, Budapest University of Technology and Economics and MTA-BME Lend\u00fclet Human Balancing Research Group, Budapest, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-9774","authenticated-orcid":true,"given":"Tamas","family":"Insperger","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics, Faculty of Mechanical Engineering, Budapest University of Technology and Economics and MTA-BME Lend\u00fclet Human Balancing Research Group, Budapest, Hungary"}]}],"member":"175","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trc.2018.04.005"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.5042090"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90305-4"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.06.018"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2020.0956"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2012.0077"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00222895.1985.10735340"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200405000-00002"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-84582-7"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/9781316026847"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.003"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.2.942"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00131"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.0212"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3311\/PPme.13807"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2008.0278"},{"key":"e_1_3_6_18_2","unstructured":"Allen RW Hogue JR Parseghian Z. 1986 Manual control of unstable systems. In Proc. 21st Annu. Conf. on Manual Control p. 32.1. San Jos CA: NASA."},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0636"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2014.2352173"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.191006"},{"key":"e_1_3_6_22_2","doi-asserted-by":"crossref","unstructured":"Cesonis J Franklin S Franklin DW. 2018 A simulated inverted pendulum to investigate human sensorimotor control. In Proc. 2018 40th Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society (EMBC) . IEEE.","DOI":"10.1109\/EMBC.2018.8513434"},{"key":"e_1_3_6_23_2","doi-asserted-by":"crossref","unstructured":"Franklin S Cesonis J Leib R Franklin DW. 2019 Feedback delay changes the control of an inverted pendulum. In Proc. 2019 41st Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society (EMBC) . 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In Handbook of perception and action (eds H Heuer, SW Keele), pp. 71-120. Amsterdam, The Netherlands: Academic Press."},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/89477"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00215.2005"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/2\/3\/S04"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1587\/nolta.4.129"}],"container-title":["Journal of The Royal Society Interface"],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2021.0854","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2021.0854","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2021.0854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:07:23Z","timestamp":1646208443000},"score":15.6906395,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2021.0854"}},"issued":{"date-parts":[[2022,3]]},"references-count":44,"journal-issue":{"issue":"188","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1098\/rsif.2021.0854"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2021.0854","ISSN":["1742-5662"],"issn-type":[{"type":"electronic","value":"1742-5662"}],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2021-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20210854"},{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:16:35Z","timestamp":1770912995975,"version":"3.50.1"},"reference-count":0,"publisher":"Academy of Science of South Africa","issue":"2 April","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WSA"],"abstract":"<jats:p>Dye usage for industrial applications has been on the increase and these activities generate large amounts of dye-constituted wastewater that should be treated before environmental discharge or reuse. Various studies have shown the application of natural organic polymer (NOP) coagulants in dye removal from industrial wastewater. In this research, the coagulation performances of Vigna unguiculata (VU) and Telfairia occidentalis (TO) for colour removal from crystal Ponceau 6R dye synthetic wastewater was studied. The proximate compositions, structure, and surface morphologies of the coagulants were investigated using standard methods, i.e. Fourier-Transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). Colour removal was evaluated through the time-dependent decrease in particle concentration and thus growth of flocs. Effects of the process parameters, including pH, coagulant dosage, dye concentration (DC), settling time, and temperature were preliminarily tested and the best range experimentally determined. The optimal operating conditions established were pH 2, 800 mg\u2219L\u22121 coagulant dosage, 100 mg\u2219L\u22121 dye concentration, 300 min, and 303 K. The order of greatest removal was VUC &gt; TOC with optimum efficiency of 93.5% and 90.7%, respectively. The values of K and \u03b1 obtained for VUC and TOC were 8.09 x 10\u22124 L\u2219mg\u22121\u2219min\u22121, 1.7 and 9.89 x 10-4 L\u2219mg\u22121\u2219min\u22121, 1.6, respectively. Coagulation time, Tag, calculated and deduced from the particle distribution plot, showed a rapid coagulation process. Coagulation-adsorption kinetics indicated agreement with the pseudo-second-order model deducing that chemisorption is the rate-controlling step. It further indicates that particle adsorption on the polymer surfaces occurred mostly as a mono-molecular layer and according to the chemisorption mechanism. Cross-validation showed good prediction of the experimental data. The selected coagulants have the potential for application as efficient coagulants while also showing significant adsorption characteristics. The application of kinetics and modelling in separation processes involving particle transfer is especially required in wastewater treatment.<\/jats:p>","DOI":"10.17159\/wsa.2020.v46.i2.8246","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T10:10:11Z","timestamp":1632910211000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of bio-coagulants for colour removal from dye synthetic wastewater: characterization, adsorption kinetics, and modelling approach"],"prefix":"10.17159","volume":"46","author":[{"family":"IA Obiora-Okafo","sequence":"first","affiliation":[]},{"family":"OD Onukwuli","sequence":"additional","affiliation":[]},{"family":"NC Eli-Chukwu","sequence":"additional","affiliation":[]}],"member":"6689","published-online":{"date-parts":[[2020,4,29]]},"container-title":["Water SA"],"link":[{"URL":"https:\/\/watersa.net\/article\/download\/8246\/10016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/watersa.net\/article\/download\/8246\/10016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:23:32Z","timestamp":1770909812000},"score":15.614866,"resource":{"primary":{"URL":"https:\/\/watersa.net\/article\/view\/8246"}},"issued":{"date-parts":[[2020,4,29]]},"references-count":0,"aliases":["10.17159\/\/wsa\/2020.v46.i2.8246","10.17159\/wsa\/2020.v46.i2.8246"],"journal-issue":{"issue":"2 April","published-online":{"date-parts":[[2020,4,30]]}},"URL":"https:\/\/doi.org\/10.17159\/wsa.2020.v46.i2.8246","ISSN":["1816-7950"],"issn-type":[{"value":"1816-7950","type":"electronic"}],"published":{"date-parts":[[2020,4,29]]}},{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:38:06Z","timestamp":1770287886352,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Immortal mast cell lines, such as RBL\u20102H3 and HMC\u20101 cells, are commonly utilized to investigate the function of mast cells. However, they are tumor cells carrying a gain\u2010of\u2010function mutation of <jats:italic>Kit<\/jats:italic>. We established an immortal mast cell line without <jats:italic>Kit<\/jats:italic> mutation, NCL\u20102, derived from NC mouse bone marrow. NCL\u20102 cells could be maintained without additional growth factors and thus could respond to exogenous growth signals. Moreover, NCL\u20102 cells expressed Fc\u03b5RI and KIT, and release histamine and LTB<jats:sub>4<\/jats:sub> in response to antigen stimulation. 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All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"134117"},{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:31:18Z","timestamp":1766050278299,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BBSRC DTP","award":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"],"award-info":[{"award-number":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"]}]},{"name":"Nottinghamshire Leukaemia Appeal","award":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"],"award-info":[{"award-number":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"]}]},{"name":"University of Nottingham (Anne McLaren Fellowship)","award":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"],"award-info":[{"award-number":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"]}]},{"name":"EPSRC grants","award":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"],"award-info":[{"award-number":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"]}]},{"name":"NC3Rs grants","award":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"],"award-info":[{"award-number":["EP\/R035067\/1","EP\/R035563\/1,785","EP\/R035156\/1","NC\/N001583\/1","NC\/T001259\/1","NC\/T001267\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to drug resistance. Candidate drug discovery in AML requires advanced synthetic platforms to improve our understanding of the impact of mechanical cues on drug sensitivity in AML. By use of a synthetic, self-assembling peptide hydrogel (SAPH) of modifiable stiffness and composition, a 3D model of the bone marrow niche to screen repurposed FDA-approved drugs has been developed and utilized. AML cell proliferation was dependent on SAPH stiffness, which was optimized to facilitate colony growth. Three candidate FDA-approved drugs were initially screened against the THP-1 cell line and mAF9 primary cells in liquid culture, and EC50 values were used to inform drug sensitivity assays in the peptide hydrogel models. Salinomycin demonstrated efficacy in both an \u2018early-stage\u2019 model in which treatment was added shortly after initiation of AML cell encapsulation, and an \u2018established\u2019 model in which time-encapsulated cells had started to form colonies. Sensitivity to Vidofludimus treatment was not observed in the hydrogel models, and Atorvastatin demonstrated increased sensitivity in the \u2018established\u2019 compared to the \u2018early-stage\u2019 model. AML patient samples were equally sensitive to Salinomycin in the 3D hydrogels and partially sensitive to Atorvastatin. Together, this confirms that AML cell sensitivity is drug- and context-specific and that advanced synthetic platforms for higher throughput are valuable tools for pre-clinical evaluation of candidate anti-AML drugs.<\/jats:p>","DOI":"10.3390\/ijms24044235","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:07:44Z","timestamp":1676945264000},"page":"4235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML"],"prefix":"10.3390","volume":"24","author":[{"given":"Jenna R.","family":"James","sequence":"first","affiliation":[{"name":"Blood Cancer and Stem Cell Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"Optics and Photonics Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-1273","authenticated-orcid":false,"given":"Johnathan","family":"Curd","sequence":"additional","affiliation":[{"name":"Stem Cell Glycobiology Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-8876","authenticated-orcid":false,"given":"Jennifer C.","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Stem Cell Glycobiology Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"},{"name":"School of Veterinary Medicine & Science, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"given":"Mays","family":"Abuhantash","sequence":"additional","affiliation":[{"name":"Blood Cancer and Stem Cell Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"given":"Martin","family":"Grundy","sequence":"additional","affiliation":[{"name":"Blood Cancer and Stem Cell Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-4045","authenticated-orcid":false,"given":"Claire H.","family":"Seedhouse","sequence":"additional","affiliation":[{"name":"Blood Cancer and Stem Cell Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-6055","authenticated-orcid":false,"given":"Kenton P.","family":"Arkill","sequence":"additional","affiliation":[{"name":"Endothelial and Vascular Imaging Laboratories, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"given":"Amanda J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Optics and Photonics Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-2809","authenticated-orcid":false,"given":"Catherine L. R.","family":"Merry","sequence":"additional","affiliation":[{"name":"Stem Cell Glycobiology Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-5321","authenticated-orcid":false,"given":"Alexander","family":"Thompson","sequence":"additional","affiliation":[{"name":"Blood Cancer and Stem Cell Group, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2017.08.001","article-title":"Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia","volume":"32","author":"Passaro","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1182\/blood-2010-05-282632","article-title":"Incidence of hematologic malignancies in Europe by morphologic subtype: Results of the HAEMACARE project","volume":"116","author":"Sant","year":"2010","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"Dohner","year":"2022","journal-title":"Blood"},{"key":"ref_4","first-page":"1","article-title":"Acute myeloid leukemia in the older adults","volume":"6","author":"Almeida","year":"2016","journal-title":"Leuk. 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